Channel:  Francis Crick Institute

1103 Articles

Epigenetic investigation of multifocal small intestinal neuroendocrine tumours reveals accelerated ageing of tumours and epigenetic alteration of metabolic genes
Webster, A. P., Makinen, N., Mensah, N., Castignani, C., Larose Cadieux, E., Shivdasani, R., Singh, P., Vaikkinen, H., Dhami, P., Ecker, S., Brown, M., Rimmer, B., Henderson, S., Herrero, J., Suderman, M., Yousefi, P. D., Beck, S., Van Loo, P., Nakakura, E., Thirlwell, C.
10.1101/2024.12.02.626017 — Posted: 2024-12-05
The essential host genome for Cryptosporidium intracellular survival exposes metabolic dependencies that can be leveraged for treatment
Marzook, N. B., Song, O.-R., Baumgärtel, L., Bernitz, N., Mkandawire, T. T., Watson, L. C., Nunes, V., Warchal, S., MacRae, J. I., Howell, M., Sateriale, A.
10.1101/2024.12.04.626561 — Posted: 2024-12-05
Spherical Phenotype Clustering
Nightingale, L., Tuersley, J., Cairoli, A., Howes, J., Shand, C., Powell, A., Green, D., Strange, A., Warchal, S., Howell, M.
10.1101/2024.04.19.590313 — Posted: 2024-12-05
HIFalpha isoform specific activities drive cell-type specificity of VHL-associated oncogenesis
Lima, J. D. C. C., Hooker, M., Li, R., Barros, A. B., Masson, N., Pugh, C. W., Mole, D. R., Adam, J., Ratcliffe, P. J., Kurlekar, S.
10.1101/2024.11.28.625663 — Posted: 2024-12-03
Cross-tissue isoform switches by human transcription factors suggest a widespread regulatory mechanism
Sidorov, S., Pal, K., Lenhard, B., Luscombe, N. M.
10.1101/2024.11.28.625692 — Posted: 2024-11-29
Sensing of extracellular L-Proline availability by the integrated stress response determines the outcome of cell competition.
Krishnan, S., Lima, A., Low, Y. T., Montero, S. P., Tan, S., Gregorio, A. D., Barreto, A. P., Bowling, S., Vousden, K., Rodriguez, T. A.
10.1101/2024.11.28.625863 — Posted: 2024-11-28
Sex chromosomes shape the transcriptional landscape of the preimplantation mouseembryo
Snell, D. M., Varsally, W., Courtois, A., Menchero, S., Munusamy, P., Rietdijk, R., Ojarikre, O. A., Strohbuecker, S., Kaya, H., Sangrithi, M. N., Turner, J. M.
10.1101/2024.11.26.625424 — Posted: 2024-11-26
Integration of hunger and hormonal state gates infant-directed aggression
Cao, M., Ammari, R., Chen, M. X., Wai, P., Sahni, A., Liang, S., Legrave, N., MacRae, J. I., Strom, M., Kohl, J.
10.1101/2024.11.25.625278 — Posted: 2024-11-25
The ALS- and FTD-associated proteins Annexin A11 and CHMP2B act sequentially in membrane repair
Heffner, C. M., Starling, G. P., Isaacs, A., Carlton, J. G.
10.1101/2024.11.19.624330 — Posted: 2024-11-25
Targeted CRISPR Screens Reveal Genes Essential for Cryptosporidium Survival in the Host Intestine
Watson, L. C., Sala, K. A., Bernitz, N., Baumgartel, L., Pallett, M. A., Marzook, N. B., Straker, L. C., Peng, D., Collinson, L., Sateriale, A.
10.1101/2024.11.22.624643 — Posted: 2024-11-22

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