Channel:  Impact of Genomic Variation on Function (IGVF)

bioRxiv posts many COVID19-related papers. A reminder: they have not been formally peer-reviewed and should not guide health-related behavior or be reported in the press as conclusive.

106 Articles

A flexible modeling and inference framework for estimating variant effect sizes from GWAS summary statistics
Spence, J. P., Sinnott-Armstrong, N., Assimes, T., Pritchard, J. K.
10.1101/2022.04.18.488696 — Posted: 2022-04-19
Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence
Belk, J., Yao, W., Ly, N., Freitas, K., Chen, Y.-T., Shi, Q., Valencia, A., Shifrut, E., Kale, N., Yost, K., Duffy, C., Hwee, M., Miao, Z., Ashworth, A., Mackall, C., Marson, A., Carnevale, J., Vardhana, S., Satpathy, A.
10.1101/2022.04.20.488974 — Posted: 2022-04-21
Microbiota-instructed regulatory T cell differentiation is mediated by a distinct RORγt+ antigen presenting cell subset
Kedmi, R., Najar, T., Mesa, K. R., Grayson, A., Kroehling, L., Hao, Y., Hao, S., Pokrovskii, M., Xu, M., Talbot, J., Wang, J., Germino, J., Lareau, C. A., Satpathy, A. T., Anderson, M. S., Laufer, T. M., Aifantis, I., Bartleson, J. M., Allen, P. M., Paidassi, H., Gardner, J. M., Stoeckius, M., Littman, D. R.
10.1101/2021.11.19.469318 — Posted: 2022-04-29
Genome-wide CRISPR guide RNA design and specificity analysis with GuideScan2
Schmidt, H., Zhang, M., Mourelatos, H., Sanchez-Rivera, F. J., Lowe, S. W., Ventura, A., Leslie, C. S., Pritykin, Y.
10.1101/2022.05.02.490368 — Posted: 2022-05-03
A unique epigenomic landscape defines CD8+ tissue-resident memory T cells
Buquicchio, F. A., Fonseca, R., Belk, J. A., Evrard, M., Obers, A., Qi, Y., Daniel, B., Yost, K. E., Satpathy, A. T., Mackay, L. K.
10.1101/2022.05.04.490680 — Posted: 2022-05-06
A framework for summarizing chromatin state annotations within and identifying differential annotations across groups of samples
Vu, H. T., Koch, Z., Fiziev, P., Ernst, J.
10.1101/2022.05.08.491094 — Posted: 2022-05-08
Limited overlap of eQTLs and GWAS hits due to systematic differences in discovery
Mostafavi, H., Spence, J. P., Naqvi, S., Pritchard, J. K.
10.1101/2022.05.07.491045 — Posted: 2022-05-08
Deciphering the Impact of Genetic Variation on Human Polyadenylation
Linder, J., Kundaje, A., Seelig, G.
10.1101/2022.05.09.491198 — Posted: 2022-05-10
The dynseq genome browser track enables visualization of context-specific, dynamic DNA sequence features at single nucleotide resolution
Nair, S., Barrett, A., Li, D., Raney, B. J., Lee, B. T., Kerpedjiev, P., Ramalingam, V., Pampari, A., Lekschas, F., Wang, T., Haeussler, M., Kundaje, A.
10.1101/2022.05.26.493621 — Posted: 2022-05-31
CROP-Seq: a single-cell CRISPRi platform for characterizing candidate genes relevant to metabolic disorders in human adipocytes
Bielczyk-Maczynska, E., Sharma, D., Blencowe, M., Saliba-Gustafsson, P., Gloudemans, M. J., Yang, X., Carcamo-Orive, I., Wabitsch, M., Svensson, K. J., Park, C. Y., Quertermous, T., Knowles, J. W., Li, J.
10.1101/2022.06.27.497796 — Posted: 2022-06-27

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