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415 Reviews — eLife — Immunology

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Ex vivo and in vivo CRISPR/Cas9 screenings identify the roles of protein N-glycosylation in regulating T-cell activation and functions
Hong, Y., Si, X., Liu, W., Mai, X., Zhang, Y.
10.1101/2025.08.20.671236 — Posted: 2025-08-24 — Discussion: 2026-03-02  eLife
Synaptotagmin 1 and Synaptotagmin 7 promote MR1-mediated presentation of Mycobacterium tuberculosis antigens
Kim, S.-J., Peterson, J. C., Olive, A. J., Tafesse, F. G., Kulicke, C. A., Karamooz, E., Lewinsohn, D. M.
10.1101/2025.06.23.660389 — Posted: 2025-06-26 — Discussion: 2026-03-02  eLife
Protein supersaturation powers innate immune signaling
Rodriguez Gama, A., Miller, T., Lange, J. J., Wu, J., Song, X., Venkatesan, S., Unruh, J., Bradford, W., Halfmann, R.
10.1101/2023.03.20.533581 — Posted: 2023-03-21 — Discussion: 2026-02-26  eLife
Cribriform Plate Microenvironment Assembles a Suppressive Myeloid Network during EAE-induced Neuroinflammation
Laaker, C., Hsu, M., Madrid, A., Port, J., Vrba, S. M., Herbath, M., Baenen, C., Kumar, M., Priyathilaka, T. T., Sandor, M., Fabry, Z.
10.64898/2026.01.07.698165 — Posted: 2026-01-08 — Discussion: 2026-02-25  eLife
The 1000+ mouse project: large-scale spatiotemporal parametrization and modeling of preclinical cancer immunotherapies
Kenet, A. L., Achar, S., Dwivedi, A., Buckley, J., Pouzolles, M., Qin, H., Chien, C., Taylor, N., Altan-Bonnet, G. Y.
10.1101/2025.03.17.643712 — Posted: 2025-03-20 — Discussion: 2026-02-12  eLife
TGF-β drives the conversion of conventional NK cells into uterine tissue-resident NK cells to support murine pregnancy
Barahona, J. D., Yang, L., Nelson, D. M., Yokoyama, W. M.
10.1101/2025.11.18.688992 — Posted: 2025-11-18 — Discussion: 2026-02-11  eLife
Tolerance to Lung Infection in TWIK2 K+ Efflux Mediated Macrophage Trained Immunity
Thompson, J., Li, Y., Song, Y., Kim, K.-W., Malik, A., Xu, J.
10.1101/2025.05.25.655979 — Posted: 2025-05-28 — Discussion: 2026-02-11  eLife
Predestined neutrophil heterogeneity in homeostasis varies in transcriptional and phenotypic response to Candida
Scherer, A. K., Hopke, A., Xu, S., Viens, A., Alexander, N. J., Timmer, K. D., Archambault, D., Floyd, D., Atallah, N. J., Rhee, C., Cetinbas, M., Scadden, D., Irimia, D., Sykes, D. B., Sadreyev, R. I., Mansour, M. K.
10.1101/2022.11.01.514676 — Posted: 2022-11-01 — Discussion: 2026-02-11  eLife
Endothelial TLR4 signaling drives tissue inflammation, Claudin-5 internalization, and vascular barrier breakdown in a mouse model of neonatal meningitis
Seegren, P. V., Rattner, A., Smallwood, P. M., Nathans, J.
10.64898/2025.12.31.697193 — Posted: 2026-01-12 — Discussion: 2026-02-11  eLife
Cas9+ conditionally immortalized neutrophil progenitors as a tool for genome wide CRISPR screening for neutrophil differentiation and function
Jong, R. M., Ching, K., Garelis, N. E., Zilinskas, A., Nguyenla, X., Rawal, S., Hill, B., Luckie, B., Shallow, L., Cox, J. S., Barton, G., Stanley, S.
10.1101/2022.07.19.500665 — Posted: 2022-07-20 — Discussion: 2026-02-11  eLife

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