Channel:  Francis Crick Institute

bioRxiv posts many COVID19-related papers. A reminder: they have not been formally peer-reviewed and should not guide health-related behavior or be reported in the press as conclusive.

1024 Articles

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp13 Helicase
Beale, R., Bertolin, A. P., Borg, A., Canal, B., Diffley, J. F., Drury, L. S., Harvey, R., Howell, M., Hussain, S., Kjaer, S., McCauley, J., McCoy, L., Milligan, J., Posse, V., Roustan, C., Ulferts, R., Weissmann, F., Wu, M., Zeng, J.
10.1101/2021.04.07.438808 — Posted: 2021-04-08
Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp15 Endoribonuclease
Beale, R., Bertolin, A. P., Canal, B., Deegan, T. D., Diffley, J. F., Drury, L. S., Fujisawa, R., Howell, M., Labib, K., McClure, A. W., Ulferts, R., Weissmann, F., Wu, M., Zeng, J.
10.1101/2021.04.07.438811 — Posted: 2021-04-08
Oncogenic RAS activity predicts response to chemotherapy and outcome in lung adenocarcinoma
East, P., Kelly, G., Biswas, D., Marani, M., Hancock, D. C., Creasy, T., Sachsenmeier, K., Swanton, C., de Carne Trecesson, S., Downward, J.
10.1101/2021.04.02.437896 — Posted: 2021-04-04
Common ALS/FTD risk variants in UNC13A exacerbate its cryptic splicing and loss upon TDP-43 mislocalization
Brown, A.-L., Wilkins, O. G., Keuss, M. J., Hill, S. E., Zanovello, M., Lee, W. C., Lee, F. C. Y., Masino, L., Qi, Y. A., Bryce-Smith, S., Bampton, A., Gatt, A., Phatnani, H., NYGC ALS Consortium, , Schiavo, G., Fisher, E. M. C., Raj, T., Secrier, M., Lashley, T., Ule, J., Buratti, E., Humphrey, J., Ward, M. E., Fratta, P.
10.1101/2021.04.02.438170 — Posted: 2021-04-04
Biallelic mutations in cancer genomes reveal local mutational determinants
Demeulemeester, J., Dentro, S. C., Gerstung, M., Van Loo, P.
10.1101/2021.03.29.437407 — Posted: 2021-03-30
Severity of SARS-CoV-2 infection as a function of the interferon landscape across the respiratory tract of COVID-19 patients.
Sposito, B., Broggi, A., Pandolfi, L., Crotta, S., Ferrarese, R., Sisti, S., Clementi, N., Ambrosi, A., Liu, E., Frangipane, V., Saracino, L., Marongiu, L., Facchini, F., Bottazzi, A., Fossali, T., Colombo, R., Clementi, M., Tagliabue, E., Pontiroli, A., Meloni, F., Wack, A., Mancini, N., Zanoni, I.
10.1101/2021.03.30.437173 — Posted: 2021-03-30
In vitro teratogenicity testing using a 3D, embryo-like gastruloid system
Mantziou, V., Baillie-Benson, P., Jaklin, M., Kustermann, S., Martinez Arias, A., Moris, N.
10.1101/2021.03.30.437698 — Posted: 2021-03-30
N-myristoyltransferase inhibition is synthetic lethal in MYC-deregulated cancers
Lueg, G. A., Faronato, M., Gorelik, A., Goya Grocin, A., Caamano-Gutierrez, E., Falciani, F., Solari, R., Carr, R., Bell, A. S., Bartlett, E., Hutton, J. A., Llorian-Sopena, M., Chakravarty, P., Brzezicha, B., Janz, M., Garnett, M. J., Calado, D. P., Tate, E. W.
10.1101/2021.03.20.436222 — Posted: 2021-03-20
HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration
Guedan, A., Donaldson, C. D., Cosnefroy, O., Taylor, I. A., Bishop, K. N.
10.1101/2021.03.18.436028 — Posted: 2021-03-18
Synchrony between daily rhythms of malaria parasites and hosts is driven by an essential amino acid
Prior, K. F., Middleton, B., Owolabi, A. T., Westwood, M. L., Holland, J., O'Donnell, A. J., Blackman, M. J., Skene, D. J., Reece, S. E.
10.1101/2020.08.24.264689 — Posted: 2021-03-17

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