Channel:  Francis Crick Institute

1,334 Articles

Multi-Species, Genome-Wide Metabolic Network Reconstructions Reveal the Basis for Metabolic Versatility in Mycobacteria
Cancino Aguirre, I., Priya, M., Garza-Garcia, A., de Carvalho, L. P. S., de Jong, H., Ropers, D.
10.64898/2026.09.02.748904 — Posted: 2026-09-04
Cholesterol and p53 promote senescence and systemic fibrosis in metabolic dysfunction-associated steatohepatitis
Wittke, C. I., Watt, D. M., Butler, L., Lyons, A. M., Clarke, C. J., Mullen, C., Clements, N., Lawlor, A., Athineos, D., Young, A., Strathdee, D. J., Nixon, C., Nelson, L. J., Bird, T. G., Vousden, K. H., Blyth, K., Crowe, J., Humpton, T. J.
10.64898/2026.09.02.748892 — Posted: 2026-09-03
Starvation improves epithelial fitness by selectively extruding DNA damaged cells
Gates, L. A., Bagley, D. C., Carlton, J. G., Rosenblatt, J.
10.64898/2026.09.01.748489 — Posted: 2026-09-02
iClima: a ratiometric genetically encoded sensor for optical imaging of fast GABAergic chloride currents in vitro and in vivo
Pasquini, G., Giubbolini, S., Nardi, G., Brondi, M., Beyene, E., Balsi, C., Egidi, A., Tsushima Semini, H., Landi, S., Stancampiano, M., Beale, A. D., Watson, E. M., Edgar, R. S., ONeill, J. S., Arosio, D., Santi, M., Fassio, A., Lodovichi, C., Ratto, G. M.
10.64898/2026.05.27.728254 — Posted: 2026-09-02
A COJEC-chemotherapy resistant model of Th-ALK(F1174L)/MYCN neuroblastoma offers insights into tumour immune evasion and development of the bone marrow metastatic niche
Tucker, E. R., Lampis, A., Househam, J., Roberts, D., Barker, K., Martins da Costa, B., Greenslade, K., Mayfield, S., Lorenzi, F., Thorley, E., Tandon, V., Han, N. S., Emanuelli, G., Bourdim, M., Martin, G., Willumsen, N., Pannone, M., Pryce, J., Angelini, P., Yuneva, M., Graham, T., George, S. L., Chesler, L.
10.64898/2026.09.01.743331 — Posted: 2026-09-02
Thymic keratin76 shapes skin-specific central tolerance
Gelmetti, M., Tomas, I. M., Ragazzini, R., Campinoti, S., Soon, M. S. F., Cautela, M., Vietri Rudan, M., Torre, M., Sumaria, N., Saldanha, I., Pereira, D., Yap, N., Efremova, M., Tuong, Z. K., Watt, F. M., Bonfanti, P., Pennington, D. J., Sequeira, I.
10.64898/2026.08.27.747460 — Posted: 2026-08-31
The mTOR pathway drives daily physiology
Zeng, A., Mihut, A., Anandapadamanaban, M., Goity, A., de Barros Dantas, L. L., Peak Chew, S.-Y., Hayter, E. A., Andersson, L. C., Smith, T., Seinkmane, E., Stangherlin, A., James, N. R., Beresford, C., Farnsworth, J., Menzies, J., al-Rawi, A., Holt, L. J., Derivery, E., Edgar, R. S., Madsen, R. R., Bechtold, D. A., Larrondo, L. F., Dodd, A. N., Rihel, J., Ratto, G. M., Williams, J., Newham, P., Hilgendorf, C., Beale, A. D., Lodovichi, C., O'Neill, J. S.
10.64898/2026.08.28.747564 — Posted: 2026-08-31
Single-cell mapping of the fallopian tube reveals a genomically unstable secretory cell state enriched in carriers of germline BRCA1/2 mutations
Eyal-Lubling, Y., Vias, M. D., Kania, K., Kaludova, D., Hall, J., Crawford, R., Nyagumbo, R., Ward, S., Khoronenkova, S., Aparicio, S., Swanton, C., Jimenez Linan, M., Brenton, J. D., Correia Martins, F.
10.64898/2026.08.26.746998 — Posted: 2026-08-27
Piezo1 balances focal and reticular adhesions to enable EGFR clathrin-mediated endocytosis
Bagudanch, O., Zoroa, O., Ayala, V., Midyan, R., Bagley, D. C., Moparthi, S. B., Hakanpää, L., Lenaerts, A.-S., Almeida-Souza, L., Munoz, F. J., Valverde, M. A., Vassilopoulos, S., Rosenblatt, J., Pardo-Pastor, C.
10.64898/2026.08.21.746250 — Posted: 2026-08-24
Chromosomal instability shapes spatial and temporal phenotypic diversity in a malignant peripheral nerve sheath tumour
Yan, H., Demeulemeester, J., Verfaillie, A., Cheng, Y., Pan, Y., Cotobal Martin, C., Ward, S., Stein, A., Lesluyes, T., Kaufmann, T., Schwarz, R. F., Voet, T., Swanton, C., Zaccaria, S., Flanagan, A. M., Tarabichi, M., Van Loo, P.
10.64898/2026.08.13.744699 — Posted: 2026-08-21

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