Channel: Fred Hutchinson Cancer Center

This collection includes bioRxiv and medRxiv papers from authors at Fred Hutchinson Cancer Center.

1054 Articles

Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program

Robbins, H. A., Alcala, K., Khodayari Moez, E., Guida, F., Thomas, S., Zahed, H., Warkentin, M., Smith-Byrne, K., Brhane, Y., Muller, D., Albanes, D., Aldrich, M. C., Arslan, A. A., Bassett, J., Berg, C. D., Cai, Q., Chen, C., Davies, M. P., Diergaarde, B., Field, J. K., Freedman, N. D., Huang, W.-Y., Johansson, M., Jones, M., Koh, W.-P., Lam, S., Lan, Q., Langhammer, A., Liao, L. M., Liu, G., Malekzadeh, R., Milne, R. L., Montuenga, L. M., Rohan, T., Sesso, H. D., Severi, G., Sheikh, M., Sinha, R., Shu, X.-O., Stevens, V. L., Tammemägi, M. C., Tinker, L. F., Visvanathan, K., Wang, Y., Wang

10.1101/2022.03.21.22272544 — Posted: 2022-03-22

The SARS-CoV-2 Delta variant induces an antibody response largely focused on class 1 and 2 antibody epitopes

Greaney, A. J., Eguia, R. T., Starr, T. N., Khan, K., Franko, N., Logue, J. K., Lord, S. M., Speake, C., Chu, H. Y., Sigal, A., Bloom, J. D.

10.1101/2022.03.12.484088 — Posted: 2022-03-14

Mitochondrial Redox Adaptations Enable Aspartate Synthesis in SDH-deficient Cells

Hart, M. L., Quon, E., Vigil, A.-L. B. G., Engstrom, I. A., Newsom, O. J., Davidsen, K., Hoellerbauer, P., Carlisle, S. M., Sullivan, L. B.

10.1101/2022.03.14.484352 — Posted: 2022-03-14

The cancer chemotherapeutic 5-fluorouracil is a potent inhibitor of Fusobacterium nucleatum and its activity is modified by the intratumoral microbiota

LaCourse, K. D., Baryiames, A., Kempchinsky, A. G., Johnston, C. D., Bullman, S.

10.1101/2022.03.12.484096 — Posted: 2022-03-13

Assessment of Androgen Receptor splice variant-7 as a biomarker of clinical response in castration-sensitive prostate cancer

Sowalsky, A. G., Figueiredo, I., Lis, R. T., Coleman, I. G., Gurel, B., Bogdan, D., Yuan, W., Russo, J. W., Bright, J. R., Whitlock, N. C., Trostel, S. Y., Ku, A. T., Patel, R. A., True, L. D., Welti, J., Jimenez-Vacas, J. M., Rodridgues, D. N., Riisnaes, R., Neeb, A., Sprenger, C. T., Swain, A., Wilkinson, S., Karzai, F., Dahut, W. L., Balk, S. P., Corey, E., Nelson, P. S., Haffner, M. C., Plymate, S. R., de Bono, J. S., Sharp, A.

10.1101/2022.03.10.22271799 — Posted: 2022-03-12

Activation of targetable inflammatory immune signaling is seen in Myelodysplastic Syndromes with SF3B1 mutations

Choudhary, G., Pellagatti, A., Agianian, B., Smith, M., Bhagat, T. D., Gordon-Mitchell, S., Pandey, S., Shah, N., Aluri, S., Schwartz, L., Steeples, V., Booher, R., Ramachandra, M., Samson, M., Carbajal, M., Pradhan, K., Bowman, T., Pillai, M. M., Will, B., Wickrema, A., Shastri, A., Bradley, R. K., Martell, R. E., Steidl, U., Gavathiotis, E., Boultwood, J., Starczynowski, D. T., Verma, A.

10.1101/2022.03.09.483595 — Posted: 2022-03-09

Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors

THIBORD, F., Klarin, D., Brody, J. A., Chen, M.-H., Levin, M. G., Chasman, D. I., Goode, E. L., Hveem, K., Teder-Laving, M., Martinez-Perez, A., Aissi, D., Daian-Bacq, D., Ito, K., Natarajan, P., Lutsey, P. L., Nadkarni, G. N., Cuellar-Partida, G., Wolford, B. N., Pattee, J. W., Kooperberg, C., Braekkan, S. K., Li-Gao, R., Saut, N., Sept, C., Germain, M., Judy, R. L., Wiggins, K. L., Ko, D., O'Donnell, C., Taylor, K. D., Giulianini, F., De Andrade, M., Nost, T. H., Boland, A., Empana, J.-P., Koyama, S., Gilliland, T., Do, R., Wang, X., Zhou, W., Soria, J. M., Souto, J. C., Pankratz, N., Haessl

10.1101/2022.03.04.22271003 — Posted: 2022-03-08

Defining cellular population dynamics at single cell resolution during prostate cancer progression

Germanos, A. A., Arora, S., Zheng, Y., Goddard, E. T., Coleman, I. M., Ku, A. T., Wilkinson, S., Amezquita, R. A., Zager, M., Long, A., Yang, Y. C., Bielas, J. H., Gottardo, R., Ghajar, C. M., Nelson, P. S., Sowalsky, A. G., Setty, M., Hsieh, A. C.

10.1101/2022.03.02.482711 — Posted: 2022-03-04

Multi-ancestry meta-analysis identifies 2 novel loci associated with ischemic stroke and reveals heterogeneity of effects between sexes and ancestries

Surakka, I., Wu, K.-H. H., Hornsby, W. E., Wolford, B., Shen, F., Zhou, W., Huffman, J. E., Pandit, A., Hu, Y., Brumpton, B., Skogholt, A. H., Gabrielsen, M. E., Walters, R., The TOPMed Stroke Working Group, , Million Veteran Program (MVP), , Hveem, K., Kooperberg, C., Zollner, S., Wilson, P. W. F., Sutton, N. R., Daly, M., Neale, B., Willer, C. J., Global Biobank Meta-analysis Initiative (GBMI)

10.1101/2022.02.28.22271647 — Posted: 2022-03-01

Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution

Starr, T. N., Greaney, A. J., Hannon, W. W., Loes, A. N., Hauser, K., Dillen, J. R., Ferri, E., Ghez Farrell, A., Dadonaite, B., McCallum, M., Matreyek, K. A., Corti, D., Veesler, D., Snell, G., Bloom, J. D.

10.1101/2022.02.24.481899 — Posted: 2022-02-26

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