Channel:  Harvard Program in Therapeutic Sciences

bioRxiv posts many COVID19-related papers. A reminder: they have not been formally peer-reviewed and should not guide health-related behavior or be reported in the press as conclusive.

114 Articles

Longitudinal and multimodal auditing of tumor adaptation to CDK4/6 inhibitors in HR+ metastatic breast cancers
Creason, A. L., Egger, J., Watson, C., Sivagnanam, S., Chin, K., MacPherson, K., Lin, J.-R., Chen, Y.-A., Johnson, B. E., Feiler, H. S., Galipeau, D., Navin, N. E., Demir, E., Chang, Y. H., Corless, C. L., Mitri, Z. I., Thomas, G., Sorger, P. K., Adey, A. C., Coussens, L. M., Gray, J. W., Mills, G. B., Goecks, J.
10.1101/2023.09.27.557464 — Posted: 2023-09-29
OpenFold: Retraining AlphaFold2 yields new insights into its learning mechanisms and capacity for generalization
Ahdritz, G., Bouatta, N., Floristean, C., Kadyan, S., Xia, Q., Gerecke, W., O'Donnell, T. J., Berenberg, D., Fisk, I., Zanichelli, N., Zhang, B., Nowaczynski, A., Wang, B., Stepniewska-Dziubinska, M. M., Zhang, S., Ojewole, A., Guney, M. E., Biderman, S., Watkins, A. M., Ra, S., Lorenzo, P. R., Nivon, L., Weitzner, B., Ban, Y.-E. A., Sorger, P. K., Mostaque, E., Zhang, Z., Bonneau, R., AlQuraishi, M.
10.1101/2022.11.20.517210 — Posted: 2023-08-12
Addressing persistent challenges in digital image analysis of cancerous tissues
Prabhakaran, S., Yapp, C., Baker, G. J., Beyer, J., Chang, Y. H., Creason, A. L., Krueger, R., Muhlich, J., Patterson, N. H., Sidak, K., Sudar, D., Taylor, A. J., Ternes, L., Troidl, J., Yubin, X., Sokolov, A., Tyson, D. R., Participants of the Cell Imaging Hackathon 2022
10.1101/2023.07.21.548450 — Posted: 2023-07-24
Immune Profiling of Dermatologic Adverse Events from Checkpoint Blockade using Tissue Cyclic Immunofluorescence
Maliga, Z., Kim, D. Y., Bui, A.-T. N., Lin, J.-R., Dewan, A. K., Murphy, G. F., Nirmal, A. J., Lian, C. G., Sorger, P. K., LeBoeuf, N. R.
10.1101/2023.04.03.535435 — Posted: 2023-04-05
Matrix and analysis metadata standards (MAMS) to facilitate harmonization and reproducibility of single-cell data
Wang, Y., Sarfraz, I., Teh, W. K., Sokolov, A., Herb, B. R., Creasy, H. H., Virshup, I., Dries, R., Degatano, K., Mahurkar, A., Schnell, D. J., Madrigal, P., Hilton, J., Gehlenborg, N., Tickle, T., Campbell, J. D.
10.1101/2023.03.06.531314 — Posted: 2023-03-07
Parallel evolution of mutational fitness effects over 50,000 generations
Limdi, A., Owen, S. V., Herren, C., Lenski, R. E., Baym, M.
10.1101/2022.05.17.492023 — Posted: 2023-03-07
Multi-modal digital pathology for colorectal cancer diagnosis by high-plex immunofluorescence imaging and traditional histology of the same tissue section
Lin, J.-R., Chen, Y.-A., Campton, D., Cooper, J., Coy, S., Yapp, C., Tefft, J., McCarty, E., Ligon, K., Rodig, S. J., Reese, S., George, T., Santagata, S., Sorger, P. K.
10.1101/2022.09.28.509927 — Posted: 2023-02-21
Nociceptor neuroimmune interactomes reveal cell type- and injury-specific inflammatory pain pathways
Jain, A., Gyori, B., Hakim, S., Bunga, S., Taub, D. G., Ruiz-Cantero, M. C., Tong-Li, C., Andrews, N., Sorger, P. K., Woolf, C. J.
10.1101/2023.02.01.526526 — Posted: 2023-02-03
A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments
Chidley, C., Darnell, A. M., Gaudio, B. L., Lien, E. C., Barbeau, A. M., Vander Heiden, M. G., Sorger, P. K.
10.1101/2023.01.26.525375 — Posted: 2023-01-26
3D multiplexed tissue imaging reconstruction and optimized region-of-interest (ROI) selection through deep learning model of channels embedding
Burlingame, E., Ternes, L., Lin, J.-R., Chen, Y.-A., Kim, E. N., Gray, J. W., Santagata, S., Sorger, P. K., Chang, Y. H.
10.1101/2022.12.09.519807 — Posted: 2022-12-12

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