bioRxiv/medRxiv TRiP Review Activity

51 Reviews — All Partners — Pharmacology and Toxicology

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Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology
Heitmann, S., Vandenberg, J. I., Hill, A. P.
10.1101/2023.04.19.537441 — Posted: 2023-04-20 — Discussion: 2023-11-06  eLife
Discovery and biological evaluation of a potent small molecule CRM1 inhibitor for its selective ablation of extranodal NK/T cell lymphoma
Liu, H., Liu, M., Tian, X., Wang, H., Gao, J., Li, H., Zhao, Z., Liu, Y., Liu, C., Chen, X., Yang, Y.
10.1101/2022.12.06.519362 — Posted: 2022-12-10 — Discussion: 2023-10-03  eLife
A novel triptolide analog downregulates NF-κB and induces mitochondrial apoptosis pathways in human pancreatic cancer
Tian, Q., Zhang, P., Wang, Y., Si, Y., Yin, D., Weber, C. R., Fishel, M., Pollok, K. E., Qiu, B., Xiao, F., Chong, A.
10.1101/2023.02.15.528599 — Posted: 2023-02-15 — Discussion: 2023-09-28  eLife
Death by a Thousand Cuts -- Combining Kinase Inhibitors for Selective Target Inhibition and Rational Polypharmacology
Outhwaite, I. R., Singh, S., Berger, B.-T., Knapp, S., Chodera, J. D., Seeliger, M. A.
10.1101/2023.01.13.523972 — Posted: 2023-01-16 — Discussion: 2023-09-27  eLife
Characterization of the bioaccumulation and toxicity of copper pyrithione, an antifouling compound, on juveniles of rainbow trout
Bourdon, C., Cachot, J., Gonzalez, P., Couture, P.
10.1101/2023.01.31.526498 — Posted: 2023-01-31 — Discussion: 2023-09-25  Peer Community In
A generic binding pocket for small molecule IKs activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes
Chan, M., Sahakyan, H., Eldstrom, J., Sastre, D., Wang, Y., Dou, Y., Pourrier, M., Vardanian, V., Fedida, D.
10.1101/2023.02.27.530167 — Posted: 2023-02-27 — Discussion: 2023-07-31  eLife
Local Generation and Efficient Evaluation of Numerous Drug Combinations in a Single Sample
Elgart, V., Loscalzo, J.
10.1101/2022.12.13.520254 — Posted: 2022-12-15 — Discussion: 2023-04-01  eLife
Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics
Vuckovic, Z., Wang, J., Pham, V., Mobbs, J. I., Belousoff, M. J., Bhattarai, A., Burger, W. A. C., Thompson, G., Yeasmin, M., Leach, K., van der Westhuizen, E. T., Khajehali, E., Liang, Y.-L., Glukhova, A., Wootten, D., Lindsley, C. W., Tobin, A., Sexton, P., Danev, R., Valant, C., Miao, Y., Christopoulos, A., Thal, D. M.
10.1101/2022.09.27.509640 — Posted: 2022-09-28 — Discussion: 2023-03-29  eLife
The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury: a translational in vitro study
Ball, A. L., Jolly, C. E., Lyon, J., Alfirevic, A., Chadwick, A.
10.1101/2022.03.21.485109 — Posted: 2022-03-22 — Discussion: 2023-03-12  eLife
Immunological Synapse Dynamics Induced by Bispecific T-cell Engagers Predict Clinical Pharmacodynamics and Tumor Evolution across Anatomical Sites
Liu, C., Zhou, J., Kudlacek, S., Qi, T., Dunlap, T., Cao, Y.
10.1101/2022.04.18.488626 — Posted: 2022-04-18 — Discussion: 2023-03-02  eLife

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