bioRxiv/medRxiv TRiP Review Activity

45 Reviews — All Partners — Pharmacology and Toxicology

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Selectivity Landscape of 100 Therapeutically Relevant GPCR Profiled by an Effector Translocation-Based BRET Platform
Avet, C., Mancini, A., Breton, B., Le Gouill, C., Hauser, A. S., Normand, C., Kobayashi, H., Gross, F., Hogue, M., Lukasheva, V., Morissette, S., Fauman, E., Fortin, J.-P., Schann, S., Leroy, X., Gloriam, D. E., Bouvier, M.
10.1101/2020.04.20.052027 — Posted: 2020-04-24 — Discussion: 2022-02-23  eLife
GPCR-G protein selectivity - a unified meta-analysis
Hauser, A. S., Avet, C., Normand, C., Manchini, A., Inoue, A., Bouvier, M., Gloriam, D.
10.1101/2021.09.07.459250 — Posted: 2021-09-08 — Discussion: 2022-02-22  eLife
NBI-921352, a First-in-Class, Na V 1.6 Selective, Sodium Channel Inhibitor That Prevents Seizures in Scn8a Gain-of- Function Mice, and Wild-Type Mice and Rats
Johnson, J., Focken, T., Khakh, K., Tari, P. K., Dube, C., Williams, A., Andrez, J.-C., Bankar, G., Bogucki, D., Burford, K., Chang, E., Chowdhury, S., Dean, R., de Boer, G., Decker, S., Dehnhardt, C., Feng, M., Gong, W., Goodchild, S. J., Grimwood, M., Hasan, A., Hussainkhel, A., Jia, Q., Lee, S., Li, J., Lin, S., Lindgren, A., Lofstrand, V., Mezeyova, J., Namdari, R., Nelkenbrecher, K., Shuart, N. G., Sojo, L., Sun, S., Taron, M., Waldbrook, M., Weeratunge, D., Wesolowski, S., Wilson, M., Xie, Z., Yoo, R., Young, C., Zenova, A., Zhang, W., Cutts, A. J., Sherrington, R. P., Pimstone, S. N., W
10.1101/2021.08.29.458125 — Posted: 2021-08-31 — Discussion: 2022-01-24  eLife
Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy
Chen, L., You, Q., Liu, M., Li, S., Wu, Z., Hu, J., Xia, L., Zhang, S.
10.1101/2021.11.17.468949 — Posted: 2021-11-19 — Discussion: 2022-01-21  eLife
Fluorescence Activation Mechanism and Imaging of Drug Permeation with New Sensors for Smoking-Cessation Ligands
Nichols, A. L., Blumenfeld, Z., Fan, C., Luebbert, L., Blom, A. E. M., Cohen, B. N., Marvin, J. S., Borden, P. M., Kim, C., Muthusamy, A. K., Shivange, A. V., Knox, H. J., Campello, H. R., Wang, J. H., Dougherty, D. A., Looger, L., Gallagher, T., Rees, D. C., Lester, H. A.
10.1101/2021.10.04.463082 — Posted: 2021-10-04 — Discussion: 2021-12-23  eLife
{micro}-Theraphotoxin-Pn3a inhibition of Cav3.3 channels reveals a novel isoform-selective drug binding site
McArthur, J. R., Wen, J., Hung, A., Finol-Urdaneta, R. K., Adams, D. J.
10.1101/2021.10.04.463006 — Posted: 2021-10-04 — Discussion: 2021-11-15  eLife
Characterization of the Endogenous DAF-12 Ligand and Its Use as an Anthelmintic Agent in Strongyloides stercoralis
Wang, Z., Cheong, M. C., Tsien, J., Deng, H., Qin, T., Stoltzfus, J. D. C., Jaleta, T. G., Li, X., Lok, J. B., Kliewer, S. A., Mangelsdorf, D. J.
10.1101/2021.09.07.459359 — Posted: 2021-09-08 — Discussion: 2021-11-12  eLife
Covalent inhibition of endoplasmic reticulum chaperone GRP78 disconnects the transduction of ER stress signals to inflammation and lipid accumulation in diet-induced obese mice
Rong, J., Luo, D., Fan, N., Zhang, X., Ngo, F. Y., Zhao, J., Zhao, W., Huang, M., Li, D., Wang, Y.
10.1101/2021.08.20.457085 — Posted: 2021-08-20 — Discussion: 2021-11-10  eLife
Chemogenetic analysis of how receptors for short chain fatty acids regulate the gut-brain axis
Tobin, A. B., Barki, N., Bolognini, D., Borjesson, U., Jenkins, L., Riddell, J., Hughes, D. I., Ulven, T., Hudson, B. D., Ulven, E. R., Dekker, N., Milligan, G.
10.1101/2020.01.11.902726 — Posted: 2020-01-13 — Discussion: 2021-11-04  eLife
Predicting drug polypharmacology from cell morphology readouts using variational autoencoder latent space arithmetic
Chow, Y. L., Singh, S., Carpenter, A. E., Way, G. P.
10.1101/2021.09.02.458673 — Posted: 2021-09-03 — Discussion: 2021-11-01  Review Commons

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