Channel:  Francis Crick Institute

1,171 Articles

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Two-color coincidence single-molecule pull-down for the specific detection of disease-associated protein aggregates
Saleeb, R. S., Leighton, C., Lee, J.-E., O'Shaughnessy, J., Jeacock, K., Chappard, A., Cumberland, R., Ball, S. R., Sunde, M., Clarke, D. J., Piche, K., McPhail, J. A., Louwrier, A., Angers, R., Gandhi, S., Downey, P., Kunath, T., Horrocks, M. H.
10.1101/2023.06.27.546642 — Posted: 2023-06-29
Comparative analysis of N-terminal cysteine dioxygenation and prolyl-hydroxylation as oxygen sensing pathways in mammalian cells
Tian, Y.-M., Holdship, P., To, T. Q., Ratcliffe, P. J., Keeley, T. P.
10.1101/2023.06.25.545688 — Posted: 2023-06-26
p97/VCP targets Toxoplasma gondii vacuoles for parasite restriction in interferon-stimulated human cells
Clough, B., Fisch, D., Mize, T. H., Encheva, V., Snijders, A., Frickel, E.
10.1101/2023.06.20.545566 — Posted: 2023-06-23
Abundant capped RNAs are derived from mRNA cleavage at 3'UTR G-Quadruplexes
Haberman, N., Digby, H., Faraway, R., Cheung, R., Jobbins, A. M., Parr, C., Yasuzawa, K., Kasukawa, T., Yip, C. W., Kato, M., Takahashi, H., Carninci, P., Vernia, S., Ule, J., Sibley, C. R., Martinez-Sanchez, A., Lenhard, B.
10.1101/2023.04.27.538568 — Posted: 2023-06-22
Wireless monitoring of respiration with EEG reveals relationships between respiration, behaviour and brain activity in freely moving mice
Dasgupta, D., Schneider-Luftman, D., Schaefer, A., Harris, J. J.
10.1101/2023.06.19.544346 — Posted: 2023-06-21
Dynamic X-chromosomal reactivation enhances female brain resilience
Kaeseberg, S., Bertin, M., Menon, R., Gabassi, E., Todorov, H., Frank, S., Brennenstuhl, H., Lohrer, B., Winter, J., Krummeich, J., Winkler, J., Winner, B., Weis, E., Hartwich, D., Diederich, S., Luck, K., Gerber, S., Lunt, P., Berninger, B., Falk, S., Schweiger, S., Karow, M.
10.1101/2023.06.17.545424 — Posted: 2023-06-21
The T766M-EGFR lung cancer mutation promotes tumor growth by exploiting newfound assembly mechanisms in ligand-free EGFR oligomers
Iyer, R. S., Needham, S. R., Galdadas, I., Davis, B. M., Roberts, S. K., Man, R. C., Zanetti-Domingues, L. C., Clarke, D. T., Fruhwirth, G. O., Parker, P. J., Rolfe, D. J., Gervasio, F. L., Martin-Fernandez, M. L.
10.1101/2023.06.16.545259 — Posted: 2023-06-20
Structure-guided design and optimization of covalent VHL-targeted sulfonyl fluoride PROTACs
Shah, R. R., De Vita, E., Conole, D., Sathyamurthi, P. S., Zhang, X., Fellows, E., Fleites, C. M., Queisser, M. A., Harling, J. D., Tate, E. W.
10.1101/2023.06.20.545773 — Posted: 2023-06-20
Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology
Castano, A., Silvestre, M., Wells, C. I., Sanderson, J. L., Ferrer, C. A., Ong, H. W., Lang, Y., Richardson, W., Silvaroli, J. A., Bashore, F. M., Smith, J. L., Genereux, I. M., Dempster, K., Drewry, D. H., Pabla, N. S., Bullock, A. N., Benke, T. A., Ultanir, S., Axtman, A. D.
10.1101/2023.04.24.538049 — Posted: 2023-06-16
Gastruloid-derived Primordial Germ Cell-like Cells (Gld-PGCLCs) develop dynamically within integrated tissues
Cooke, C. B., Barrington, C., Baillie-Benson, P., Nichols, J., Moris, N.
10.1101/2023.06.15.545059 — Posted: 2023-06-15

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