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381 Reviews — eLife — Biochemistry

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Distinct mechanisms of inhibition of Kv2 potassium channels by tetraethylammonium and RY785
Zhang, S., Stix, R., Orabi, E. A., Bernhardt, N., Faraldo-Gomez, J. D.
10.1101/2024.07.25.605170 — Posted: 2024-07-25 — Discussion: 2026-04-08  eLife
Cryo-EM structure of the bicarbonate receptor GPR30
Kaneda, S., Jo-Watanabe, A., Akasaka, H., Oshima, H. S., Yokomizo, T., Shihoya, W., Nureki, O.
10.1101/2024.05.19.594840 — Posted: 2024-05-19 — Discussion: 2026-04-08  eLife
Membrane curvature regulates Ups1 dependent phosphatidic acid transfer across lipid bilayers
Sadeqi, F., Dong, D., Stroh, K., Vache, M., Metz, J., Riedel, D., Janshoff, A., Risselada, H. J., Kolenda, C., Meinecke, M.
10.1101/2025.04.03.647039 — Posted: 2025-04-04 — Discussion: 2026-03-27  eLife
In vitro reconstitutions suggest a general model for paradoxical activation of ARAF, BRAF, and CRAF by diverse RAF inhibitor types that does not rely on negative allostery.
Tkacik, E., Jang, D. M., Boxer, K., Ha, B. H., Eck, M. J.
10.64898/2025.12.15.694443 — Posted: 2025-12-17 — Discussion: 2026-03-23  eLife
A Structural Code for Assembly Specificity in GID/CTLH-Type E3 Ligases
van gen Hassend, P. M., Schindelin, H.
10.64898/2025.12.09.693151 — Posted: 2025-12-10 — Discussion: 2026-03-20  eLife
Molecular mechanism for cargo-mediated initiation of kinesin-1 activation
Shukla, S., Cross, J. A., Kish, M., Yadav, S. K., Weijman, J. F., O'Regan, L., Mantell, J., Borucu, U., Leng, X., Schaffitzel, C., Phillips, J. J., Woolfson, D. N., Dodding, M. P.
10.1101/2025.04.08.647705 — Posted: 2025-04-08 — Discussion: 2026-03-16  eLife
Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells
Zeng, S., Wang, Y., Ying, M., Jin, C., Ying, C., Wang, D., Wu, H., Hu, X.
10.1101/2024.06.26.600909 — Posted: 2024-06-27 — Discussion: 2026-03-12  eLife
Interaction hierarchy among Cdv proteins drives recruitment to membrane necks
De Franceschi, N., Blanch-Jover, A., Dekker, C.
10.1101/2024.10.03.616404 — Posted: 2024-10-03 — Discussion: 2026-03-11  eLife
Rescuing the Function of Missense-Mutated Tumor Suppressor VHL using Stabilizing Small Molecules
Karanicolas, J.
10.64898/2026.01.02.697373 — Posted: 2026-01-02 — Discussion: 2026-03-11  eLife
Structural elucidation of the hexameric MmpS4-MmpL4 complex from Mycobacterium tuberculosis
Earp, J. C., Lichti, N. P., Garaeva, A., Meikle, V., Niederweis, M., Seeger, M. A.
10.64898/2026.01.07.698164 — Posted: 2026-01-08 — Discussion: 2026-03-05  eLife

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