Channel: Fred Hutchinson Cancer Center

This collection includes bioRxiv and medRxiv papers from authors at Fred Hutchinson Cancer Center.

1450 Articles

An international, inter-laboratory ring trial confirms the feasibility of an open source, extraction-less "direct" RT-qPCR method for reliable detection of SARS-CoV-2 RNA in clinical samples

Mills, M. G., Bruce, E. A., Huang, M.-L., Crothers, J. W., Hyrien, O., Oura, C. A. L., Blake, L., Brown, A., Hester, S., Wehmas, L., Mari, B., Barby, P., Lacoux, C., Fassy, J., Vial, P., Vial, C., Martinez, J. R., Oladipo, O. O., Inuwa, B., Shittu, I., Meseko, C. A., Chammas, R., Ferreira Santos, C., Dionisio, T. J., Garbieri, T. F., Parisi, V. A., Mendes-Correa, M. C., dePaula, A. V., Romano, C. M., Bentim Goes, L. G., Minoprio, P., Campos, A. C., Cunha, M. P., Vilela, A. P. P., Nyirenda, T., Sawasawa Mkakosya, R., Muula, A. S., Dumm, R. E., Harris, R. M., Mitchell, C. A., Pettit, S., Botten

10.1101/2021.04.10.21254091 — Posted: 2021-04-16

Optimizing vaccine allocation for COVID-19 vaccines: potential role of single-dose vaccination.

Matrajt, L., Eaton, J., Leung, T., Dimitrov, D., Schiffer, J. T., Swan, D. A., Janes, H.

10.1101/2020.12.31.20249099 — Posted: 2021-04-15

The SARS-CoV-2 mRNA-1273 vaccine elicits more RBD-focused neutralization, but with broader antibody binding within the RBD

Greaney, A. J., Loes, A. N., Gentles, L. E., Crawford, K. H., Starr, T. N., Malone, K. D., Chu, H. Y., Bloom, J. D.

10.1101/2021.04.14.439844 — Posted: 2021-04-14

Multipotent progenitors and hematopoietic stem cells arise independently during the endothelial to hematopoietic transition in the early mouse embryo

Dignum, T., Varnum-Finney, B., Srivatsan, S., Dozono, S., Waltner, O., Heck, A., Nourigat-McKay, C., Jackson, D. L., Rafii, S., Trapnell, C., Bernstein, I. D., Hadland, B. K.

10.1101/2021.04.13.439736 — Posted: 2021-04-14

Polypharmacological Re-programming of Tumor-associated Macrophages Restores Antitumor Immunity

Nishida-Aoki, N., Gujral, T. S.

10.1101/2021.04.10.439265 — Posted: 2021-04-11

Machine Learning Identifies Ponatinib as a Potent Inhibitor of SARS-CoV2-induced Cytokine Storm

Chan, M., Vijay, S., McElrath, M. J., Holland, E. C., Gujral, T. S.

10.1101/2021.04.07.438871 — Posted: 2021-04-09

Aljedani, S., Liban, T. J., Tran, K., Phad, G., Singh, S., Dubrovskaya, V., Pushparaj, P., Martinez-Murillo, P., Rodarte, J., Mileant, A., Mangala, V., Kinzelman, R., O'Dell, S., Mascola, J. R., Lee, K. K., Karlsson Hedestam, G. B., Wyatt, R. T., Pancera, M.

10.1101/2021.04.09.439148 — Posted: 2021-04-09

Structural basis for broad sarbecovirus neutralization by a human monoclonal antibody

Tortorici, M. A., Czudnochowski, N., Starr, T. N., Marzi, R., Walls, A. C., Zatta, F., Bowen, J. E., Jaconi, S., di Iulio, J., Wang, Z., De Marco, A., Zepeda, S., Pinto, D., Liu, Z., Beltramello, M., Bartha, I., Housley, M. P., Lempp, F. A., Rosen, L. E., Dellota, E., Kaiser, H., Montiel-Ruiz, M., Zhou, J., Addetia, A., Guarino, B., Culap, K., Sprugasci, N., Saliba, C., Vetti, E., Giacchetto-Sasselli, I., Silacci Fregni, C., Abdelnabi, R., Foo, C. S.-Y., Havenar-Daughton, C., Schmid, M. A., Benigni, F., Cameroni, E., Neyts, J., Telenti, A., Snell, G., Virgin, H. W., Whelan, S. P. J., Bloom, J.

10.1101/2021.04.07.438818 — Posted: 2021-04-08

Antibodies to the SARS-CoV-2 receptor-binding domain that maximize breadth and resistance to viral escape

Starr, T. N., Czudnochowski, N., Zatta, F., Park, Y.-J., Liu, Z., Addetia, A., Pinto, D., Beltramello, M., Hernandez, P., Greaney, A. J., Marzi, R., Glass, W. G., Zhang, I., Dingens, A. S., Bowen, J. E., Wojcechowskyj, J. A., De Marco, A., Rosen, L. E., Zhou, J., Montiel-Ruiz, M., Kaiser, H., Tucker, H., Housley, M. P., Di Iulio, J., Lombardo, G., Agostini, M., Sprugasci, N., Culap, K., Jaconi, S., Meury, M., Dellota, E., Cameroni, E., Croll, T. I., Nix, J. C., Havenar-Daughton, C., Telenti, A., Lempp, F. A., Pizzuto, M. S., Chodera, J. D., Hebner, C. M., Whelan, S. P., Virgin, H. W., Veesler

10.1101/2021.04.06.438709 — Posted: 2021-04-08

Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19

Klaric, L., Gisby, J. S., Papadaki, A., Muckian, M. D., Macdonald-Dunlop, E., Zhao, J. H., Tokolyi, A., Persyn, E., Pairo-Castineira, E., Morris, A. P., Kalnapenkis, A., Richmond, A., Landini, A., Hedman, A. K., Prins, B., Zanetti, D., Wheeler, E., Kooperberg, C., Yao, C., Petrie, J. R., Fu, J., Folkersen, L., Walker, M., Magnusson, M., Eriksson, N., Mattsson-Carlgren, N., Timmers, P. R., Hwang, S.-J., Enroth, S., Gustafsson, S., Vosa, U., Chen, Y., Siegbahn, A., Reiner, A., Johansson, A., Thorand, B., Gigante, B., Hayward, C., Herder, C., Gieger, C., Langenberg, C., Levy, D., Zhernakova, D. V

10.1101/2021.04.01.21254789 — Posted: 2021-04-07

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