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428 Reviews — All Partners — Cancer Biology

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Cancer missense mutations in the BRC repeats of BRCA2 protein disrupt RAD51 binding and activity leading to chemotherapeutic sensitivity
Jimenez-Sainz, J., Mathew, J., Garbarino, J., Eder, J. P., Jensen, R. B.
10.1101/2021.09.24.461749 — Posted: 2021-09-25 — Discussion: 2022-09-09  eLife
Covalent Disruptor of YAP-TEAD Association Suppresses Defective Hippo Signaling
Fan, M., Lu, W., Che, J., Kwiatkowski, N. P., Gao, Y., Seo, H.-S., Ficarro, S. B., Gokhale, P. C., Liu, Y., Geffken, E. A., Lakhani, J., Song, K., Kuljanin, M., Ji, W., Jiang, J., He, Z., Tse, J., Boghossian, A. S., Rees, M. G., Ronan, M. M., Roth, J. A., Mancias, J. D., Marto, J. A., Dhe-Paganon, S., Zhang, T., Gray, N.
10.1101/2022.05.10.491316 — Posted: 2022-05-11 — Discussion: 2022-09-09  eLife
Revised International Staging System (R-ISS) stage-dependent analysis uncovers oncogenes and potential immunotherapeutic targets in multiple myeloma
Gong, B., Yuan, X., Zhang, Q., Jiang, T., Li, H., Xiao, J., Li, C., Luo, L., Shuai, P., Wang, L., Liu, Y., Yu, M., Shi, Y., Zhang, W., Zhang, Y., Zhong, L.
10.1101/2021.12.06.471423 — Posted: 2021-12-07 — Discussion: 2022-09-07  eLife
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability
Lu, Y., Cho, T., Mukherjee, S., Malik, A. A., Gonzlez-Foutel, N., Oh, R., Langille, E., Al-Zahrani, K., Lin, Z., Rotter, V., Ashton-Prolla, P., Chemes, L. B., Moffat, J., Gingras, A.-C., Oren, M., Durocher, D., Schramek, D.
10.1101/2022.03.13.483372 — Posted: 2022-03-14 — Discussion: 2022-09-07  Review Commons
CD81 partners with CD44 in promoting exosome biogenesis, tumor cluster formation, and lung metastasis in triple negative breast cancer
Ramos, E. K., Tsai, C.-F., Dashzeveg, N. K., Jia, Y., Cao, Y., Manu, M., Taftaf, R., Hoffmann, A. D., El-Shennawy, L., Gritsenko, M. A., Adorno-Cruz, V., Schuster, E. J., Scholten, D., Patel, D., Liu, X., Patel, P., Wray, B., Zhang, Y., Zhang, S., Moore, R. J., Schipma, M. J., Liu, T., Tokars, V. L., Cristofanilli, M., Shi, T., Shen, Y., Liu, H.
10.1101/2022.02.23.481674 — Posted: 2022-02-25 — Discussion: 2022-08-31  Review Commons
Pancreatic tumors activate arginine biosynthesis to adapt to myeloid-driven amino acid stress
Saab, J. J. A., Dzierozynski, L. N., Jonker, P. B., Zhu, Z., Chen, R. N., Oh, M., Sheehan, C., Macleod, K. F., Weber, C. R., Muir, A.
10.1101/2022.06.21.497008 — Posted: 2022-06-25 — Discussion: 2022-08-26  eLife
The CIC-ERF co-deletion underlies fusion independent activation of ETS family member, ETV1, to drive prostate cancer progression
Gupta, N., Song, H., Wu, W., Ponce, R., Lin, Y., Kim, J. W., Small, E., Feng, F., Huang, F. W., Okimoto, R.
10.1101/2022.01.26.477820 — Posted: 2022-01-28 — Discussion: 2022-08-25  eLife
eRNA profiling uncovers the enhancer landscape of oesophageal adenocarcinoma and reveals new deregulated pathways
Ahmed, I., Yang, S.-H., Ogden, S., Li, Y., Zhang, W., the OCCAMs consortium, , Sharrocks, A.
10.1101/2022.05.11.491502 — Posted: 2022-05-11 — Discussion: 2022-08-16  eLife
Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes
Monterisi, S., Michl, J., Hill, A. E., Hulikova, A., Abdullayeva, G., Bodmer, W. F., Swietach, P.
10.1101/2022.03.15.484462 — Posted: 2022-03-16 — Discussion: 2022-08-16  eLife
Therapeutic resistance to FLT3 inhibition is driven by a novel ATM/mTOR pathway regulating oxidative phosphorylation
Park, H. J., Gregory, M. A., Zaberezhnyy, V., Goodspeed, A., Jordan, C. T., Kieft, J. S., DeGregori, J.
10.1101/2022.02.14.480468 — Posted: 2022-02-16 — Discussion: 2022-08-13  eLife

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