bioRxiv is receiving many new papers on coronavirus SARS-CoV-2.   A reminder: these are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information.

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Hepatocyte Circadian Clocks Control Cholesterol Metabolism and Protect From Metabolic Dysfunction-Associated Steatohepatitis (MASH)
de Assis, L. V. M., Jegodzinski, L., Inderhees, J., Wowro, S., Marques Affonso, J., Heyde, I., Fischer, E. L., von Schoenfels, W., Schenk, A., Rossner, F., Schupp, M., Marquardt, J. U., Demir, M., Oster, H.
10.1101/2025.08.07.669039 — Posted: 2025-08-10 — Discussion: 2025-12-19  PREreview
Development of Loop Mediated Isothermal Amplification for Rapid and Sensitive Detection of Enteroaggregative Escherichia coli (EAEC).
Amare Amdiyee, A., Sisay Tessema, T.
10.1101/2025.11.04.686462 — Posted: 2025-11-05 — Discussion: 2025-12-19  PREreview
Shaker it OFF: Biophysical Characterization of an Inactivating Potassium Conductance Mediating Object Segmentation in a Collision-Detecting Neuron
Shaulsky, G. H., Bellini, D., Ulloa, D., Nasiotis, E., Khan, H., Luo, J., Wang, H., Dierick, H., Zong, C., Gabbiani, F. H., Dewell, R. B.
10.1101/2025.09.04.674057 — Posted: 2025-09-09 — Discussion: 2025-12-18  PREreview
Developing an Early Diagnostic Signature and Deciphering the Microbial-Host Dynamics in Lower Respiratory Tract Infection (LRTI) in Paediatric Intensive Care Unit (PICU) Patients
Wu, Z., Youssef, G., Kean, I., Zhang, Z., Clark, J. A., Pathan, N., Han, N.
10.1101/2025.10.31.25335414 — Posted: 2025-11-06 — Discussion: 2025-12-18  PREreview
Geno-pheno characterization of crop rhizospheres: An integrated Raman spectroscopy and microbiome approach in conventional and organic agriculture
Son, Y., He, P., Baldwin, M., Li, G., Wang, Z., Gu, A., Kao-Kniffin, J.
10.1101/2025.06.10.658954 — Posted: 2025-06-17 — Discussion: 2025-12-17  Arcadia Science
Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8+ T cells underlies distinct functional potential
Park, S. L., Painter, M. M., Manne, S., Alcalde, V., McLaughlin, M., Sullivan, M. A., Mathew, D., Torres, L., Huang, Y. J., Reeg, D. B., Douek, N. R., Campos, T., Klapholz, M., Cardenas, M. A., Fang, V., Ngiow, S. F., KC, W., Goel, R. R., Baxter, A. E., Wu, J. E., Tan, M., Berry, C. T., Ellebrecht, C. T., Huang, A. C., Papazian, E., Liu, Y., Rajasekaran, K., Brody, R. M., Thaler, E. R., Basu, D., Diab, A., Giles, J. R., Wherry, E. J.
10.1101/2025.08.08.669213 — Posted: 2025-08-11 — Discussion: 2025-12-17  PREreview
Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer knock-in mouse phenotypes
Nicholson, L., Tang, S. J., Karra, T., Abouletta, H., Strittmatter, S. M.
10.1101/2025.09.05.674487 — Posted: 2025-09-11 — Discussion: 2025-12-17  PREreview
Inflammatory reprogramming of human brain endothelial cells compromises blood-brain barrier integrity in Alzheimer's disease
Pinals, R. L., Islam, M. R., King, O., Choi, A., Kang, E., Nakano, M., Tuyeras, A., Naomi, M. T., Ngo, A. P., Jiang, A., Truong, N., Agbas, E., Lozano Cruz, C. F., Staab, C., Ko, T., Bennett, D. A., Stanton, A. E., Langer, R., Tsai, L.-H.
10.1101/2025.09.26.678918 — Posted: 2025-09-28 — Discussion: 2025-12-17  PREreview
Structural constraints acting on the SARS-CoV-2 spike protein reveal limited space for viral adaptation
Herzig, J. C., Magwira, M. L., Lovell, S. C.
10.1101/2025.10.27.684767 — Posted: 2025-10-27 — Discussion: 2025-12-17  PREreview
Evaluation of the Clinical Performance of Two New Onchocerciasis Rapid Diagnostic Tests
de Souza, D. K., Ashong, Y., Afatodzie, S., Dogbe, M., Nyarko, A. A., Logonia, B., Frempong, K., Moore, C., Hundley, L., Kutjok, P., Prince-Guerra, J., Elder, S. E., Won, K. Y., Vedrine, C., Leissner, P., Duvoix, A., Adams, E., Biamonte, M., Boakye, D. A.
10.1101/2025.09.24.25336608 — Posted: 2025-09-30 — Discussion: 2025-12-17  PREreview

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