Channel:  UK Biobank

170 Articles

Genome-wide polygenic score to identify a monogenic risk-equivalent for coronary disease
Khera, A. V., Chaffin, M., Aragam, K., Emdin, C. A., Klarin, D., Haas, M., Roselli, C., Natarajan, P., Kathiresan, S.
10.1101/218388 — Posted: 2017-11-15
Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function
Hagenaars, S., Radakovic, R., Crockford, C., Fawns-Ritchie, C., International FTD-Genomics Consortium, , Harris, S. E., Gale, C. R., Deary, I. J.
10.1101/219345 — Posted: 2017-11-14
Phenome-wide association studies (PheWAS) across large "real-world data" population cohorts support drug target validation
Diogo, D., Tian, C., Franklin, C., Alanne-Kinnunen, M., March, M., Spencer, C., Vangjeli, C., Weale, M., Mattsson, H., Kilpelainen, E., Sleiman, P., Reilly, D., McElwee, J., Maranville, J., Chatterjee, A., Bhandari, A., the 23andMe Research Team, , Reeve, M.-P., Hutz, J., Bing, N., John, S., MacArthur, D., Salomaa, V., Ripatti, S., Hakonarson, H., Daly, M., Palotie, A., Hinds, D., Donnelly, P., Fox, C., Day-Williams, A., Plenge, R., Runz, H.
10.1101/218875 — Posted: 2017-11-13
A genome-wide association study finds novel genetic associations with broadly-defined headache in UK Biobank (N = 223,773)
Meng, W., Adams, M., Hebert, H., Deary, I., McIntosh, A., Smith, B.
10.1101/217786 — Posted: 2017-11-10
Genome-wide association study of habitual physical activity in over 277,000 UK Biobank participants identifies multiple variants including CADM2 and APOE
Klimentidis, Y. C., Raichlen, D. A., Bea, J., Garcia, D. O., Mandarino, L. J., Alexander, G. E., Chen, Z., Going, S. B.
10.1101/179317 — Posted: 2017-11-07
Loss of function, missense, and intronic variants in NOTCH1 confer different risks for left ventricular outflow tract obstructive heart defects in two European cohorts
Helle, E., Cordova-Palomera, A., Ojala, T., Saha, P., Potiny, P., Gustafsson, S., Ingelsson, E., Bamshad, M., Nickerson, D., Chong, J. X., University of Washington Center for Mendelian Geno, , Ashley, E., Priest, J. R.
10.1101/215301 — Posted: 2017-11-07
A common allele in FGF21 associated with preference for sugar consumption lowers body fat in the lower body and increases blood pressure
Frayling, T. M., Beaumont, R., Jones, S. E., Yaghootkar, H., Tuke, M. A., Ruth, K. S., Casanova, F., West, B., Locke, J., Sharp, S., Jie, Y., Thompson, W. D., Harrison, J. W., Lindgren, C. M., Grarup, N., Murray, A., Freathy, R. M., Weedon, M. N., Tyrrell, J., Wood, A. R.
10.1101/214700 — Posted: 2017-11-06
Genome-wide analysis yields new loci associating with aortic valve stenosis
Helgadottir, A., Thorleifsson, G., Gretarsdottir, S., Stefansson, O. A., Tragante, V., Thorolfsdottir, R. B., Jonsdottir, I., Bjornsson, T., Steinthorsdottir, V., Verweij, N., Nielsen, J. B., Zhou, W., Folkersen, L., Martinsson, A., Heydarpour, M., Prakash, S., Oskarsson, G., Gudbjartsson, T., Geirsson, A., Olafsson, I., Sigurdsson, E. L., Almgren, P., Melander, O., Franco-Cereceda, A., Hamsten, A., Fritsche, L., Lin, M., Yang, B., Hornsby, W., Guo, D., Brummett, C. M., Abecasis, G., Mathis, M., Milewicz, D., Body, S. C., Eriksson, P., Willer, C. J., Hveem, K., Newton-Cheh, C., Smith, J. G., D
10.1101/213595 — Posted: 2017-11-03
Heritability of regional brain volumes in large-scale neuroimaging and genetic studies
Zhao, B., Ibrahim, J. G., Li, Y., Li, T., Wang, Y., Shan, Y., Zhu, Z., Zhou, F., Zhang, J., Huang, C., Liao, H., Yang, L., Thompson, P. M., Zhu, H.
10.1101/208496 — Posted: 2017-10-25
Birthweight, Type 2 Diabetes and Cardiovascular Disease: Addressing the Barker Hypothesis with Mendelian randomization
Zanetti, D., Tikkanen, E., Gustafsson, S., Priest, J. R., Burgess, S., Ingelsson, E.
10.1101/208629 — Posted: 2017-10-25

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