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A giant leap in sequence space reveals the intracellular complexities of evolving a new function
Hall, K. R., Robins, K. J., Rich, M. H., Calcott, M. J., Copp, J., Williams, E. M., Little, R. F., Schwörer, R., Evans, G. B., Patrick, W. M., Ackerley, D. F.
10.1101/2020.05.27.118489 — Posted: 2020-05-30 — Discussion: 2020-07-20  eLife
Cell-to-cell and genome-to-genome variability of Adenovirus transcription tuned by the cell cycle
Suomalainen, M., Prasad, V., Kannan, A., Greber, U. F.
10.1101/2020.02.27.967471 — Posted: 2020-02-27 — Discussion: 2020-07-19  Review Commons
Targeted gene correction of FKRP by CRISPR/Cas9 restores functional glycosylation of α-dystroglycan in cortical neurons derived from human induced pluripotent stem cells
Lana, B., Kim, J., Ryan, D., Konstantinidis, E., Louzada, S., Fu, B., Yang, F., Stemple, D. L., Liu, P., Muntoni, F., Lin, Y.-Y.
10.1101/101352 — Posted: 2017-01-18 — Discussion: 2020-07-15  EMBO Press
Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR)
Dong, R., Libby, K. A., Blaeschke, F., Marson, A., Vale, R. D., Su, X.
10.1101/2019.12.19.883496 — Posted: 2019-12-20 — Discussion: 2020-07-15  EMBO Press
Temporal specificity and heterogeneity of the fly immune cells' transcriptional landscape
Cattenoz, P. B., Sakr, R., Pavlidaki, A., Delaporte, C., Riba, A., Molina, N., Hariharan, N., Mukherjee, T., Giangrande, A.
10.1101/2019.12.20.871301 — Posted: 2019-12-20 — Discussion: 2020-07-15  EMBO Press
A general role of zinc binding domain revealed by structures of σ28-dependent transcribing complexes
Shi, W., Zhou, W., Zhang, B., Huang, S., Jiang, Y., Schammel, A., Hu, Y., Liu, B.
10.1101/2020.01.02.893370 — Posted: 2020-01-03 — Discussion: 2020-07-15  EMBO Press
Drug mechanism-of-action discovery through the integration of pharmacological and CRISPR screens
Goncalves, E., Segura-Cabrera, A., Pacini, C., Picco, G., Behan, F., Jaaks, P., Coker, E. A., van der Meer, D., Barthorpe, A., Lightfoot, H., Leach, A. R., Lynch, J. T., Sidders, B., Crafter, C., Iorio, F., Fawell, S., Garnett, M. J.
10.1101/2020.01.14.905729 — Posted: 2020-01-14 — Discussion: 2020-07-15  EMBO Press
Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cells
Muralidharan, S. V., Nilsson, L. M., Lindberg, M. F., Nilsson, J. A.
10.1101/2020.01.21.913467 — Posted: 2020-01-21 — Discussion: 2020-07-15  EMBO Press
Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA
Walden, H., Rennie, M. L., Lemonidis, K., Arkinson, C., Chaugule, V. K., Clarke, M., Streetley, J., Spagnolo, L.
10.1101/2020.02.03.931576 — Posted: 2020-02-03 — Discussion: 2020-07-15  EMBO Press
CRISPR-TAPE: protein-centric CRISPR guide design for targeted proteome engineering
Anderson, D. P., Benns, H. J., Tate, E. W., Child, M. A.
10.1101/2020.02.26.965889 — Posted: 2020-02-26 — Discussion: 2020-07-15  EMBO Press

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