Channel: Vanderbilt University

This collection includes bioRxiv and medRxiv papers from authors at Vanderbilt University.

2754 Articles

Genomics-Informed Drug Repurposing Strategy Identifies Novel Therapeutic Targets for Metabolic Dysfunction-Associated Steatotic Liver Disease.

Seagle, H. M., Akerele, A. P., DeCorte, J. A., Hellwege, J. N., Breeyear, J. H., Kim, J., Levin, M., Khodurksy, S., Bress, A. P., Lee, K., Meiler, J., Gill, D., Lee, J. S., Heberer, K., Miller, D. R., Reavan, P., Chang, K.-M., Lynch, J., Khankari, N. K., Shuey, M., Edwards, T. L., Vujkovic, M.

10.1101/2025.02.18.25321035 — Posted: 2025-02-21

Linking molecular pathways and islet cell dysfunction in human type 1 diabetes

dos Santos, T., Dai, X. Q., Jones, R. C., Spigelman, A. F., Mummey, H. M., Ewald, J. D., Ellis, C. E., Lyon, J. G., Smith, N., Bautista, A., Manning Fox, J. E., Neff, N. F., Detweiler, A., Tan, M., Arrojo e Drigo, R., Xia, J., Camunas-Soler, J., Gaulton, K. J., Quake, S. R., MacDonald, P. E.

10.1101/2025.02.20.639325 — Posted: 2025-02-21

Genetics of cardiovascular outcomes in individuals with chronic kidney disease: the Chronic Renal Insufficiency Cohort (CRIC) study

Wen, J., Lin, B. M., Sun, Q., Jiang, M.-Z., Linchangco, G., Li, G., Chen, R., Go, A. S., Miller-Fleming, T. W., Shuey, M. M., Cohen, D. L., Rao, P. S., Rahman, M., Cox, N. J., Lash, J. P., Guan, W., Posner, D. C., Hui, Q., Houghton, S. C., Hung, A. M., Cho, K., Wilson, P. W. F., Zhou, H., Sun, Y. V., Li, Y., Franceschini, N.

10.1101/2025.02.19.25322572 — Posted: 2025-02-21

In vitro cellular phenotypes of cortical neurons from R255X MECP2 knock-in mice are improved by either expression of wildtype MeCP2 or read-through with G418

Xu, X., Merritt, J. K., Gray, S. J., Neul, J., Pozzo-Miller, L.

10.1101/2025.02.17.638700 — Posted: 2025-02-21

Type 2 diabetes polygenic risk score demonstrates context-dependent effects and associations with type 2 diabetes-related risk factors and complications across diverse populations

Guo, B., Cai, Y., Kim, D., Smit, R. A. J., Wang, Z., Iyer, K. R., Hilliard, A. T., Haessler, J., Tao, R., Broadaway, K. A., Wang, Y., Pozdeyev, N., Staeger, F. F., Yang, C., Vanderwerff, B., Patki, A. D., Stalbow, L., Lin, M., Rafaels, N., Shortt, J., Wiley, L., Stanislawski, M., Pattee, J., Davis, L., Straub, P. S., Shuey, M. M., Cox, N. J., Lee, N. R., Jorgensen, M. E., Bjerregaard, P., Larsen, C., Hansen, T., Moltke, I., Meigs, J. B., Stram, D. O., Yin, X., Zhou, X., Chang, K.-M., Clarke, S. L., Guarischi-Sousa, R., Lankester, J., Tsao, P. S., Buyske, S., Graff, M., Raffield, L. M., Sun, Q.

10.1101/2025.02.15.25322341 — Posted: 2025-02-20

Lipid peroxidation and colorectal cancer risk: a time-varying relationship

Yang, G., Milne, G. L., Nogueira, M. S., Yi, H., Lan, Q., Gao, Y.-T., Shu, X.-o., Zheng, W., Chen, Q.

10.1101/2025.02.16.25322362 — Posted: 2025-02-20

Associations between residential segregation, ambient air pollution, and hippocampal features in recent trauma survivors

Liang, S. S., Roeckner, A. R., Ely, T. D., Lebois, L. A. M., van Rooij, S. J. H., Bruce, S. E., Jovanovic, T., House, S. L., Beaudoin, F. L., An, X., Neylan, T. C., Clifford, G. D., Linnstaedt, S. D., Germine, L. T., Rauch, S. L., Haran, J. P., Storrow, A. B., Lewandowski, C., Musey, P. I., Hendry, P. L., Sheikh, S., Pascual, J. L., Seamon, M. J., Harris, E., Pearson, C., Peak, D. A., Merchant, R. C., Domeier, R. M., Rathlev, N. K., O'Neil, B. J., Sergot, P., Sanchez, L. D., Sheridan, J. F., Harte, S. E., Kessler, R. C., Koenen, K. C., McLean, S. A., Ressler, K. J., Stevens, J. S., Webb, E. K.

10.1101/2025.02.18.25322464 — Posted: 2025-02-20

Polymeric Micellar Nanoparticles Enable Image-guided Drug Delivery in Solid Tumors

Uddin, M. J., Lo, J. H., Gupta, M. K., Werfel, T. A., Asaduzzaman, A., Oltman, C. G., Gbur, E. F., mohyuddin, m. T., nazmin, f., Rahman, M. S., Jashim, A., Crews, B. C., kingsley, p. J., Marnett, L. J., Duvall, C. L., Cook, R. S.

10.1101/2024.06.07.598019 — Posted: 2025-02-19

Discovering new amyloid-like peptides using all-atom simulations and artificial intelligence.

Kuang, X., Jalali, S., Rahman, T., Michalowski, J., Sheng-Wong, C., Wong-Ekkabut, J., Su, Z., Dias, C. L.

10.1101/2025.02.12.637911 — Posted: 2025-02-14

Genome-wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures

Kang, M., Ang, T. F. A., Devine, S. A., Sherva, R., Mukherjee, S., Trittschuh, E. H., Gibbons, L. E., Scollard, P., Lee, M., Choi, S.-E., Klinedinst, B., Nakano, C., Dumitrescu, L. C., Hohman, T. J., Cuccaro, M. L., Saykin, A. J., Kukull, W. A., Bennett, D. A., Wang, L.-S., Mayeux, R. P., Haines, J. L., Pericak-Vance, M. A., Schellenberg, G. D., Crane, P. K., Au, R., Lunetta, K. L., Mez, J., Farrer, L. A.

10.1101/2025.02.11.25322014 — Posted: 2025-02-13

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