Channel: Fred Hutchinson Cancer Center

This collection includes bioRxiv and medRxiv papers from authors at Fred Hutchinson Cancer Center.

1413 Articles

The Immune Signatures Data Resource: A compendium of systems vaccinology datasets

Diray-Arce, J., Miller, H. E. R., Henrich, E., Gerritsen, B., Mule, M. P., Fourati, S., Gygi, J., Hagan, T., Tomalin, L., Rychov, D., Kazmin, D., Chawla, D. G., Meng, H., Dunn, P., Campbell, J., The Human Immunology Project Consortium (HIPC), , Sarwal, M., Tsang, J., Levy, O., Pulendran, B., Sekaly, R.-P., Floratos, A., Gottardo, R., Kleinstein, S., Suarez-Farinas, M.

10.1101/2021.11.05.465336 — Posted: 2021-11-08

A framework for detecting noncoding rare variant associations of large-scale whole-genome sequencing studies

Li, Z., Li, X., Zhou, H., Gaynor, S. M., Selvaraj, M. S., Arapoglou, T., Quick, C., Liu, Y., Chen, H., Sun, R., Dey, R., Arnett, D. K., Bielak, L. F., Bis, J. C., Blackwell, T., Blangero, J., Boerwinkle, E., Bowden, D. W., Brody, J. A., Cade, B. E., Conomos, M., Correa, A., Cupples, L. A., Curran, J. E., de Vries, P. S., Duggirala, R., Freedman, B. I., Goring, H. H. H., Guo, X., Kalyani, R. R., Kooperberg, C., Kral, B. G., Lange, L. A., Manichaikul, A. W., Martin, L. W., Mitchell, B. D., Montasser, M., Morrison, A., Naseri, T., O'Connell, J. R., Palmer, N. D., Peyser, P. A., Psaty, B. M., Raff

10.1101/2021.11.05.467531 — Posted: 2021-11-08

Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization

Young, W. J., Lahrouchi, N., Isaacs, A., Duong, T., Foco, L., Ahmed, F., Brody, J. A., Salman, R., Noordam, R., Benjamins, J.-W., Haessler, J., Lyytikäinen, L.-P., Repetto, L., Concas, M. P., van den Berg, M. E., Weiss, S., Baldassari, A. R., Bartz, T. M., Cook, J. P., Evans, D. S., Freudling, R., Hines, O., Isaksen, J. L., Lin, H., Mei, H., Moscati, A., Müller-Nurasyid, M., Nursyifa, C., Qian, Y., Richmond, A., Roselli, C., Ryan, K. A., Tarazona-Santos, E., Theriault, S., van Duijvenboden, S., Warren, H. R., Yao, J., Raza, D., Aeschbacher, S., Ahlberg, G., Alonso, A., Andreasen, L., Bis, J.

10.1101/2021.11.04.21265866 — Posted: 2021-11-04

Multilineage plasticity in prostate cancer through expansion of stem-like luminal epithelial cells with elevated inflammatory signaling

Zaidi, S., Zhao, J. L., Chan, J. M., Roudier, M. P., Wadosky, K. M., Gopalan, A., Karthaus, W. R., Choi, J., Lawrence, K., Chaudhary, O., Xu, T., Masilionis, I., Mazutis, L., Chaligne, R., Linkov, I., Barlas, A., Jungbluth, A., Rekhtman, N., Silber, J., Manova Todorova, K., Watson, P. A., True, L. D., Nelson, P. S., Scher, H. I., Rathkopf, D. E., Morris, M. J., Haffner, M. C., Goodrich, D. W., Pe'er, D., Sawyers, C. L.

10.1101/2021.11.01.466599 — Posted: 2021-11-03

Enrichment analyses identify shared associations for 25 quantitative traits in over 600,000 individuals from seven diverse ancestries

Smith, S. P., Shahamatdar, S., Cheng, W., Zhang, S., Paik, J., Graff, M., Haiman, C. A., Matise, T. C., North, K. E., Peters, U., Kenny, E., Gignoux, C. R., Wojcik, G. L., Crawford, L., Ramachandran, S.

10.1101/2021.04.20.440612 — Posted: 2021-11-03

Reversal of lineage plasticity in RB1/TP53-deleted prostate cancer through FGFR and Janus kinase inhibition

Karthaus, W., Chan, J., Setty, M., Love, J., Zaidi, S., Choo, Z.-N., Persad, S., LaClair, J., Lawrence, K., Chaudhary, O., Xu, T., Masilionis, I., Mazutis, L., Chaligne, R., Pe'er, D., Sawyers, C.

10.1101/2021.11.01.466615 — Posted: 2021-11-01

A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood

Kurniansyah, N., Goodman, M. O., Kelly, T., Elfassi, T., Wiggins, K., Bis, J., Guo, X. O., Palmas, W., Taylor, K. D., Lin, H., Haessler, J., Gao, Y., Shimbo, D., Smith, J. A., Yu, B., Feofanova, E., Smit, R., Wang, Z., Hwang, S.-J., Liu, S., Wassertheil-Smoller, S., Manson, J. E., Lloyd-Jones, D. M., Rich, S., Loos, R. J. F., Redline, S., Correa, A., Kooperberg, C., Fornage, M., Kaplan, R. C., Psaty, B. M., Rotter, J., Arnett, D., Morrison, A., Franceschini, N., Levy, D., the NHLBI Trans-Omics in Precision Medicine (TOPMed) Consortium, , Sofer, T.

10.1101/2021.10.31.21265717 — Posted: 2021-11-01

RNA-silencing induces target gene relocalization toward a specialized nuage domain

Mello, C., Yang, Y., Grunwald, D., Priess, J.

10.1101/2021.03.09.434681 — Posted: 2021-10-31

Adenovirus-α-defensin complexes induce NLRP3-associated maturation of human phagocytes via TLR4 engagement

Eichholz, K., Tran, H. T., Cheneau, C., Tran, T. T. P., Paris, O., Pugniere, M., Kremer, E. J.

10.1101/2021.10.26.465098 — Posted: 2021-10-26

Clinical performance characteristics of the Swift Normalase Amplicon Panel for sensitive recovery of SARS-CoV-2 genomes

Shrestha, L., Lin, M. J., Xie, H., Mills, M. G., Bakhash, S. A. M., Gaur, V. P., Livingston, R. J., Castor, J., Bruce, E. A., Botten, J. W., Huang, M.-L., Jerome, K. R., Greninger, A. L., Roychoudhury, P.

10.1101/2021.10.22.21265255 — Posted: 2021-10-26

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