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7,782 Reviews — eLife — All Subjects

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Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity
Mancl, J. M., Liang, w. G., bayhi, N. L., Wei, H., Carragher, B., Potter, C. S., Tang, W.-J.
10.1101/2024.12.30.630732 — Posted: 2024-12-30 — Discussion: 2025-11-18  eLife
Molecular mechanism for cargo-mediated initiation of kinesin-1 activation
Shukla, S., Cross, J. A., Kish, M., Yadav, S. K., Weijman, J. F., O'Regan, L., Mantell, J., Borucu, U., Leng, X., Schaffitzel, C., Phillips, J. J., Woolfson, D. N., Dodding, M. P.
10.1101/2025.04.08.647705 — Posted: 2025-04-08 — Discussion: 2025-11-18  eLife
Male-Biased Cyp17a2 Governs Antiviral Sexual Dimorphism in Fish via STING Stabilization and Viral Protein Degradation
Lu, L.-F., Cui, B.-j., Shi, S.-C., Wang, Y.-Y., Zhang, C., Xu, X., Tian, M.-Z., Li, Z.-Q., Xu, N., Li, Z.-C., Chen, D.-D., Zhou, L., Zhai, G., Yin, Z., Li, S.
10.1101/2025.06.23.661124 — Posted: 2025-06-27 — Discussion: 2025-11-18  eLife
Ptbp1 is not required for retinal neurogenesis and cell fate specification.
Appel, H., Carmen-Orozco, R., Santiago, C., Hoang, T., Blackshaw, S.
10.1101/2025.07.02.662808 — Posted: 2025-07-03 — Discussion: 2025-11-18  eLife
Multi-barrier unfolding of the double-knotted protein, TrmD-Tm1570, revealed by single-molecule force spectroscopy and molecular dynamics
Bruno da Silva, F., Niewieczerzal, S., Lewandowska, I., Sikora, M., Silbermann, L.-M., Tych, K. M., Sulkowska, J. I.
10.1101/2025.08.27.672562 — Posted: 2025-08-29 — Discussion: 2025-11-18  eLife
Role of tankyrase scaffolding in the β-catenin destruction complex and WNT signaling
Wang, Q., Li, L., You, L., Wang, S., Han, L., Wang, B., Yao, L., Lu, Y., Mender, I., Flusche, A. M., Kim, C., Yarravarapu, N., Lemoff, A., Lum, L., Shay, J. W., Yu, Y., Chen, C.
10.1101/2025.09.22.677768 — Posted: 2025-09-24 — Discussion: 2025-11-18  eLife
Genomic privacy risks in GWAS summary statistics
Lan, A., Pawitan, Y., Shen, X.
10.1101/2025.09.09.25335252 — Posted: 2025-09-12 — Discussion: 2025-11-18  eLife
WNKs regulate mouse behavior and alter central nervous system glucose uptake and insulin signaling
Jaykumar, A. B., Binns, D., Taylor, C. A., Anselmo, A., Birnbaum, S. G., Huber, K. M., Cobb, M. H.
10.1101/2024.06.09.598125 — Posted: 2024-06-10 — Discussion: 2025-11-17  eLife
Investigation of All Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis
Shimogawa, M., Li, M.-H., Park, G. S. H., Ramirez, J., Lee, H., Watson, P., Sharma, S., Lin, Z., Peng, C., Christianson, D. W., Eliezer, D., Rhoades, E., Petersson, E. J.
10.1101/2025.01.21.634178 — Posted: 2025-01-22 — Discussion: 2025-11-17  eLife
Identification and classification of ion-channels across the tree of life: Insights into understudied CALHM channels
Taujale, R., Park, S. J., Gravel, N., Soleymani, S., Carter, R., Boyd, K., Keuning, S., Ruan, Z., Lü, W., Kannan, N.
10.1101/2025.02.10.637530 — Posted: 2025-02-18 — Discussion: 2025-11-17  eLife

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