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Large scale prospective evaluation of co-folding across 557 Mac1-ligand complexes and three virtual screens
Kim, J., Correy, G. J., Hall, B. W., Rachman, M. M., Mailhot, O., Togo, T., Gonciarz, R. L., Jaishankar, P., Neitz, R. J., Hantz, E. R., Doruk, Y. U., Stevens, M. G. V., Diolaiti, M. E., Reid, R., Gopalkrishnan, S., Krogan, N. J., Renslo, A. R., Ashworth, A., Shoichet, B. K., Fraser, J. S.
10.64898/2025.12.25.696505 — Posted: 2025-12-28 — Discussion: 2026-05-26  eLife
Molidustat Targets a Synthetic Lethal Vulnerability in APC-Mutant Colorectal Cancer through GSTP1 and PHD2 Co-Inhibition
Asselborn, C., Makar, A. N., Marques, J. G., Akan, A. B., Yiapanas, A., Jennings, C., Perez Lopez, A., Wills, J., Unciti-Broceta, A., Myant, K. B., von Kriegsheim, A.
10.64898/2026.01.31.702998 — Posted: 2026-02-03 — Discussion: 2026-05-26  eLife
Real-Time Embodied Experience Shapes High-Level Reasoning Under Altered Gravity
Grandchamp des Raux, H., Ghilardi, T., Ferre, E. R., Ossmy, O.
10.64898/2026.03.16.712090 — Posted: 2026-03-20 — Discussion: 2026-05-26  eLife
SPEx: Compartment-Resolved Proteomics via Expansion Microscopy-Guided Microdissection
Franziscus, C. A., Ferrand, A., Biehlmaier, O., Schmidt, A., Spang, A.
10.64898/2026.03.28.714993 — Posted: 2026-03-30 — Discussion: 2026-05-26  eLife
Two Glu/Asp Residues Cooperatively Mediate an Early Step of ATP Hydrolysis in GHKL ATPases MutL and GyrB
Fukui, K., Shibuya, A., Murakawa, T., Yano, T.
10.64898/2026.03.31.715682 — Posted: 2026-04-01 — Discussion: 2026-05-26  eLife
A comprehensive dimensional reduction framework to learn single-cell phenotypic topology uncovers T cell diversity
Sidarta-Oliveira, D., Velloso, L. A.
10.1101/2022.03.14.484134 — Posted: 2022-03-17 — Discussion: 2026-05-22  eLife
Loose coupling between Ca2+ channels and release sensors as a synaptic correlate of higher order brain function
Schwarze, M., Bornschein, G., Brunner, A., Arshia, A., Brachtendorf, S., Schmidt, H.
10.64898/2025.12.15.694355 — Posted: 2025-12-16 — Discussion: 2026-05-22  eLife
Repurposed small molecule toxin inhibitors neutralise a diversity of venoms from the Neotropical viperid snake genus Bothrops
Clare, R. H., Westhorpe, A., Stars, E., Kazandjian, T. D., Albulescu, L.-O., Menzies, S. K., Casewell, N. R.
10.64898/2026.01.02.697350 — Posted: 2026-01-02 — Discussion: 2026-05-22  eLife
Endocardial TIE1 synergizes with TIE2 to regulate the atrial internal muscular network assembly
Ding, K., Xu, B., Yu, X., Jia, X., Li, T., Shen, X., Li, J., Cao, X., Liu, Y., Zhang, Z., He, Y.
10.64898/2026.02.26.708190 — Posted: 2026-02-28 — Discussion: 2026-05-22  eLife
Estimating probabilities of malaria importation in southern Mozambique through P. falciparum genomics and mobility patterns
Pujol, A., Chidimatembue, A., da Silva, C., Boene, S., Mbeve, H., Cistero, P., Garcia-Fernandez, C., Vano-Boira, A., Tembisse, D., Inacio, J., Matambisso, G., Luis, F., Ndimande, N., Munguambe, H., Nhamussua, L., Simone, W., Aranda-Diaz, A., Garcia-Ulloa, M., Canana, N., Tusell, M., Montana, J., Fuente-Soro, L., Bapu, K. U., Murphy, M., Rafael, B., Rovira-Vallbona, E., Guinovart, C., Greenhouse, B., Enosse, S. M., Saute, F., Aide, P., Candrinho, B., Mayor, A.
10.1101/2025.05.01.25326793 — Posted: 2025-05-02 — Discussion: 2026-05-22  eLife

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