bioRxiv is receiving many new papers on coronavirus SARS-CoV-2.   A reminder: these are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information.

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Semaglutide drives weight loss through cAMP-dependent mechanisms in GLP1R-expressing hindbrain neurons
Gao, C., Geneve, I. C., Li, C., McElhern, K., Reitman, M., Lutas, A., Krashes, M. J.
10.1101/2025.08.12.668772 — Posted: 2025-08-15 — Discussion: 2025-12-11  PREreview
Central Amygdala Neuronal Ensembles Coordinate Visceral Pain and Its Affective Behaviors
Samineni, V. K., Sackey, J. N., Li, J.-N., Yang, L., Chamessian, A., Sewell, S. B., Hahm, H. J., Zhang, Y., Zhang, B., Gereau, R. W.
10.1101/2025.07.21.666026 — Posted: 2025-07-25 — Discussion: 2025-12-10  PREreview
Reprogrammed SimCells for Antimicrobial Therapy
Dong, Y., Ji, X., Dong, T., Wang, Y., Bakkeren, E., Foster, K. R., Huang, W. E.
10.1101/2025.11.15.688600 — Posted: 2025-11-15 — Discussion: 2025-12-10  PREreview
RamanOmics Decodes Spatial Vibrational-Molecular Architecture and Rewiring in Aging and Repair
Zhang, K., Chen, X., Monticolo, F., Sorrentino, S., Huang, H., Callahan, C., Qiao, Y., Zhou, J., Brodowska, S., Sapantzi, S., Qi, J., Wu, Y., Dang, T. N. S., Viggiani, F., Ho, C.-K., Xu, Y., J. Kobayashi-Kirschvink, K., Mung, T., Phatnani, H., Dou, Z., Kang, J. W., So, P. T. C., Shu, J.
10.64898/2025.12.04.692337 — Posted: 2025-12-08 — Discussion: 2025-12-10  Arcadia Science
Machine Learning Analysis of Post-Acute COVID Symptoms Identifies Distinct Clusters and Severity Groups
Peng, B., Zhang, Y., Dalhuisen, T., Rogers, A., Estevez, J., Davies, H. E., Jones, S. J., Capric, V., Haddad, N. S., Miners, K. L., Ladell, K., Martin, J. N., Kelly, J. D., Deeks, S. G., Peluso, M. J., Putrino, D., Price, D. A., Dupont, C. L., Freire, M., VanElzakker, M. B., Proal, A., Scheuermann, R. H., Lee, F. E.-H., Tan, G. S., Qian, Y.
10.1101/2025.11.16.25340350 — Posted: 2025-11-17 — Discussion: 2025-12-10  PREreview
Enhancer-driven random gene overexpression (ERGO): a method to study gene function in Chlamydomonas
Lihanova, Y., Craig, R. J., Pribbernow, M., Goss, R., Sasso, S.
10.1101/2025.09.05.674469 — Posted: 2025-09-07 — Discussion: 2025-12-09  Arcadia Science
Scalable transcription factor mapping uncovers the regulatory dynamics of natural and synthetic transcription factors in human T cell states
Mullins, R. D., Zaretsky, J., Stoller, E., Moore, M., Takacsi-Nagy, O., Shpynov, O., Sampaleanu, R., Roth, T. L., Satpathy, A. T., Mitra, R. D., Puram, S. V.
10.1101/2025.10.09.681414 — Posted: 2025-10-10 — Discussion: 2025-12-09  preLights
Time-resolved phylogenomics analysis reveals patterns in biosphere nutrient limitation through Earth history
Ni, Z., Osborn, T., Zhong, J., Gonzalez, A., Puzella, W., Klos, A., Le, B., Leonetti, A., Boden, J. S., Stueeken, E. E., Anderson, R. E.
10.1101/2025.11.13.688358 — Posted: 2025-11-14 — Discussion: 2025-12-09  Arcadia Science
Raman2RNA: Live-cell label-free prediction of single-cell RNA expression profiles by Raman microscopy
Kobayashi-Kirschvink, K. J., Gaddam, S., James-Sorenson, T., Grody, E., Ounadjela, J. R., Ge, B., Zhang, K., Kang, J. W., Xavier, R., So, P. T. C., Biancalani, T., Shu, J., Regev, A.
10.1101/2021.11.30.470655 — Posted: 2021-12-01 — Discussion: 2025-12-08  Arcadia Science
Hematopoietic stem cell gene therapy improves outcomes in a clinically relevant mousemodel of Multiple Sulfatase Deficiency
Pham, V., Tricoli, L., Hong, X., Wongkittichote, P., Castruccio Castracani, C., Guerra, A., Schlotawa, L., Adang, L. A., Kuhs, A., Cassidy, M. M., Kane, O., Tsai, E., Presa, M., Lutz, C. M., Rivella, S. B., Ahrens-Nicklas, R. C.
10.1101/2024.03.08.584099 — Posted: 2024-03-12 — Discussion: 2025-12-08  Arcadia Science

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