Channel: Fred Hutchinson Cancer Center

This collection includes bioRxiv and medRxiv papers from authors at Fred Hutchinson Cancer Center.

1117 Articles

Expansion of human centromeric arrays in cells undergoing break-induced replication

Showman, S., Talbert, P. B., Xu, Y., Adeyemi, R. O., Henikoff, S.

10.1101/2023.11.11.566714 — Posted: 2023-11-15

Full-spike deep mutational scanning helps predict the evolutionary success of SARS-CoV-2 clades

Dadonaite, B., Brown, J., McMahon, T. E., Farrell, A. G., Asarnow, D., Stewart, C., Logue, J., Murrell, B., Chu, H. Y., Veesler, D., Bloom, J. D.

10.1101/2023.11.13.566961 — Posted: 2023-11-14

Mitochondrial diabetes in mice expressing a dominant-negative allele of nuclear respiratory factor-1 (NRF1) in pancreatic and β-cells

Morrish, F., Gingras, H., Noonan, J., Huang, L., Sweet, I. R., Kuok, I. T., Knoblaugh, S. E., Hockenbery, D. M.

10.1101/2023.01.22.524153 — Posted: 2023-11-13

Genome-Wide Interaction Analysis with DASH Diet Score Identified Novel Loci for Systolic Blood Pressure

Guirette, M., Lan, J., Mckeown, N. M., Brown, M. R., Chen, H., De Vries, P. S., Kim, H., Rebholz, C. M., Morrison, A. C., Bartz, T. M., Fretts, A., Guo, X., Lemaitre, R. N., Liu, C.-T., Noordam, R., de Mutsert, R., Rosendaal, F. R., Wang, C. A., Beilin, L. J., Mori, T. A., Oddy, W. H., Pennell, C. E., Chai, J.-F., Whitton, C., van Dam, R. M., Liu, J., Tai, E. S., Sim, X., Neuhouser, M. L., Kooperberg, C., Tinker, L. F., Franceschini, N., Huan, T., Winkler, T. W., Bentley, A. R., Gauderman, W. J., Heerkens, L., Tanaka, T., Van Rooij, J., Munroe, P. B., Warren, H. R., Voortman, T., Chen, H., Rao

10.1101/2023.11.10.23298402 — Posted: 2023-11-12

Covid19Vaxplorer: a free, online, user-friendly COVID-19 Vaccine Allocation Comparison Tool

Trejo, I., Hung, P.-Y., Matrajt, L.

10.1101/2023.06.15.23291472 — Posted: 2023-11-11

Concurrent RB1 loss and BRCA-deficiency predicts enhanced immunological response and long-term survival in tubo-ovarian high-grade serous carcinoma

Saner, F. A. M., Takahashi, K., Budden, T., Pandey, A., Ariyaratne, D., Zwimpfer, T., Meagher, N. S., Fereday, S., Twomey, L., Pishas, K. I., Hoang, T., Bolithon, A., Traficante, N., Alsop, K., Christie, E. L., Kang, E.-Y., Nelson, G. S., Ghatage, P., Lee, C.-H., Riggan, M. J., Alsop, J., Beckmann, M. W., Boros, J., Brand, A. H., Brooks-Wilson, A., Carney, M. E., Coulson, P., Courtney-Brooks, M., Cushing-Haugen, K. L., Cybulski, C., El-Bahrawy, M. A., Elishaev, E., Erber, R., Gayther, S. A., Gentry-Maharaj, A., Gilks, B., Harnett, P. R., Harris, H. R., Hartmann, A., Hein, A., Hendley, J., _Aus

10.1101/2023.11.09.23298321 — Posted: 2023-11-10

Identifying metabolic features of colorectal cancer liability using Mendelian randomization

Bull, C. J., Hazelwood, E., Bell, J. A., Tan, V. Y., Constantinescu, A.-E., Borges, M. C., Legge, D. N., Burrows, K., Huyghe, J. R., Brenner, H., Castellvi-Bel, S., Chan, A. T., Kweon, S.-S., Le Marchand, L., Li, L., Cheng, I., Pai, R. K., Figueiredo, J. C., Murphy, N., Gunter, M. J., Timpson, N. J., Vincent, E. E.

10.1101/2023.03.10.23287084 — Posted: 2023-11-09

A novel approach to exploring the dark genome and its application to mapping of the vertebrate virus 'fossil record'.

Blanco-Melo, D., Campbell, M. A., Zhu, H., Dennis, T., Mohda, S., Lytras, S., Hughes, J. J., Gatseva, A., Gifford, R. J.

10.1101/2023.10.17.562709 — Posted: 2023-11-06

Evolutionary origin and structural ligand mimicry by the inserted domain of alpha-integrin proteins

Hollis, J. A., Chan, M. C., Malik, H. S., Campbell, M. G.

10.1101/2023.11.05.565221 — Posted: 2023-11-06

A statistical framework for powerful multi-trait rare variant analysis in large-scale whole-genome sequencing studies

Li, X., Chen, H., Selvaraj, M. S., Van Buren, E., Zhou, H., Wang, Y., Sun, R., McCaw, Z. R., Yu, Z., Arnett, D. K., Bis, J. C., Blangero, J., Boerwinkle, E., Bowden, D. W., Brody, J. A., Cade, B. E., Carson, A. P., Carlson, J. C., Chami, N., Chen, Y.-D. I., Curran, J. E., de Vries, P. S., Fornage, M., Franceschini, N., Freedman, B. I., Gu, C., Heard-Costa, N. L., He, J., Hou, L., Hung, Y.-J., Irvin, M. R., Kaplan, R. C., Kardia, S. L. R., Kelly, T., Konigsberg, I., Kooperberg, C., Kral, B. G., Li, C., Loos, R. J. F., Mahaney, M. C., Martin, L. W., Mathias, R. A., Minster, R. L., Mitchell, B. D

10.1101/2023.10.30.564764 — Posted: 2023-11-02

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