bioRxiv/medRxiv TRiP Review Activity

46 Reviews — All Partners — Pharmacology and Toxicology

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Predicting drug polypharmacology from cell morphology readouts using variational autoencoder latent space arithmetic
Chow, Y. L., Singh, S., Carpenter, A. E., Way, G. P.
10.1101/2021.09.02.458673 — Posted: 2021-09-03 — Discussion: 2021-11-01  Review Commons
Bisphosphonate drugs have actions outside the skeleton and inhibit the mevalonate pathway in alveolar macrophages
Rogers, M. J., Munoz, M. A., Fletcher, E. K., Skinner, O. P., Jurczyluk, J., Kristianto, E., Hodson, M., Sun, S., Ebetino, F. H., Croucher, D. R., Hansbro, P. M., Center, J. R.
10.1101/2021.08.09.455652 — Posted: 2021-08-10 — Discussion: 2021-11-01  eLife
Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity
Babolmorad, G., Latif, A., Pollock, N. M., Domingo, I. K., Delyea, C., Rieger, A. M., Allison, W. T., Bhavsar, A. P.
10.1101/2020.06.19.162057 — Posted: 2020-06-20 — Discussion: 2021-04-07  EMBO Press
Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin
Lomas, D., Irving, J. A., Arico-Muendel, C., Belyanskaya, S., Brewster, A., Brown, M. J. B., Chung, C.-w., Dave, H., Denis, A., Dodic, N., Dossang, A., Eddershaw, P., Klimaszewska, D., Haq, I., Holmes, D., Hutchinson, J., Jagger, A. M., Jakhria, T., Jigorel, E., Liddle, J., Lind, K., Marciniak, S. J., Messer, J., Neu, M., Olszewski, A., Ordonez, A., Ronzoni, R., Rowedder, J., Rüdiger, M., Skinner, S., Smith, K., Terry, R., Trottet, L., Uings, I., Wilson, S., Zhu, Z., Pearce, A. C.
10.1101/2020.07.26.217661 — Posted: 2020-07-28 — Discussion: 2021-04-02  EMBO Press
PLZF is a new substrate of CRBN with thalidomide and 5-hydroxythalidomide
Yamanaka, S., Murai, H., Saito, D., Abe, G., Tokunaga, E., Iwasaki, T., Takahashi, H., Takeda, H., Suzuki, T., Shibata, N., Tamura, K., Sawasaki, T.
10.1101/2020.02.28.969071 — Posted: 2020-02-28 — Discussion: 2021-04-02  EMBO Press
Database for drug metabolism and comparisons, NICEdrug.ch, aids discovery and design
MohammadiPeyhani, H., Chiappino-Pepe, A., Haddadi, K., Hafner, J., Hadadi, N., Hatzimanikatis, V.
10.1101/2020.05.28.120782 — Posted: 2020-05-30 — Discussion: 2021-03-24  eLife

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