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370 Reviews — eLife — Biochemistry

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An SNP variant MT1-MMP with a defect in its collagenolytic activity confers the fibrotic phenotype of Dupuytren's Disease
Itoh, Y., Ng, M., Wiberg, A., Inoue, K., Hirata, N., Paiva, K. B., Ito, N., Dzobo, K., Sato, N., Gifford, V., Fijita, Y., Inada, M., Furniss, D.
10.1101/2020.06.09.142513 — Posted: 2020-06-12 — Discussion: 2020-09-16  eLife
Conservation of function with diversification of higher-order structure within sensor histidine kinases
Igor Dikiy, Danielle Swingle, Kaitlyn Toy, Uthama R Edupuganti, Giomar Rivera-Cancel, Kevin H Gardner
10.1101/2020.07.08.194225 — Posted: 2020-07-10 — Discussion: 2020-09-16  eLife
More than just a ticket canceller: The mitochondrial processing peptidase matures complex precursor proteins at internal cleavage sites
Friedl, J., Knopp, M. R., Groh, C., Paz, E., Gould, S. B., Boos, F., Herrmann, J. M.
10.1101/2020.07.02.183996 — Posted: 2020-07-03 — Discussion: 2020-09-08  eLife
The crystal structure of the Ca2+-ATPase 1 from Listeria monocytogenes reveals a pump primed for dephosphorylation
Basse Hansen, S., Dyla, M., Neumann, C. M. T., Lauwring Andersen, J., Kjaergaard, M., Nissen, P.
10.1101/2020.06.23.166462 — Posted: 2020-06-23 — Discussion: 2020-09-01  eLife
The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans
Al Rifai, O., Julien, C., Faubert, D., Lira-Navarrete, E., Narimatsu, Y., Lacombe, J., Clausen, H., Ferron, M.
10.1101/2020.07.16.206656 — Posted: 2020-07-16 — Discussion: 2020-08-24  eLife
Optogenetic activation of heterotrimeric Gi proteins by LOV2GIVe - a rationally engineered modular protein
Garcia-Marcos, M., Parag-Sharma, K., Marivin, A., Maziarz, M., Luebbers, A., Nguyen, L. T.
10.1101/2020.08.17.253781 — Posted: 2020-08-19 — Discussion: 2020-08-20  eLife
Exosite inhibition of A Disintegrin And Metalloproteinase with Thrombospondin motif (ADAMTS)-5 by a glycoconjugated arylsulfonamide
Santamaria, S., Cuffaro, D., Nuti, E., Ciccone, L., Tuccinardi, T., Liva, F., D'Andrea, F., de Groot, R., Rossello, A., Ahnstroem, J.
10.1101/2020.06.12.146324 — Posted: 2020-06-12 — Discussion: 2020-07-24  eLife
A giant leap in sequence space reveals the intracellular complexities of evolving a new function
Hall, K. R., Robins, K. J., Rich, M. H., Calcott, M. J., Copp, J., Williams, E. M., Little, R. F., Schwörer, R., Evans, G. B., Patrick, W. M., Ackerley, D. F.
10.1101/2020.05.27.118489 — Posted: 2020-05-30 — Discussion: 2020-07-20  eLife
TAZ inhibits GR and coordinates hepatic glucose homeostasis in normal physiologic states
Xu, S., Liu, Y., Hu, R., Wang, M., Stohr, O., Xiong, Y., Chen, L., Kang, H., Zheng, L., Cai, S., He, L., Wang, C., Copps, K. D., White, M., Miao, J.
10.1101/2020.05.12.091264 — Posted: 2020-05-14 — Discussion: 2020-05-15  eLife

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