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281 Reviews — eLife — Molecular Biology

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Omics-based insights into human liver reveal GTPase-driven mechanisms of MASLD progression in obesity
Zhao, Q., de Nardo, W., Wang, R., Zhong, Y., Keles, U., Zhao, L. N., Tay, H., Youhanna, S., Yan, M., Xie, Y., Kim, Y., Lee, S., Lim, R. L., Teo, G., Naraya, P., Burton, P. R., Lauschke, V. M., Choi, H., Watt, M. J., Kaldis, P.
10.1101/2025.01.13.632747 — Posted: 2025-01-14 — Discussion: 2026-02-23  eLife
Distinct Mechanisms for Inhibition of SARS-CoV-2 Main Protease: Dimerization Promoted by Peptidomimetic Inhibitors and Disrupted by Ebselen
Liu, C., Jia, Q., Zhao, C., Zhongping, Y.
10.1101/2025.11.16.688752 — Posted: 2025-11-17 — Discussion: 2026-02-17  eLife
EOLA1, a novel mitochondria-localized protein critical for heart functions via regulating mitochondrial translation
Chen, H., SHI, X., ZHANG, Y., Liu, N., Wang, R., Nan, Z., Cao, Y., Wang, D., Jin, Y., Meng, Q., Fan, S., Yao, J., Zhu, S., Hsu, C.-h., Zhu, P., Shi, Y.
10.64898/2026.01.12.699056 — Posted: 2026-01-12 — Discussion: 2026-02-16  eLife
Sperm motility restoration in mice suffering from oligo-astheno-teratozoospermia by in vivo injection and electroporation of naked mRNA
Vilpreux, C., Martinez, G., Court, M., Appaix, F., Duteyrat, J. L., Henry, M., Vollaire, J., Ayad, C., Yavuz, A., De Macedo, L., Chevalier, G., Lambert, E., Ahmed Conte, S., Giordani, E., Josserand, V., Brocard, J., Coutton, C., Verrier, B., Ray, P. F., Loeuillet, C., Arnoult, C., Escoffier, J.
10.1101/2023.12.12.571239 — Posted: 2023-12-14 — Discussion: 2026-02-10  eLife
EPB41L4A-AS1 long noncoding RNA acts in both cis- and trans-acting transcriptional regulation and controls nucleolar biology
Monziani, A., Unfried, J. P., Cvetanovic, T., Ulitsky, I.
10.1101/2025.04.08.647803 — Posted: 2025-04-09 — Discussion: 2026-01-28  eLife
FRG1 Regulates Nonsense-Mediated mRNA Decay by Modulating UPF1 Levels
Palo, A., Mohapatra, T., Singh, A., T, S., Mohanty, S., Swain, R. K., Dixit, M.
10.1101/2025.11.18.689056 — Posted: 2025-11-18 — Discussion: 2026-01-27  eLife
IMPACTS OF DNA METHYLATION ON H2A.Z DEPOSITION AND NUCLEOSOME STABILITY
Shih, R. M., Arimura, Y., Konishi, H. A., Funabiki, H.
10.1101/2025.07.31.667981 — Posted: 2025-07-31 — Discussion: 2026-01-23  eLife
The chromatin remodeller CHD4 controls both nucleosome integrity and transcription factor binding to promote activity of active regulatory elements and to prevent activation of silent enhancers
Koulle, A., Ogundele, O., Shah, D., Baker, I., Lopez, M., Reynolds, N., Ragheb, R., Laue, E. D., Hendrich, B.
10.1101/2025.08.29.672645 — Posted: 2025-08-29 — Discussion: 2026-01-19  eLife
Cardiac neurons expressing a glucagon-like receptor mediate cardiac arrhythmia induced by high-fat diet in Drosophila
Zhao, Y., Duan, J., van de Leemput, J., Han, Z.
10.1101/2023.12.13.571403 — Posted: 2023-12-13 — Discussion: 2026-01-19  eLife
A novel high-throughput single-cell DNA sequencing method reveals hidden genomic heterogeneity in the unicellular eukaryote Leishmania
Negreira, G. H., Monsieurs, P., Dujardin, J.-C., Domagalska, M. A.
10.1101/2025.09.10.675331 — Posted: 2025-09-10 — Discussion: 2026-01-15  eLife

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