bioRxiv/medRxiv TRiP Review Activity

45 Reviews — All Partners — Pharmacology and Toxicology

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Local Generation and Efficient Evaluation of Numerous Drug Combinations in a Single Sample
Elgart, V., Loscalzo, J.
10.1101/2022.12.13.520254 — Posted: 2022-12-15 — Discussion: 2023-04-01  eLife
Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics
Vuckovic, Z., Wang, J., Pham, V., Mobbs, J. I., Belousoff, M. J., Bhattarai, A., Burger, W. A. C., Thompson, G., Yeasmin, M., Leach, K., van der Westhuizen, E. T., Khajehali, E., Liang, Y.-L., Glukhova, A., Wootten, D., Lindsley, C. W., Tobin, A., Sexton, P., Danev, R., Valant, C., Miao, Y., Christopoulos, A., Thal, D. M.
10.1101/2022.09.27.509640 — Posted: 2022-09-28 — Discussion: 2023-03-29  eLife
The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury: a translational in vitro study
Ball, A. L., Jolly, C. E., Lyon, J., Alfirevic, A., Chadwick, A.
10.1101/2022.03.21.485109 — Posted: 2022-03-22 — Discussion: 2023-03-12  eLife
Immunological Synapse Dynamics Induced by Bispecific T-cell Engagers Predict Clinical Pharmacodynamics and Tumor Evolution across Anatomical Sites
Liu, C., Zhou, J., Kudlacek, S., Qi, T., Dunlap, T., Cao, Y.
10.1101/2022.04.18.488626 — Posted: 2022-04-18 — Discussion: 2023-03-02  eLife
A mechanism of uncompetitive inhibition of the serotonin transporter
Sandtner, W.
10.1101/2022.08.11.503588 — Posted: 2022-08-13 — Discussion: 2022-12-15  eLife
Metformin protects trabecular meshwork against oxidative injury via activating integrin/ROCK signals
Xu, L., Zhang, X., Zhao, Y., Cao, Y., Liang, Y.
10.1101/2022.06.30.498232 — Posted: 2022-07-03 — Discussion: 2022-11-01  eLife
Mechanism of hyperproteinemia-induced blood cell homeostasis imbalance in an animal model
Wang, G., Wang, Y., Li, J., Peng, R., Liang, X., Chen, X., Jiang, G., Shi, J., Si-ma, Y., Xu, S.
10.1101/2021.08.09.455622 — Posted: 2021-08-10 — Discussion: 2022-07-16  eLife
Robust and Efficient Assessment of Potency (REAP): A Quantitative Tool for Dose-response Curve Estimation
Zhou, S., Liu, X., Fang, X., Chinchilli, V. M., Wang, M., Wang, H.-G., Dokholyan, N. V., Shen, C., Lee, J. J.
10.1101/2021.11.20.469388 — Posted: 2021-11-22 — Discussion: 2022-06-13  eLife
Modeling osteoporosis to design and optimize pharmacologic therapies comprising multiple drug types
Jörg, D. J., Fuertinger, D. H., Cherif, A., Bushinsky, D. A., Mermelstein, A., Raimann, J. G., Kotanko, P.
10.1101/2021.12.17.473190 — Posted: 2021-12-20 — Discussion: 2022-05-19  eLife
A Single Multipurpose FSH-Blocking Therapeutic for Osteoporosis and Obesity
Gera, S., Kuo, T.-C., Korkmaz, F., Sant, D., DeMambro, V., Gumerova, A. A., Sudha, K., Padilla, A., Prevot, G., Munitz, J., Teunissen, A., van Leent, M. M. T., Post, T. G. J. M., Fernandes, J. C., Netto, J., Sultana, F., Shelly, E., Kumar, P., Cullen, L., Chatterjee, J., Miyashita, S., Kannangara, H., Bhongade, M., Ievleva, K., Muradova, V., Batista, R., Robinson, C., Macdonald, A., Babunovic, S., Saxena, M., Meseck, M., Caminis, J., Iqbal, J., New, M. I., Ryu, V., Kim, S.-M., Cao, J., Zaidi, N., Fayad, Z. A., Lizneva, D., J. Rosen, C., Yuen, T., Zaidi, M.
10.1101/2022.02.28.482279 — Posted: 2022-03-02 — Discussion: 2022-04-29  eLife

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