COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

30,687 Articles (22,478 medRxiv, 8,209 bioRxiv)

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Single administration of mosaic-8b RBD-nanoparticle vaccine prepared with atomic layer deposition technology elicits broadly neutralizing anti-sarbecovirus responses
Cohen, A. A., Keeffe, J. A., Rorick, A. V., Rho, S., Fils, A.-C. P., Manasyan, L., Gao, H., Gnanapragasam, P. N. P., Funke, H. H., Randolph, T. W., Garcea, R. L., Bjorkman, P. J.
10.1101/2025.06.16.660007 — Posted: 2025-06-18
Poldip2 deficiency attenuates disease severity in a mouse model of COVID-19
Hu, R., Valdivia, A., White, T., Ju, W., Brockman, M. L., Zhang, Z., Qu, H., Gafford, G., Joseph, G., Burton, S., Bassit, L., Charles, T. P., Levit, R. D., Derdeyn, C. A., Griendling, K. K., Lassegue, B., Hernandes, M. S.
10.1101/2025.06.17.657579 — Posted: 2025-06-18
SARS-CoV-2 ORF8 sequence conservation and mutational analysis -- insight into the influence of dataset size on identifying top mutations
Kandwal, S., Cmelo, I., Fayne, D.
10.1101/2025.06.16.659836 — Posted: 2025-06-17
Open-science discovery of DNDI-6510, a compound that addresses genotoxic and metabolic liabilities of the COVID Moonshot SARS-CoV-2 Mpro lead inhibitor
Griffen, E. J., Fearon, D., McGovern, B. L., Koekemoer, L., Balcomb, B. H., Szommer, T., Fate, G., Robinson, R. P., Lefker, B. A., Duberstein, S., Lahav, N., Braillard, S., Vangeel, L., Laporte, M., Charvillon, F. B., MacLeod, A. K., Wells, A., Garner, P., Knight, R., Rees, P., Simon, A., Jochmans, D., Neyts, J., Read, K. D., Barr, H., Robinson, M., Lee, A. A., London, N., Chodera, J., von Delft, F., White, K. M., Perry, B., Sjo, P., von Delft, A. R.
10.1101/2025.06.16.660018 — Posted: 2025-06-17
Dual Role of Plasmacytoid Dendritic Cells in Humoral and CD8⁺ T Cell Memory Post COVID-19 mRNA Vaccination
Pizzichetti, C., Latino, I., Virgilio, T., Capucetti, A., Chahine, K., Cascione, L., Moro, S. G., Brugger, M., Kozarac, N., Pulfer, A., Renner, L., Thakur, R. S., Benarafa, C., Legler, D. F., Gonzalez, S. F.
10.1101/2025.06.13.659539 — Posted: 2025-06-16
Susceptible host dynamics explain pathogen resilience to perturbations
Park, S. W., Nielsen, B. F., Howerton, E., Grenfell, B., Cobey, S.
10.1101/2025.06.13.659551 — Posted: 2025-06-16
SARS-CoV-2 envelope protein induces LC3 lipidation via the V-ATPase-ATG16L1 axis
Figueras-Novoa, C., Timimi, L. J., Marcassa, E., Taveira-Marques, R., Adams, L., Jiang, M., Wu, M. Y., Montaner, B., Ng, K., De Lorenzo, G., Furnon, W., Cowton, V. M., Upfold, N., Kassiotis, G., Harvey, R., Patel, A. H., Howell, M., Ulferts, R., Beale, R.
10.1101/2025.06.12.659257 — Posted: 2025-06-13
Biophysics of the Coronavirus-Membrane Interaction: Role of Nonequilibrium Binding Energy
Udema, I. I.
10.1101/2025.06.10.658990 — Posted: 2025-06-12
Garlic-Derived Allicin Modulates Expression of the SARS-CoV-2 Spike Receptor-Binding Domain in Human Splenic Fibroblasts
Kaur, A., Assogba, B. D.
10.1101/2025.06.10.659002 — Posted: 2025-06-12
Reducing Supply Chain Dependencies for Viral Genomic Surveillance: Get by with a Little HELP from Commercial Enzymes already in your Lab Freezer
Kovalenko, G., Hosmillo, M., Kent, C., Rowe, K., Rambaut, A., Loman, N. J., Quick, J., Goodfellow, I.
10.1101/2025.06.11.658579 — Posted: 2025-06-12

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Subject Areas
* The Clinical Trials and Epidemiology subject categories are now closed to new submissions following the completion of bioRxiv's clinical research pilot project and launch of the dedicated health sciences server medRxiv (submit.medrxiv.org). New papers that report results of Clinical Trials must now be submitted to medRxiv. Most new Epidemiology papers also should be submitted to medRxiv, but if a paper contains no health-related information, authors may choose to submit it to another bioRxiv subject category (e.g., Genetics or Microbiology).