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222 Reviews — eLife — Genetics

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Massively Parallel Polyribosome Profiling Reveals Translation Defects of Human Disease-Relevant UTR Mutations
Li, W.-P., Su, J.-Y., Chang, Y.-C., Wang, Y.-L., Chiang, H.-L., Hsieh, Y.-T., Chiang, Y.-H., Ko, Y.-L., Chiang, B.-J., Yang, C.-H., Huang, Y.-T., Lin, C.-L.
10.1101/2024.04.11.589132 — Posted: 2024-04-13 — Discussion: 2025-09-15  eLife
Life-history trade-offs explain local adaptation in Arabidopsis thaliana
Brachi, B., Filiault, D., Pisupati, R., Dahan, T., Igolkina, A., Anastasio, A., Box, M. S., Duncan, S., Karasov, T., Kerdaffrec, E., Merwin, L., Morton, T., Nizhynska, V., Novikova, P. Y., Rabanal, F. A., Tsuchimatsu, T., Sall, T., Dean, C., Holm, S., Bergelson, J., Nordborg, M.
10.1101/2025.05.18.654693 — Posted: 2025-05-23 — Discussion: 2025-08-04  eLife
Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically-diverse Caenorhabditis nematodes
Banse, S. A., Sedore, C. A., Coleman-Hulbert, A., Johnson, E., Onken, B., Hall, D., Segerdell, E., Jackson, E. G., Song, Y., Osman, H. C., Xue, J., Basttistoni, E., Guo, S., Foulger, A., Achanta, M., Sheikh, M., Fitzgibbon, T., Willis, J. H., Woodruff, G. C., Driscoll, M., Lithgow, G., Phillips, P. C.
10.1101/2024.10.23.619838 — Posted: 2024-10-26 — Discussion: 2025-08-04  eLife
ZC3H11A mutations cause high myopia by triggering PI3K-AKT and NF-κB mediated inflammatory reactions in humans and mice
Chen, C., Liu, Q., Rong, Y., Tang, C., Zhao, X., Li, D., Lu, F., Qu, J., Liu, X.
10.1101/2023.08.29.555422 — Posted: 2023-08-30 — Discussion: 2025-07-21  eLife
A zebrafish system for identifying genetic dependencies in melanocytes and melanoma
Perlee, S., Ma, Y., Hunter, M. V., Swanson, J. B., Ming, Z., Xia, J., Lionnet, T., McGrail, M., White, R.
10.1101/2024.03.22.586101 — Posted: 2024-03-23 — Discussion: 2025-07-09  eLife
Female-germline specific protein Sakura interacts with Otu and is crucial for germline stem cell renewal and differentiation and oogenesis
Azlan, A., Zhu, L., Fukunaga, R.
10.1101/2024.10.04.616675 — Posted: 2024-10-04 — Discussion: 2025-07-02  eLife
WRN and WRNIP1 ATPases impose high fidelity on translesion synthesis by Y-family DNA polymerases
Yoon, J. H., Sellamuthu, K., Pakash, L., Prakash, S.
10.1101/2025.04.02.646818 — Posted: 2025-04-07 — Discussion: 2025-06-27  eLife
A whole organism map of X-inactivation reveals tissue-specific escape as an exceptionally rare event in humans
Gylemo, B., Nestor, C. E.
10.1101/2023.06.26.546519 — Posted: 2023-06-27 — Discussion: 2025-06-11  eLife
The robust, high-throughput, and temporally regulated roxCre and loxCre reporting systems for genetic modifications in vivo
Shi, M., Li, J., Liu, X., Liu, K., Pu, W., Weng, W., Zhang, S., Zhao, H., Lui, K., Zhou, B.
10.1101/2024.04.23.590680 — Posted: 2024-04-23 — Discussion: 2025-05-09  eLife
Impaired central pattern generators due to abnormal EPHA4 signaling leads to idiopathic scoliosis
Wang, L., Zhao, S., Yang, X., Zheng, P., Wen, W., Xu, K., Cheng, X., Li, Q., Khanshour, A. M., Koike, Y., Liu, J., Fan, X., Otomo, N., Chen, Z., Li, Y., Li, L., Xie, H., Zhu, P., Li, X., Niu, Y., Wang, S., Liu, S., Yuan, S., Terao, C., Li, Z., Chen, S., Zhao, X., Liu, P., Posey, J. E., Wu, Z., Qiu, G., Ikegawa, S., Lupski, J., Rios, J. J., Wise, C. A., Zhang, J., Zhao, C., Wu, N.
10.1101/2024.03.04.583361 — Posted: 2024-03-10 — Discussion: 2025-04-29  eLife

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