Channel: Johns Hopkins University

This collection includes bioRxiv and medRxiv papers from authors at Johns Hopkins University.

6569 Articles

Shared multicellular injury programs of acute and chronic kidney disease enable mechanistic patient stratification

Fallegger, R., Gomez-Ochoa, S. A., Boys, C., Ramirez Flores, R. O., Tanevski, J., Pashos, E., Feliers, D., Piper, M., Schaub, J. A., Zhou, Z., Mao, W., Chen, X., Sealfon, R. S. G., Menon, R., Nair, V., Eddy, S., Alakwaa, F. M., Pyle, L., Choi, Y. J., Bjornstad, P., Alpers, C. E., Bitzer, M., Bomback, A. S., Caramori, M. L., Demeke, D., Fogo, A. B., Herlitz, L. C., Kiryluk, K., Lash, J. P., Murugan, R., O'Toole, J. F., Palevsky, P. M., Parikh, C. R., Rosas, S. E., Rosenberg, A. Z., Sedor, J. R., Vazquez, M. A., Waikar, S. S., Wilson, F. P., Hodgin, J. B., Barisoni, L., Himmelfarb, J., Jain, S.

10.64898/2026.03.05.26347522 — Posted: 2026-03-06

The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney

Katti, P., Prasad, P., Masenga, S. K., Venkhatesh, P., Vue, Z., Marshall, A. G., Rodrageaz, B., Le, H., Garza-Lopez, E., Murphy, A., Jenkins, B., Kadam, A., Shao, J., Crabtree, A., Martin, P., Evans, C., Phillips, M. A., Hubert, D., Wandira, N., Ochayi, O. M., Tomar, D., Williams, C. R., Gaddy, J., Tomeau, B., Bell, L., Gillyard, T., Hamilton, M., Sharma, V., Khan, M. M., Zaganjor, E., Ajijola, O., Scudese, E., Miller-Fleming, T. W., Kinder, A., Dash, C., Quintana, A., Mobley, B. C., Berry, J., Jadiya, P., Dai, D.-F., Kirabo, A., Kovtun, O., Schafer, J. C., Schaffer, S., Pereira, R. O., McReyn

10.1101/2024.06.09.598108 — Posted: 2026-03-05

Machine Learning Ensemble Reveals Distinct Molecular Pathways of Retinal Damage in Spaceflown Mice

Casaletto, J. A., Scott, R. T., Rathod, A., Jain, A., Chandar, A., Adapala, A., Prajapati, A., Nautiyal, A., Jayaraman, A., Boddu, A., Kelam, A., Jain, A., Pham, B., Shastry, D., Narayanan, D., Kosaraju, E., Paley, E., Uribe, F. P., Shahid, I., Ye, I., Wu, J., Lin, J., Srinivas, K., Della Monica, M. P., Hitt, M., Lin, M., Volkan, M., Kharya, M., Kaul, M., Jaffer, M. A., Ali, M., Chang, N. Z., Ashri, N., Couderc, N. B., Paladugu, P., Sood, R., Hiremath, R., Pathak, R., Dogra, S., Srinivas, S., Samaddar, S., Gopinath, S., Sawant, S., Cai, S., Pala, V., Nair, V., Shi, Z., Narayanan, S., Mundackal

10.64898/2026.01.22.701181 — Posted: 2026-03-05

Deep Learning Enabled 3D Multi-Omic Analysis Reveals Molecular Signatures of Heterogeneous Response to Chemotherapy in Pancreatic Cancer

Forjaz, A., Mojdeganlou, H., Valentin, A., Wetzel, M., Lvovs, D., Deshpande, A., Shin, S. M., Piya, S., Rajapakshe, K. I., Guerrero, P. A., Pedro, B. A., Sidiropoulos, D. N., Wu, P.-H., Bernard Pagan, V., Demystifying Pancreatic Cancer Therapies TeamLab, , Wirtz, D., Fertig, E. J., Kagohara, L. T., Ho, W. J., Kiemen, A. L., Wood, L. D.

10.64898/2026.03.03.709150 — Posted: 2026-03-05

Subclonal Complete Loss of CDKN1B as a Common Genomic Alteration in Prostate Cancer: Associations with Race and Prostate Cancer Outcomes

Sfanos, K., Morton, R., Flores, J., Sosa, R., Ernst, S., Mummert, L., Hicks, J., Lotan, T. L., Lu, J., Jing, Y., Joshu, C., De Marzo, A. M.

10.64898/2026.03.03.709424 — Posted: 2026-03-05

Reactive Astrocytes Drive Extracellular Acidification to Mediate α-Synuclein Neurodegeneration

Song, J.-J., Park, H., Choi, Y., Ryu, T., Shin, J., Kim, S.-H., Park, A., Wang, J., Biswas, D., Chou, S.-C., Ha, S., Jang, Y., Shin, Y., Chen, G., Hong, I., Wemmie, J., Svenningsson, P., Troncoso, J., Xu, J., Na, C. H., Dawson, V. L., Dawson, T., Kam, T.-I.

10.64898/2026.01.06.697893 — Posted: 2026-03-04

Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15 critical for mechanotransduction

Liang, X., Pathak, R., Qiu, X., Dillard, L., Twomey, E. C., Mueller, U.

10.64898/2026.03.02.709101 — Posted: 2026-03-04

Recovering signatures of archaic introgression using ancestral recombination graphs

Zhang, Y., Biddanda, A., Johnson, S. A., O'Dushlaine, C., Moorjani, P.

10.64898/2026.03.03.709416 — Posted: 2026-03-04

Healthcare utilization and cost impact of telehealth-delivered nutrition therapy for type 2 diabetes and obesity: a retrospective claims-based study

Shanmugam, P., Adams, R. N., Athinarayanan, S., Wolfberg, A., Ballreich, J.

10.1101/2025.11.09.25339829 — Posted: 2026-03-04

Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus

Xiang, Q., Wouters, C., Chang, P., Lu, Y.-N., Liu, M., Wang, H., Heine, H., Qian, S., Yang, J., Pekosz, A., Zhang, Y., Wang, J.

10.1101/2024.12.04.624804 — Posted: 2026-03-03

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