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525 Reviews — All Partners — Biochemistry

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Towards a unified molecular mechanism for ligand-dependent activation of NR4A-RXR heterodimers
Yu, X., He, Y., Kamenecka, T. M., Kojetin, D. J.
10.1101/2025.03.19.642122 — Posted: 2025-03-19 — Discussion: 2025-05-22  eLife
Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IkappaBalpha without requiring ATP
Polley, S., Borar, P., Biswas, T., Huxford, T., Ghosh, G.
10.1101/2023.06.27.546692 — Posted: 2023-06-27 — Discussion: 2025-05-21  eLife
The late onset Alzheimer's disease risk factor iRhom2/RHBDF2 is a modifier of microglial TREM2 proteolysis
Jocher, G., Lichtenthaler, S. F., Müller, S. A., Hsia, H.-E., Lastra-Osua, M., Özcelik, G., Hofmann, L. I., Assfalg, M., Dinkel, L., Schlepckow, K., Willem, M., Haass, C., Tahirovic, S., Blobel, C. P., Feng, X.
10.1101/2024.09.13.612888 — Posted: 2024-09-16 — Discussion: 2025-05-20  EMBO Press
Surprising variety in the USP deubiquitinase catalytic mechanism
Keijzer, N., Priyanka, A., Stijf-Bultsma, Y., Fish, A., Gersch, M., Sixma, T. K.
10.1101/2023.07.24.550302 — Posted: 2023-07-24 — Discussion: 2025-05-20  EMBO Press
Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein
Shinkai, Y., Ding, Y., Matsui, T., Devitt, G., Akiyama, M., Shen, T.-L., Nishida, M., Ida, T., Akaike, T., Mahajan, S., Fukuto, J. M., Shigeta, Y., Kumagai, Y.
10.1101/2023.10.19.563042 — Posted: 2023-10-19 — Discussion: 2025-05-14  eLife
Epitope Sequence and Modification Fingerprints of Anti-Aβ Antibodies
Talucci, I., Leske, T., Klafki, H.-W., Hassan, M. M., Steiert, A., Morgado, B., Bothe, S., van Werven, L., Liepold, T., Walter, J., Schindelin, H., Wiltfang, J., Wirths, O., Jahn, O., Maric, H. M.
10.1101/2025.02.26.640323 — Posted: 2025-03-03 — Discussion: 2025-05-09  eLife
Targeted Protein Degradation by KLHDC2 Ligands Identified by High Throughput Screening
Zhou, H., Zhou, T., Yu, W., Liu, L., Ko, Y., Johnson, K. A., Wilson, I. A., Schultz, P. G., Bollong, M. J.
10.1101/2025.03.31.646306 — Posted: 2025-04-01 — Discussion: 2025-05-09  eLife
The alternative oxidase reconfigures the larval mitochondrial electron transport system to accelerate growth and development in Drosophila melanogaster
Garcia, G. S., Othonicar, M. F., Campos, A. T. P., Kilbourn, E. A., Bicego, K. C., Lerchner, J., Tennessen, J. M., Oliveira, M. T.
10.1101/2025.02.20.639223 — Posted: 2025-02-23 — Discussion: 2025-05-09  eLife
Shifting the PPARγ conformational ensemble towards a transcriptionally repressive state improves covalent inhibitor efficacy
Arifova, L., MacTavish, B. S., Laughlin, Z., Karadi Girdhar, M. N., Shang, J., Li, M.-H., Yu, X., Zhu, D., Kamenecka, T. M., Kojetin, D.
10.1101/2025.03.04.640448 — Posted: 2025-03-05 — Discussion: 2025-05-08  eLife
Identification of the Regulatory Elements and Protein Substrates of Lysine Acetoacetylation
Fu, Q., Nguyen, T., Kumar, B., Azadi, P., Zheng, Y. G.
10.1101/2024.10.31.621296 — Posted: 2024-10-31 — Discussion: 2025-04-22  eLife

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