bioRxiv/medRxiv TRiP Review Activity

50 Reviews — All Partners — Pharmacology and Toxicology

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Metformin protects trabecular meshwork against oxidative injury via activating integrin/ROCK signals
Xu, L., Zhang, X., Zhao, Y., Cao, Y., Liang, Y.
10.1101/2022.06.30.498232 — Posted: 2022-07-03 — Discussion: 2022-11-01  eLife
Mechanism of hyperproteinemia-induced blood cell homeostasis imbalance in an animal model
Wang, G., Wang, Y., Li, J., Peng, R., Liang, X., Chen, X., Jiang, G., Shi, J., Si-ma, Y., Xu, S.
10.1101/2021.08.09.455622 — Posted: 2021-08-10 — Discussion: 2022-07-16  eLife
Robust and Efficient Assessment of Potency (REAP): A Quantitative Tool for Dose-response Curve Estimation
Zhou, S., Liu, X., Fang, X., Chinchilli, V. M., Wang, M., Wang, H.-G., Dokholyan, N. V., Shen, C., Lee, J. J.
10.1101/2021.11.20.469388 — Posted: 2021-11-22 — Discussion: 2022-06-13  eLife
Modeling osteoporosis to design and optimize pharmacologic therapies comprising multiple drug types
Jörg, D. J., Fuertinger, D. H., Cherif, A., Bushinsky, D. A., Mermelstein, A., Raimann, J. G., Kotanko, P.
10.1101/2021.12.17.473190 — Posted: 2021-12-20 — Discussion: 2022-05-19  eLife
A Single Multipurpose FSH-Blocking Therapeutic for Osteoporosis and Obesity
Gera, S., Kuo, T.-C., Korkmaz, F., Sant, D., DeMambro, V., Gumerova, A. A., Sudha, K., Padilla, A., Prevot, G., Munitz, J., Teunissen, A., van Leent, M. M. T., Post, T. G. J. M., Fernandes, J. C., Netto, J., Sultana, F., Shelly, E., Kumar, P., Cullen, L., Chatterjee, J., Miyashita, S., Kannangara, H., Bhongade, M., Ievleva, K., Muradova, V., Batista, R., Robinson, C., Macdonald, A., Babunovic, S., Saxena, M., Meseck, M., Caminis, J., Iqbal, J., New, M. I., Ryu, V., Kim, S.-M., Cao, J., Zaidi, N., Fayad, Z. A., Lizneva, D., J. Rosen, C., Yuen, T., Zaidi, M.
10.1101/2022.02.28.482279 — Posted: 2022-03-02 — Discussion: 2022-04-29  eLife
Selectivity Landscape of 100 Therapeutically Relevant GPCR Profiled by an Effector Translocation-Based BRET Platform
Avet, C., Mancini, A., Breton, B., Le Gouill, C., Hauser, A. S., Normand, C., Kobayashi, H., Gross, F., Hogue, M., Lukasheva, V., Morissette, S., Fauman, E., Fortin, J.-P., Schann, S., Leroy, X., Gloriam, D. E., Bouvier, M.
10.1101/2020.04.20.052027 — Posted: 2020-04-24 — Discussion: 2022-02-23  eLife
GPCR-G protein selectivity - a unified meta-analysis
Hauser, A. S., Avet, C., Normand, C., Manchini, A., Inoue, A., Bouvier, M., Gloriam, D.
10.1101/2021.09.07.459250 — Posted: 2021-09-08 — Discussion: 2022-02-22  eLife
NBI-921352, a First-in-Class, Na V 1.6 Selective, Sodium Channel Inhibitor That Prevents Seizures in Scn8a Gain-of- Function Mice, and Wild-Type Mice and Rats
Johnson, J., Focken, T., Khakh, K., Tari, P. K., Dube, C., Williams, A., Andrez, J.-C., Bankar, G., Bogucki, D., Burford, K., Chang, E., Chowdhury, S., Dean, R., de Boer, G., Decker, S., Dehnhardt, C., Feng, M., Gong, W., Goodchild, S. J., Grimwood, M., Hasan, A., Hussainkhel, A., Jia, Q., Lee, S., Li, J., Lin, S., Lindgren, A., Lofstrand, V., Mezeyova, J., Namdari, R., Nelkenbrecher, K., Shuart, N. G., Sojo, L., Sun, S., Taron, M., Waldbrook, M., Weeratunge, D., Wesolowski, S., Wilson, M., Xie, Z., Yoo, R., Young, C., Zenova, A., Zhang, W., Cutts, A. J., Sherrington, R. P., Pimstone, S. N., W
10.1101/2021.08.29.458125 — Posted: 2021-08-31 — Discussion: 2022-01-24  eLife
Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy
Chen, L., You, Q., Liu, M., Li, S., Wu, Z., Hu, J., Xia, L., Zhang, S.
10.1101/2021.11.17.468949 — Posted: 2021-11-19 — Discussion: 2022-01-21  eLife
Fluorescence Activation Mechanism and Imaging of Drug Permeation with New Sensors for Smoking-Cessation Ligands
Nichols, A. L., Blumenfeld, Z., Fan, C., Luebbert, L., Blom, A. E. M., Cohen, B. N., Marvin, J. S., Borden, P. M., Kim, C., Muthusamy, A. K., Shivange, A. V., Knox, H. J., Campello, H. R., Wang, J. H., Dougherty, D. A., Looger, L., Gallagher, T., Rees, D. C., Lester, H. A.
10.1101/2021.10.04.463082 — Posted: 2021-10-04 — Discussion: 2021-12-23  eLife

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