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DeepDOX1: A Dual-Drive Framework Integrating Deep Learning and First-Principles Physics for Drug-Protein Affinity Prediction
Liu, Z., Sun, H., Wang, Y., Ren, Y., Rao, L., Huang, Z., Cao, H., Hu, X., Zhu, X., Li, M., Wan, J.
10.64898/2025.12.12.693818 — Posted: 2025-12-15 — Discussion: 2026-03-11  PREreview
A thirty-year trend of increasing clinical orientation at the National Institutes of Health
Busse, B. L., Tucker, J. M., Allen, S. E., Santangelo, G. M., Willis, K. A.
10.64898/2025.12.16.694423 — Posted: 2025-12-19 — Discussion: 2026-03-11  preLights
RAG-ESM: Improving pretrained protein language models via sequence retrieval
Sgarbossa, D., Bitbol, A.-F.
10.1101/2025.04.02.646805 — Posted: 2025-04-08 — Discussion: 2026-03-10  Arcadia Science
Evolutionary remodeling of non-canonical ORF translation in mammals
Chang, Y., Lei, T., Zhou, F., Jiang, J., Huang, Y., Zhu, Z., Zhang, H.
10.1101/2025.09.16.676541 — Posted: 2025-09-17 — Discussion: 2026-03-10  Arcadia Science
A Unified Multi-modal LLM for Dynamic Protein-Ligand Interactions and Generative Molecular Design
Jing, H., Miao, Y.
10.64898/2025.12.01.691647 — Posted: 2025-12-03 — Discussion: 2026-03-10  Arcadia Science
ESMDisPred: A Structure-Aware CNN-Transformer Architecture for Intrinsically Disordered Protein Prediction
Kabir, M. W. U., Dey, A., Nafees, F., Hoque, M. T.
10.64898/2026.01.22.701204 — Posted: 2026-01-24 — Discussion: 2026-03-10  Arcadia Science
High-resolution characterization of nasal microbial dynamics in young children
Hoving, D., Steenbergen, R. A. M., Singh, Y., El Safadi, D., German, E. L., Barros de Campos, I., Fourie, E., van Roermund, M., de Kroon, A. C., van der Valk, I., Bogaert, D., Wessels, E., de Vries, J. J. C., Miellet, W. R., Trzczinski, K., Ferreira, D. M., van Houten, M. A., Jochems, S. P.
10.1101/2025.08.22.25334231 — Posted: 2025-08-26 — Discussion: 2026-03-10  Rapid Reviews Infectious Diseases
Fluorescence Lifetime Unmixing: A New Workflow for FLIM Live-Cell Imaging
Wetzker, C., Zoccoler, M. L., Iarovenko, S., Okafornta, C. W., Nobst, A., Hartmann, H., Mueller-Reichert, T., Haase, R., Fabig, G.
10.1101/2025.03.05.641717 — Posted: 2025-03-06 — Discussion: 2026-03-09  Arcadia Science
Chemogenetic Manipulation of the Subthalamic Nucleus-Substantia Nigra Pars Reticulata Pathway Promotes Recovery in HemiParkinsonian Rat Models
Stegamat, N., Smit, R., Rajavong, J., Campion, T. J., Pinjala, S. M., Smith, G. M.
10.1101/2025.08.28.672861 — Posted: 2025-09-03 — Discussion: 2026-03-09  PREreview
Exopolysaccharides of Lactobacillus crispatus mediate key balancing interactions with the vaginal mucosa
Croatti, V., Dricot, C., Eilers, T., Dillen, J., Van Riallaer, T., Cauwenberghs, E., Van Tente, I., Bakelants, S., Vandenheuvel, D., Allonsius, C. N., Pintelon, I., Thys, S., Mensah, W., Naldi, M., Bron, P., Wittouck, S., Spacova, I., Parolin, C., Vitali, B., Lebeer, S.
10.64898/2026.02.05.703754 — Posted: 2026-02-05 — Discussion: 2026-03-09  Arcadia Science

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