Channel: Fred Hutchinson Cancer Center

This collection includes bioRxiv and medRxiv papers from authors at Fred Hutchinson Cancer Center.

1128 Articles

WHOLE GENOME SEQUENCING ANALYSIS OF BODY MASS INDEX IDENTIFIES NOVEL AFRICAN ANCESTRY-SPECIFIC RISK ALLELE

Zhang, X., Brody, J. A., Graff, M., Highland, H. M., Chami, N., Xu, H., Wang, Z., Ferrier, K., Chittoor, G., Josyula, N. S., Li, X., Li, Z., Allison, M. A., Becker, D. M., Bielak, L. F., Bis, J. C., Boorgula, M. P., Bowden, D. W., Broome, J. G., Buth, E. J., Carlson, C. S., Chang, K.-M., Chavan, S., Chiu, Y.-F., Chuang, L.-M., Conomos, M. P., DeMeo, D. L., Du, M., Duggirala, R., Eng, C., Fohner, A. E., Freedman, B. I., Garrett, M. E., Guo, X., Haiman, C., Heavner, B. D., Hidalgo, B., Hixson, J. E., Ho, Y.-L., Hobbs, B. D., Hu, D., Hui, Q., Hwu, C.-M., Jackson, R. D., Jain, D., Kalyani, R. R.

10.1101/2023.08.21.23293271 — Posted: 2023-08-22

Targeting CD19-positive lymphomas with the antibody-drug conjugate (ADC) loncastuximab tesirine: preclinical evidence as single agent and as combinatorial approach

Tarantelli, C., Wald, D., Munz, N., Spriano, F., Bruscaggin, A., Cannas, E., Cascione, L., Gaudio, E., Arribas, A. J., Manjappa, S., Golino, G., Scalise, L., Zucca, E., Stathis, A., Van Berkel, P. H., Rossi, D., Caimi, P. F., Zammarchi, F., Bertoni, F.

10.1101/2023.08.17.553668 — Posted: 2023-08-18

Unraveling the Global Proteome and Phosphoproteome of Prostate Cancer Patient-Derived Xenografts

Sychev, Z. E., Day, A., Bergom, H. E., Larson, G., Ali, A., Ludwig, M., Boytim, E., Ilsa, C., Corey, E., Plymate, S. R., Nelson, P. S., Hwang, J. H., Drake, J. M.

10.1101/2023.08.02.551697 — Posted: 2023-08-05

Critical Illness Risk and Long-Term Outcomes Following Intensive Care in Pediatric Hematopoietic Cell Transplant Recipients

Zinter, M. S., Brazauskas, R., Strom, J., Chen, S., Bo-Subait, S., Sharma, A., Beitinjaneh, A., Dimitrova, D., Guilcher, G., Preussler, J., Myers, K., Bhatt, N. S., Ringden, O., Hematti, P., Hayashi, R. J., Patel, S., Nakamura De Oliveira, S., Rotz, S., Badawy, S. M., Nishihori, T., Buchbinder, D., Hamilton, B., Savani, B., Schoemans, H., Sorror, M., Winestone, L., Duncan, C., Phelan, R., Dvorak, C. C.

10.1101/2023.07.31.23293444 — Posted: 2023-08-05

Jointly modeling deep mutational scans identifies shifted mutational effects among SARS-CoV-2 spike homologs

Haddox, H. K., Galloway, J. G., Dadonaite, B., Bloom, J. D., Matsen, F. A., DeWitt, W. S.

10.1101/2023.07.31.551037 — Posted: 2023-08-02

Surprising connections between DNA binding and function for the near-complete set of yeast transcription factors

Mahendrawada, L., Warfield, L., Donczew, R., hahn, s.

10.1101/2023.07.25.550593 — Posted: 2023-08-01

A multiplex, prime editing framework for identifying drug resistance variants at scale

Chardon, F. M., Suiter, C., Daza, R., Smith, N. T., Parrish, P., McDiarmid, T., Lalanne, J.-B., Martin, B. K., Calderon, D., Ellison, A., Berger, A., Shendure, J., Starita, L. M.

10.1101/2023.07.27.550902 — Posted: 2023-07-30

TGF-β broadly modifies rather than specifically suppresses reactivated memory CD8 T cells in a dose-dependent manner

Taber, A., Konecny, A., Scott-Browne, J., Prlic, M.

10.1101/2023.07.27.550871 — Posted: 2023-07-29

A CRISPR screen of HIV dependency factors reveals CCNT1 is non-essential in T cells but required for HIV-1 reactivation from latency

Hafer, T. L., Felton, A., Delgado, Y., Srinivasan, H., Emerman, M.

10.1101/2023.07.28.551016 — Posted: 2023-07-28

Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus

Kwak, S. H., Cohorts for Heart & Aging Research in Genomic Epidemiology (CHARGE) consortium, , Hernandez-Cance, R., DiCorpo, D., Condon, D., Merino, J., Wu, P., Brody, J. A., Yao, J., Guo, X., Ahmadizar, F., Meyer, M., Sincan, M., Mercader, J. M., Lee, S., Haessler, J., Vy, H. M. T., Lin, Z., Armstrong, N. D., Gu, S., Tsao, N., Lange, L. A., Wang, N., Wiggins, K. L., Trompet, S., Liu, S., Loos, R. J. F., Judy, R., Schroeder, P. H., Hasbani, N. R., Bos, M. M., Morrison, A. C., jackson, R. D., Reiner, A. P., Manson, J. E., Chaudhary, N. S., Carmichael, L. K., Chen, Y.-D. I., Taylor, K. D., Ghan

10.1101/2023.07.25.23293180 — Posted: 2023-07-28

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