Channel: Fred Hutchinson Cancer Center

This collection includes bioRxiv and medRxiv papers from authors at Fred Hutchinson Cancer Center.

1128 Articles

MLH1/3 variants causing aneuploidy, pregnancy loss, and premature reproductive aging

Singh, P., Fragoza, R., Blengini, C. S., Tran, T. N., Pannafino, G., Al-Sweel, N., Schimenti, K., Schindler, K., Alani, E., Yu, H., Schimenti, J. C.

10.1101/2021.01.14.426654 — Posted: 2021-01-15

Targeting glucose metabolism sensitizes pancreatic cancer to MEK inhibition

Yan, L., Tu, B., Yao, J., Gong, J., Carugo, A., Bristow, C., Wang, Q., Zhu, C., Dai, B., Kang, Y., Han, L., Feng, N., Jin, Y., Fleming, J., Heffernan, T., Yao, W., Ying, H.

10.1101/2021.01.09.425923 — Posted: 2021-01-11

Sustained IL-15 response signature predicts RhCMV/SIV vaccine efficacy

Barrenäs, F., Hansen, S. G., Law, L., Driscoll, C., Green, R. R., Smith, E., Chang, J., Golez, I., Urion, T., Peng, X., Whitmore, L., Newhouse, D., Hughes, C. M., Morrow, D., Randall, K. T., Selseth, A., Ford, J. C., Gilbride, R. M., Randall, B., Ainslie, E., Oswald, K., Shoemaker, R., Fast, R., Bosche, W. J., Axthelm, M. K., Fukazawa, Y., Pavlakis, G. N., Felber, B. K., Fourati, S., Sekaly, R.-P., Lifson, J. D., Komorowski, J., Kosmider, E., Shao, J., Song, W., Edlefsen, P. T., Picker, L. J., Gale, M.

10.1101/2021.01.11.426199 — Posted: 2021-01-11

BinomiRare: A carriers-only test for association of rare genetic variants with a binary outcome for mixed models and any case-control proportion

Sofer, T., Lee, J., Kurniansyah, N., Jain, D., Laurie, C. A., Gogarten, S. M., Conomos, M., Heavner, B., Hu, Y., Kooperberg, C., Haessler, J., Vasan, R. S., Cupples, L. A., Coombes, B. J., Seyerle, A., Gharib, S. A., Chen, H., O'Connell, J. R., Zhang, M., Gottlieb, D., Psaty, B. M., Longstreth, W. T., Rotter, J. I., Taylor, K. D., Rich, S. S., Guo, X., Boerwinkle, E., Morrison, A., Pankow, J., Johnson, A. D., Pankratz, N., NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, , Reiner, A. P., Redline, S., Smith, N. L., Rice, K. M., Shcifano, E. D.

10.1101/2021.01.08.21249450 — Posted: 2021-01-09

Cysteine is a limiting factor for glioma proliferation and survival

Larion, M., Ruiz-Rodado, V., Dowdy, T., Lita, A., Kramp, T., Zhang, M., Jung, J., Dios-Esponera, A., Herold-Mende, C. C., Camphausen, K., Gilbert, M. R.

10.1101/2021.01.08.425930 — Posted: 2021-01-08

Enhanced Solid Tumor Recognition and T cell Stemness with SynNotch CAR Circuits

Hyrenius-Wittsten, A., Su, Y., Park, M., Garcia, J. M., Perry, N., Montgomery, G., Liu, B., Roybal, K. T.

10.1101/2021.01.06.425642 — Posted: 2021-01-07

Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM

Shen, B. W., Quispe, J. D., Luyten, Y., McGeough, B. C., Morgan, R. D., Stoddard, B. L.

10.1101/2021.01.06.425610 — Posted: 2021-01-06

Chromatin Fiber Folding Represses Transcription and Loop Extrusion in Quiescent Cells

Swygert, S. G., Lin, D., Portillo-Ledesma, S., Lin, P.-Y., Hunt, D. R., Kao, C.-F., Schlick, T., Noble, W. S., Tsukiyama, T.

10.1101/2020.11.24.396713 — Posted: 2021-01-05

Whole genome sequencing association analysis of quantitative red blood cell phenotypes: the NHLBI TOPMed program

Hu, Y., Stilp, A. M., McHugh, C. P., Rao, S., Jain, D., Zheng, X., Lane, J., Meric de Bellefon, S., Laura, R. M., Chen, M.-H., Yanek, L. R., Wheeler, M., Yao, Y., Ren, C., Broome, J., Moon, J.-Y., de Vries, P. S., Hobbs, B. D., Sun, Q., Surendran, P., Brody, J. A., Blackwell, T. W., Choquet, H., Ryan, K., Duggirala, R., Heard-Costa, N., Wang, Z., Chami, N., Preuss, M. H., Min, N., Lynette, E., Lange, L. A., Cushman, M., Faraday, N., Curran, J. E., Almasy, L., Kundu, K., Smith, A. V., Gabriel, S., Rotter, J. I., Fornage, M., Lloyd-Jones, D. M., Vasan, R. S., Smith, N. L., North, K. E., Boerwink

10.1101/2020.12.09.20246736 — Posted: 2021-01-05

Whole Genome Sequence Association Analysis of Fasting Glucose and Fasting Insulin Levels in Diverse Cohorts from the NHLBI TOPMed Program

DiCorpo, D., Gaynor, S. M., Russell, E. M., Westerman, K. E., Raffield, L. M., Majarian, T. D., Wu, P., Sarnowski, C., Highland, H. M., Jackson, A., Hasbani, N. R., de Vries, P. S., Brody, J. A., Hidalgo, B., Guo, X., Perry, J. A., O'Connell, J. R., Lent, S., Montasser, M. E., Cade, B. E., Jain, D., Wang, H., D'Oliveira Albanus, R., Varshney, A., Yanek, L. R., Lange, L., Palmer, N. D., Almeida, M., Peralta, J. M., Aslibekyan, S., Baldridge, A. S., Bertoni, A. G., Bielak, L. F., Chen, C.-S., Chen, Y.-D. I., Choi, W. J., Goodarzi, M. O., Floyd, J. S., Irvin, M. R., Kalyani, R. R., Kelly, T., Lee

10.1101/2020.12.31.20234310 — Posted: 2021-01-04

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