COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

31,093 Articles (22,658 medRxiv, 8,435 bioRxiv)

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Increased mannosylation of extracellular vesicles in Long COVID plasma provides a potential therapeutic target for Galanthus nivalis agglutinin (GNA) affinity resin
Pesqueira Sanchez, M. A., de Necochea Campion, R., Dalhuisen, T., Fehrman, E. A., Chhabra, P. S., Kelly, J. D., Martin, J. N., Deeks, S. G., Henrich, T. J., Peluso, M. J., LaRosa, S. P.
10.1101/2025.11.21.689519 — Posted: 2025-11-21
Antigen-reactive CD4+ T cells after SARS-CoV-2 vaccination show divergent phenotypic states with or without restimulation bias
Kocher, K., Drost, F., Schuelein, C., Spriewald, B., Schubert, B., Schober, K.
10.1101/2025.11.19.688845 — Posted: 2025-11-21
Omicron evolution drives increased ciliated cell tropism and dysfunction in nasal epithelia.
Parry, R., Mostafavi, H., McCallum, G., Sng, J. D. J., Joensuu, M., Short, K. R., Slonchak, A., Khromykh, A.
10.1101/2025.11.19.689397 — Posted: 2025-11-20
Pathogenic IgG from long COVID patients with neurological sequelae triggers sensitive but not cognitive impairments upon transfer into mice
Mignolet, M., Deroux, C., Florkin, T., Bielarz, V., De Swert, K., Halloin, N., Sprimont, L., Ladang, A., George, F., Gilloteaux, J., Abeloos, L., Van Weyenbergh, J., Jamoulle, M., Diederich, C., Gillet, N. A., Bulpa, P., Nicaise, C.
10.1101/2025.11.20.689423 — Posted: 2025-11-20
Humoral immunity induced by LP.8.1 monovalent vaccines against a broad range of SARS-CoV-2 variants including XEC, NB.1.8.1, XFG, and BA.3.2
Kaku, Y., Fujiwara, M., Uriu, K., Yo, M. S., Kawakubo, S., Ito, J., Itoh, N., Uwamino, Y., Saito, F., Satoh, H., The Genotype to Phenotype Japan (G2P-Japan) Consortium, , Sato, K.
10.1101/2025.11.18.689152 — Posted: 2025-11-20
A SARS-CoV-2 entry inhibitor trimerizes to lock the spike protein in a closed conformation
Mou, H., Gao, B., Ye, G., Zhang, L., Saxena, D., Bu, F., Vishwakarma, J., Zhou, S., Bayona, C. R., Li, L., Getmanenko, Y., Bhandari, J., Bailey, C. C., Crynen, G. C., Kitzmiller, C. E., Li, H., Otsuka, Y., Wang, C., Batra, L., Weston, S., Frieman, M. B., Meyerholz, D. K., Scampavia, L., Spicer, T., Harris, R. S., Cameron, M., Bannister, T., Zheng, J., Farzan, M., Li, F., Choe, H.
10.1101/2025.11.19.689107 — Posted: 2025-11-20
Epistasis and background dependence in the evolution of Omicron variants of the SARS-CoV-2 Spike protein
Moulana, A., Dupic, T., Desai, M. M.
10.1101/2025.11.18.689118 — Posted: 2025-11-19
Dynamics of interactions between three major respiratory pathogens in reconstituted human epithelium
Gibeaud, A., Terra, C., Portier, E., Lukas, P., Le Gouellec, A., Guedj, J., Graw, F., Pizzorno, A., Terrier, O.
10.1101/2025.11.17.688795 — Posted: 2025-11-17
Evolutionary rewiring of host metabolism and interferon signalling by SARS-CoV-2 variants
Giotis, E. S., Somji, R.-A., Brown, J. C., Rowles-Khalid, S., Abdullahi, T. B., Luo, D., Barthel, N., Mulleder, M., Ralser, M. S., Barclay, W. S. S., Rallis, C.
10.1101/2025.11.15.688605 — Posted: 2025-11-17
Distinct Mechanisms for Inhibition of SARS-CoV-2 Main Protease: Dimerization Promoted by Peptidomimetic Inhibitors and Disrupted by Ebselen
Liu, C., Jia, Q., Zhao, C., Zhongping, Y.
10.1101/2025.11.16.688752 — Posted: 2025-11-17

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* The Clinical Trials and Epidemiology subject categories are now closed to new submissions following the completion of bioRxiv's clinical research pilot project and launch of the dedicated health sciences server medRxiv (submit.medrxiv.org). New papers that report results of Clinical Trials must now be submitted to medRxiv. Most new Epidemiology papers also should be submitted to medRxiv, but if a paper contains no health-related information, authors may choose to submit it to another bioRxiv subject category (e.g., Genetics or Microbiology).