Channel: Fred Hutchinson Cancer Center

This collection includes bioRxiv and medRxiv papers from authors at Fred Hutchinson Cancer Center.

1203 Articles

Computationally restoring the potency of a clinical antibody against SARS-CoV-2 Omicron subvariants

Desautels, T. A., Arrildt, K. T., Zemla, A. T., Lau, E. Y., Zhu, F., Ricci, D., Cronin, S., Zost, S., Binshtein, E., Scheaffer, S. M., Dadonaite, B., Petersen, B. K., Engdahl, T. B., Chen, E., Handal, L. S., Hall, L., Goforth, J. W., Vashchenko, D., Nguyen, S., Weilhammer, D. R., Lo, J. K.-Y., Rubinfeld, B., Saada, E. A., Weisenberger, T., Lee, T.-H., Whitener, B., Case, J. B., Ladd, A., Silva, M. S., Haluska, R. M., Grzesiak, E. A., Earnhart, C. G., Hopkins, S. A., Bates, T. W., Thackray, L. B., Segelke, B. W., Lillo, A. M., Sundaram, S., Bloom, J. D., Diamond, M. S., Crowe, J. E., Carnahan

10.1101/2022.10.21.513237 — Posted: 2023-04-24

BayesDeBulk: A Flexible Bayesian Algorithm for the Deconvolution of Bulk Tumor Data

Petralia, F., Krek, A., Calinawan, A. P., Charytonowicz, D., Sebra, R., Feng, S., Gosline, S. J., Pugliese, P., Kennedy, J. J., Paulovich, A. G., Ceccarelli, M., Wang, P.

10.1101/2021.06.25.449763 — Posted: 2023-04-18

Adenovirus protein VII binds the A-box of HMGB1 to repress interferon responses.

Arnold, E. A., Kaai, R. J., Leung, K., Brinkley, M. R., Kelnhofer-Millevolte, L. E., Guo, M. S., Avgousti, D. C.

10.1101/2023.04.17.537247 — Posted: 2023-04-18

Estimating heritability explained by local ancestry and evaluating stratification bias in admixture mapping from summary statistics

Chan, T. F., Rui, X., Conti, D. V., Fornage, M., Graff, M., Haessler, J., Haiman, C., Highland, H. M., Jung, S. Y., Kenny, E., Kooperberg, C., Le Marchland, L., North, K. E., Tao, R., Wojcik, G., Gignoux, C. R., PAGE Consortium, , Chiang, C. W., Mancuso, N.

10.1101/2023.04.10.536252 — Posted: 2023-04-18

Hypercholesterolemia aggravates in-stent restenosis in rabbits: a mitigating effect of stent surface modification with CD47-derived peptide

Fishbein, I., Inamdar, V. V., Alferiev, I. S., Bratinov, G., Zviman, M. M., Yekhilevsky, A., Nagaswami, C., Gardiner, K. L., Levy, R. J., Stachelek, S. J.

10.1101/2023.02.27.530304 — Posted: 2023-04-15

Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations

Li, S., Wong, A., Sun, H., Bhatia, V., Javier, G., Jana, S., Mongomery, R. B., Wright, J. L., Lam, H.-M., Hsieh, A. C., Faltas, B. M., Haffner, M. C., Lee, J. K.

10.1101/2023.04.12.536652 — Posted: 2023-04-14

Carcinoma-associated fibroblast-like tumor cells remodel the Ewing sarcoma tumor microenvironment

Wrenn, E. D., Apfelbaum, A. A., Rudzinski, E. R., Deng, X., Jiang, W., Sud, S., Van Noord, R. A., Newman, E. A., Garcia, N. M., Hoglund, V. J., Bhise, S. S., Kanaan, S. B., Waltner, O. G., Furlan, S. N., Lawlor, E. R.

10.1101/2023.04.12.536619 — Posted: 2023-04-13

Single B cell transcriptomics identifies multiple isotypes of broadly neutralizing antibodies against flaviviruses

Lubow, J., Levoir, L. M., Ralph, D. K., Belmont, L., Contreras, M., Cartwright-Acar, C. H., Kikawa, C., Kannan, S., Davidson, E., Doranz, B. J., Duran, V., Sanchez, D. E., Sanz, A. M., Rosso, F., Einav, S., Matsen, F. A., Goo, L.

10.1101/2023.04.09.536175 — Posted: 2023-04-11

Microbiome Preterm Birth DREAM Challenge: Crowdsourcing Machine Learning Approaches to Advance Preterm Birth Research

Golob, J. L., Oskotsky, T. T., Tang, A., Roldan, A., Chung, V., Ha, C. W. Y., Wong, R., Flynn, K., Parraga-Leo, A., Wibrand, C., Minot, S. S., Andreoletti, G., Kosti, I., Bletz, J., Nelson, A., Gao, J., Wei, Z., Chen, G., Tang, Z.-Z., Novielli, P., Romano, D., Pantaleo, E., Amoroso, N., Monaco, A., Vacca, M., De Angelis, M., Bellotti, R., Tangaro, S., Kuntzleman, A., Bigcraft, I., Techtmann, S., Bae, D., Kim, E., Jeon, J., Joe, S., The Preterm Birth DREAM Community, , Theis, K., Ng, S. Q. Y., Lee, Y., Diaz-Gimeno, P., MacIntyre, D., Stolovitzky, G., Lynch, S. V., Albrecht, J., Romero, R., Ste

10.1101/2023.03.07.23286920 — Posted: 2023-04-11

Antibodies that neutralize all current SARS-CoV-2 variants of concern by conformational locking

Liu, L., Casner, R. G., Guo, Y., Wang, Q., Iketani, S., Chan, J. F.-W., Yu, J., Dadonaite, B., Nair, M. S., Mohri, H., Reddem, E. R., Yuan, S., Poon, V. K.-M., Chan, C. C.-S., Yuen, K.-Y., Sheng, Z., Huang, Y., Bloom, J. D., Shapiro, L., Ho, D. D.

10.1101/2023.04.08.536123 — Posted: 2023-04-10

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