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Shifting the PPARγ conformational ensemble towards a transcriptionally repressive state improves covalent inhibitor efficacy
Arifova, L., MacTavish, B. S., Laughlin, Z., Karadi Girdhar, M. N., Shang, J., Li, M.-H., Yu, X., Zhu, D., Kamenecka, T. M., Kojetin, D.
10.1101/2025.03.04.640448 — Posted: 2025-03-05 — Discussion: 2025-12-31  eLife
Efficiency and localisation of AURKA degradation by PROTACs is modulated by deubiquitinases UCHL5 and target-selective OTUD6A
Cardno, A., Roberts, K., Lindon, C.
10.1101/2025.04.23.650020 — Posted: 2025-04-23 — Discussion: 2025-12-31  eLife
Differential Regulation of Hepatic Macrophage Fate by Chi3l1 in MASLD
He, J., Chen, B., Wang, X., Yang, R., Deng, C., Zhu, X., Wang, K., Wang, L., Lu, X., Peng, C., Li, C., Shan, Z.
10.1101/2025.05.06.652369 — Posted: 2025-05-06 — Discussion: 2025-12-31  eLife
Single-Cell Characterization of Anterior Segment Development: Cell Types, Pathways, and Signals Driving Formation of the Trabecular Meshwork and Schlemm's Canal
Balasubramanian, R., Tolman, N., Li, T., Hannan, A., Bupp-Chickering, V., Polanco, K., Bhandari, A., Zhou, S., Simon, M., Peregrin, J., Montgomery, C., Kizhatil, K., Qian, J., John, S.
10.1101/2025.08.15.670438 — Posted: 2025-08-21 — Discussion: 2025-12-31  eLife
PH sensitivity of cerebrospinal fluid-contacting neurons involves the modulation of phasic and tonic currents mediated by PKD2L1 channels located in the apical process.
Vitar, M., Prieto, D., Malas, S., Russo, R. E., Trigo, F. F.
10.1101/2025.08.24.671961 — Posted: 2025-08-27 — Discussion: 2025-12-31  eLife
A conserved Hsp70 phosphorylation regulates cell cycle progression after DNA damage
Moss, T., Wooldredge, A., Bhakta, K., Cronin, M., Gestwicki, J. E., Mukherjee, S.
10.1101/2025.09.05.672953 — Posted: 2025-09-06 — Discussion: 2025-12-31  eLife
The livebearers platyfish and swordtails partially regenerate their hearts with persistent scarring
Hisler, V., Rees, L., Blanchoud, S., Lischer, H. E. L., Bruggmann, R., Jazwinska, A.
10.1101/2025.09.23.678041 — Posted: 2025-09-25 — Discussion: 2025-12-31  eLife
A dual role for PGLYRP1 in host defense and immune regulation during B. pertussis infection
Rickert, D. M., Cardozo, S., Carbonetti, N., Goldman, W. E., Scanlon, K. M., Skerry, C.
10.1101/2025.09.26.678899 — Posted: 2025-09-27 — Discussion: 2025-12-31  eLife
Fragile nucleosomes are essential for RNA Polymerase II to transcribe in eukaryotes
Li, L., Hunter, S., Leach, S., Zhuang, Y., Liu, H., Gao, J., Zhang, Q., Stasevich, T. J., Kimura, H., Dowell, R. D., Zhang, G.
10.1101/2025.10.08.681188 — Posted: 2025-10-11 — Discussion: 2025-12-31  eLife
Direct MRI of Collagen
Van Schoor, J. D., Weiger, M., Pruessmann, K. P., Baadsvik, E. L.
10.1101/2025.11.24.690130 — Posted: 2025-11-26 — Discussion: 2025-12-31  eLife

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