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370 Reviews — eLife — Biochemistry

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Dystroglycan N-terminal domain enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy
Okuma, H., Hord, J. M., Chandel, I., Anderson, M. E., Venzke, D., Walimbe, A. S., Joseph, S., Gastel, Z., Hara, Y., Saito, F., Matsumura, K., Campbell, K. P.
10.1101/2022.08.09.502851 — Posted: 2022-08-09 — Discussion: 2022-10-13  eLife
The conserved centrosomal motif, γTuNA, forms a dimer that directly activates microtubule nucleation by the γ-tubulin ring complex (γTuRC).
Rale, M. J., Romer, B., Mahon, B. P., Travis, S. M., Petry, S.
10.1101/2022.04.11.487887 — Posted: 2022-04-11 — Discussion: 2022-10-12  eLife
Structural basis of Yta7 ATPase-mediated nucleosome disassembly
Wang, F., Feng, X., He, Q., Li, H., Li, H.
10.1101/2022.05.13.491901 — Posted: 2022-05-13 — Discussion: 2022-10-04  eLife
Didemnin B and ternatin-4 inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes
Juette, M. F., Carelli, J. D., Rundlet, E. J., Brown, A., Shao, S., Ferguson, A., Wasserman, M. R., Holm, M., Taunton, J., Blanchard, S. C.
10.1101/2022.08.01.502281 — Posted: 2022-08-01 — Discussion: 2022-10-04  eLife
A novel fold for acyltransferase-3 (AT3) proteins provides a framework for transmembrane acyl-group transfer
Newman, K. E., Tindall, S. N., Mader, S. L., Khalid, S., Thomas, G. H., Van der Woude, M. W.
10.1101/2022.06.30.498268 — Posted: 2022-06-30 — Discussion: 2022-09-23  eLife
A Feed-forward Pathway Drives LRRK2 kinaseMembrane Recruitment and Apparent Activation
Vides, E. G., Adhikari, A., Lis, P., Purlyte, E., Shumate, J. L., Lasso, E. S., Dhekne, H. S., Alessi, D. R., Pfeffer, S. R.
10.1101/2022.04.25.489459 — Posted: 2022-04-25 — Discussion: 2022-09-22  eLife
Hepatic AMPK activation in response to dynamic REDOX balance is a biomarker of exercise to improve blood glucose control
Wu, M., Zhao, A., Yan, X., Gao, H., Zhang, C., Liu, X., Luo, Q., Xie, F., Liu, S., Shi, D.
10.1101/2022.05.15.491995 — Posted: 2022-05-15 — Discussion: 2022-09-16  eLife
Deep mutational scanning and machine learning reveal structural and molecular rules governing allosteric hotspots in homologous proteins
Leander, M., Liu, Z., Cui, Q., Raman, S.
10.1101/2022.05.01.490188 — Posted: 2022-05-01 — Discussion: 2022-09-02  eLife
DNA passes through cohesin's hinge as well as its Smc3-kleisin interface
Nasmyth, K. A., Collier, J. E.
10.1101/2022.05.30.494034 — Posted: 2022-05-30 — Discussion: 2022-08-27  eLife
Ligand-induced shifts in conformational ensembles that predict transcriptional activation
Khan, S. H., Braet, S. M., Koehler, S. J., Elacqua, E., Anand, G. S., Okafor, C. D.
10.1101/2022.05.29.493907 — Posted: 2022-05-29 — Discussion: 2022-08-27  eLife

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