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368 Reviews — eLife — Biochemistry

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Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia.
Joseph, R. E., Wales, T. E., Jayne, S., Britton, R. G., Fulton, D. B., Engen, J. R., Dyer, M. J. S., Andreotti, A.
10.1101/2023.12.18.572223 — Posted: 2023-12-18 — Discussion: 2024-11-14  eLife
Malaria parasites require a divergent heme oxygenase for apicoplast gene expression and biogenesis
Blackwell, A. M., Jami-Alahmadi, Y., Nasamu, A. S., Kudo, S., Senoo, A., Slam, C., Tsumoto, K., Wohlschlegel, J. A., Caaveiro, J. M. M., Goldberg, D. E., Sigala, P. A.
10.1101/2024.05.30.596652 — Posted: 2024-05-31 — Discussion: 2024-11-13  eLife
A new class of receptors: Lipids regulate mammalian Gsalpha-stimulated adenylyl cyclase activities via their membrane anchors
Landau, M., Elsabbagh, S., Gross, H., Fuchs, A. C. D., Schultz, A., Schultz, J. E.
10.1101/2024.08.06.606792 — Posted: 2024-08-07 — Discussion: 2024-10-23  eLife
Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARgamma
Shang, J., Kojetin, D.
10.1101/2024.05.15.594037 — Posted: 2024-05-15 — Discussion: 2024-10-18  eLife
Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC)
Zhou, F., Zhang, Y., Zhu, Y., Zhou, Q., Shi, Y., Hu, Q.
10.1101/2024.04.30.591959 — Posted: 2024-05-02 — Discussion: 2024-10-10  eLife
A quantitative comparison of human embryonic and induced stem cell proteomes
Brenes, A. J., Griesser, E. J., Sinclair, L. V., Jiang, H., Yoshikawa, H., Davidson, L., Platani, M., Swedlow, J., Cantrell, D. A., Lamond, A. I.
10.1101/2021.10.20.464767 — Posted: 2021-10-20 — Discussion: 2024-10-08  eLife
Large-scale characterization of drug mechanism of action using proteome-wide thermal shift assays
Van Vranken, J. G., Li, J., Mintseris, J., Gadzuk-Shea, M., Gygi, S. P., Schweppe, D.
10.1101/2024.01.26.577428 — Posted: 2024-01-27 — Discussion: 2024-10-07  eLife
SUMO's intrinsically disordered N-terminus is an intramolecular inhibitor of SUMO - SIM interactions
Richter, S. M., Jin, F., Ritterhoff, T., Fergin, A., Maurer, E., Frank, A., Hajnal, A., Klevit, R. E., Gräter, F., Flotho, A., Melchior, F.
10.1101/2024.01.04.574143 — Posted: 2024-01-05 — Discussion: 2024-09-26  eLife
Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells
Zeng, S., Wang, Y., Ying, M., Jin, C., Ying, C., Wang, D., Wu, H., Hu, X.
10.1101/2024.06.26.600909 — Posted: 2024-06-27 — Discussion: 2024-09-26  eLife
ATP Prevents Aggregation of Protein via Modulating its Monomeric Conformation
Sarkar, S., Gupta, S., Mahato, C., Das, D., Mondal, J.
10.1101/2024.01.15.575740 — Posted: 2024-01-16 — Discussion: 2024-09-20  eLife

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