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421 Reviews — eLife — Biophysics

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Zn2+ potentiation of OTOP proton channels identifies structural elements of the gating apparatus
Teng, B., Kaplan, J., Liang, Z., Goldschen-Ohm, M. P., Liman, E.
10.1101/2022.12.15.520539 — Posted: 2022-12-18 — Discussion: 2023-03-24  eLife
A pH-dependent cluster of charges in a conserved cryptic pocket on flaviviral envelopes
Zuzic, L., Marzinek, J. K., Anand, G. S., Warwicker, J., Bond, P. J.
10.1101/2022.07.12.499710 — Posted: 2022-07-13 — Discussion: 2023-03-18  eLife
Conformational and oligomeric states of SPOP from small-angle X-ray scattering and molecular dynamics simulations
Thomasen, F. E., Cuneo, M. J., Mittag, T., Lindorff-Larsen, K.
10.1101/2022.10.08.511432 — Posted: 2022-10-08 — Discussion: 2023-02-15  eLife
Cell size scaling laws: a unified theory
Rollin, R., Joanny, J.-F., Sens, P.
10.1101/2022.08.01.502021 — Posted: 2022-08-03 — Discussion: 2023-02-10  eLife
Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B
Mehlman, T. S., Biel, J. T., Azeem, S. M., Nelson, E. R., Hossain, S., Dunnett, L. E., Paterson, N. G., Douangamath, A., Talon, R., Axford, D., Orins, H., von Delft, F., Keedy, D. A.
10.1101/2022.11.02.514751 — Posted: 2022-11-03 — Discussion: 2023-01-31  eLife
Conserved allosteric inhibition mechanism in SLC1 transporters
Dong, Y., Wang, J., Garibsingh, R.-A., Hutchinson, K., Shi, Y., Eisenberg, G., Yu, X., Schlessinger, A., Grewer, C.
10.1101/2022.09.21.508810 — Posted: 2022-09-22 — Discussion: 2023-01-30  eLife
Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk and enhanced NTD dynamics
Braet, S. M., Buckley, T. S., Venkatakrishnan, V., Dam, K.-M. A., Bjorkman, P. J., Anand, G. S.
10.1101/2022.08.26.505369 — Posted: 2022-08-29 — Discussion: 2023-01-26  eLife
Gating interactions steer loop conformational changes in the active site of the L1 metallo-β-lactamase
Zhao, Z., Shen, X., Chen, S., Gu, J., Wang, H., Mojica, M. F., Samanta, M., Bhowmik, D., Vila, A. J., Bonomo, R. A., Haider, S.
10.1101/2022.10.25.513716 — Posted: 2022-10-27 — Discussion: 2023-01-19  eLife
The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins
Miller, A. N., Houlihan, P. R., Matamala, E., Cabezas-Bratesco, D., Lee, G. Y., Cristofori-Armstrong, B., Dilan, T. L., Sanchez-Martinez, S., Matthies, D., Yan, R., Yu, Z., Ren, D., Brauchi, S. E., Clapham, D. E.
10.1101/2022.09.02.506428 — Posted: 2022-09-03 — Discussion: 2023-01-10  eLife
Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains
Meller, A., Lotthammer, J. M., Smith, L. G., Novak, B., Lee, L. A., Kuhn, C. C., Greenberg, L., Leinwand, L. A., Greenberg, M. J., Bowman, G. R.
10.1101/2022.09.05.506254 — Posted: 2022-09-05 — Discussion: 2023-01-09  eLife

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