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A general role of zinc binding domain revealed by structures of σ28-dependent transcribing complexes
Shi, W., Zhou, W., Zhang, B., Huang, S., Jiang, Y., Schammel, A., Hu, Y., Liu, B.
10.1101/2020.01.02.893370 — Posted: 2020-01-03 — Discussion: 2020-07-15  EMBO Press
Drug mechanism-of-action discovery through the integration of pharmacological and CRISPR screens
Goncalves, E., Segura-Cabrera, A., Pacini, C., Picco, G., Behan, F., Jaaks, P., Coker, E. A., van der Meer, D., Barthorpe, A., Lightfoot, H., Leach, A. R., Lynch, J. T., Sidders, B., Crafter, C., Iorio, F., Fawell, S., Garnett, M. J.
10.1101/2020.01.14.905729 — Posted: 2020-01-14 — Discussion: 2020-07-15  EMBO Press
Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cells
Muralidharan, S. V., Nilsson, L. M., Lindberg, M. F., Nilsson, J. A.
10.1101/2020.01.21.913467 — Posted: 2020-01-21 — Discussion: 2020-07-15  EMBO Press
Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA
Walden, H., Rennie, M. L., Lemonidis, K., Arkinson, C., Chaugule, V. K., Clarke, M., Streetley, J., Spagnolo, L.
10.1101/2020.02.03.931576 — Posted: 2020-02-03 — Discussion: 2020-07-15  EMBO Press
CRISPR-TAPE: protein-centric CRISPR guide design for targeted proteome engineering
Anderson, D. P., Benns, H. J., Tate, E. W., Child, M. A.
10.1101/2020.02.26.965889 — Posted: 2020-02-26 — Discussion: 2020-07-15  EMBO Press
The lupus autoantigen La is an Xist-binding RNA chaperone involved in Xist folding and cloud formation
Ha, N., Ding, N., Hong, R., Liu, R., Roca, X., Luo, Y., Duan, X., Wang, X., Zhang, L.-F., Chen, L.
10.1101/2020.03.07.981860 — Posted: 2020-03-08 — Discussion: 2020-07-15  Review Commons
Lipid-associated PML domains regulate CCTα, Lipin1 and lipid homeostasis
Lee, J., Salsman, J., Foster, J., Dellaire, G., Ridgway, N.
10.1101/2020.03.10.986380 — Posted: 2020-03-11 — Discussion: 2020-07-15  EMBO Press
Identification and characterization of diverse OTU deubiquitinases in bacteria
Schubert, A. F., Nguyen, J. V., Franklin, T. G., Geurink, P. P., Roberts, C. G., Sanderson, D. J., Miller, L. N., Ovaa, H., Hofmann, K., Pruneda, J. N., Komander, D.
10.1101/2020.03.28.013474 — Posted: 2020-03-29 — Discussion: 2020-07-15  EMBO Press
An unexpected contribution of lincRNA splicing to enhancer function.
Tan, J. Y., Biasini, A., Young, R. S., Marques, A.
10.1101/287706 — Posted: 2018-03-23 — Discussion: 2020-07-15  EMBO Press
EZH2 co-opts gain-of-function p53 mutants to promote cancer growth and metastasis
Zhao, Y., Ding, L., Wang, D., Ye, Z., Pan, Y., Ma, L., Coleman, R., Coleman, I., Karnes, R. J., Zhang, J., Nelson, P. S., Wang, L., Zhu, R., Huang, H.
10.1101/298737 — Posted: 2018-04-10 — Discussion: 2020-07-15  EMBO Press

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