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437 Reviews — eLife — Biophysics

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Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B
Mehlman, T. S., Biel, J. T., Azeem, S. M., Nelson, E. R., Hossain, S., Dunnett, L. E., Paterson, N. G., Douangamath, A., Talon, R., Axford, D., Orins, H., von Delft, F., Keedy, D. A.
10.1101/2022.11.02.514751 — Posted: 2022-11-03 — Discussion: 2023-01-31  eLife
Conserved allosteric inhibition mechanism in SLC1 transporters
Dong, Y., Wang, J., Garibsingh, R.-A., Hutchinson, K., Shi, Y., Eisenberg, G., Yu, X., Schlessinger, A., Grewer, C.
10.1101/2022.09.21.508810 — Posted: 2022-09-22 — Discussion: 2023-01-30  eLife
Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk and enhanced NTD dynamics
Braet, S. M., Buckley, T. S., Venkatakrishnan, V., Dam, K.-M. A., Bjorkman, P. J., Anand, G. S.
10.1101/2022.08.26.505369 — Posted: 2022-08-29 — Discussion: 2023-01-26  eLife
Gating interactions steer loop conformational changes in the active site of the L1 metallo-β-lactamase
Zhao, Z., Shen, X., Chen, S., Gu, J., Wang, H., Mojica, M. F., Samanta, M., Bhowmik, D., Vila, A. J., Bonomo, R. A., Haider, S.
10.1101/2022.10.25.513716 — Posted: 2022-10-27 — Discussion: 2023-01-19  eLife
The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins
Miller, A. N., Houlihan, P. R., Matamala, E., Cabezas-Bratesco, D., Lee, G. Y., Cristofori-Armstrong, B., Dilan, T. L., Sanchez-Martinez, S., Matthies, D., Yan, R., Yu, Z., Ren, D., Brauchi, S. E., Clapham, D. E.
10.1101/2022.09.02.506428 — Posted: 2022-09-03 — Discussion: 2023-01-10  eLife
Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains
Meller, A., Lotthammer, J. M., Smith, L. G., Novak, B., Lee, L. A., Kuhn, C. C., Greenberg, L., Leinwand, L. A., Greenberg, M. J., Bowman, G. R.
10.1101/2022.09.05.506254 — Posted: 2022-09-05 — Discussion: 2023-01-09  eLife
Voltage clamp fluorometry analysis of the P2X7 receptor suggests a limited conformational interplay between extracellular ATP binding and the intracellular ballast domain
Durner, A., Durner, E., Nicke, A.
10.1101/2022.08.31.506013 — Posted: 2022-09-01 — Discussion: 2023-01-02  eLife
Chloride ion evokes taste sensation by binding to the extracellular ligand-binding domain of sweet/umami taste receptors
Atsumi, N., Yasumatsu, K., Takashina, Y., Ito, C., Yasui, N., Yamashita, A.
10.1101/2022.02.23.481615 — Posted: 2022-02-24 — Discussion: 2022-12-29  eLife
Motor processivity and speed determine structure and dynamics of microtubule-motor assemblies
Banks, R. A., Galstyan, V., Lee, H. J., Hirokawa, S., Ierokomos, A., Ross, T. D., Bryant, Z., Thomson, M., Phillips, R.
10.1101/2021.10.22.465381 — Posted: 2021-10-23 — Discussion: 2022-12-21  eLife
Synthetic analysis of chromatin tracing and live-cell imaging indicates pervasive spatial coupling between genes
Bohrer, C. H., Larson, D. R.
10.1101/2022.07.07.499202 — Posted: 2022-07-08 — Discussion: 2022-12-21  eLife

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