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281 Reviews — eLife — Molecular Biology

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Impaired ERK MAPK activation in mature osteoblasts enhances bone formation via the mTOR pathway
Kim, J.-M., Yang, Y.-S., Hong, J., Chaugule, S., Chun, H., van der Meulen, M. C. H., Xu, R., Greenblatt, M. B., Shim, J.-H.
10.1101/2022.01.24.477465 — Posted: 2022-01-24 — Discussion: 2022-06-08  eLife
METTL18-mediated histidine methylation on RPL3 modulates translation elongation for proteostasis maintenance
Matsuura-Suzuki, E., Shimazu, T., Takahashi, M., Kotoshiba, K., Suzuki, T., Kashiwagi, K., Sohtome, Y., Akakabe, M., Sodeoka, M., Dohmae, N., Ito, T., Shinkai, Y., Iwasaki, S.
10.1101/2021.07.29.454307 — Posted: 2021-07-29 — Discussion: 2022-05-27  eLife
Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
Flynn, J. M., Samant, N., Schneider-Nachum, G., Barkan, D. T., Yilmaz, N. K., Schiffer, C. A., Moquin, S. A., Dovala, D., Bolon, D. N. A.
10.1101/2022.01.26.477860 — Posted: 2022-01-26 — Discussion: 2022-05-27  eLife
Unleashing a Novel Function of Endonuclease G in Mitochondrial Genome Instability
Dahal, S., Siddiqua, H., Sharma, S., Babu, R. K., Manjunath, M., Sharma, S., Choudhary, B., Raghavan, S.
10.1101/2021.05.27.445952 — Posted: 2021-05-27 — Discussion: 2022-05-16  eLife
DExCon, DExogron, LUXon: on-demand expression control of endogenous genes reveals differential dynamics of Rab11 family members
Gemperle, J., Harrison, T., Flett, C., Adamson, A. D., Caswell, P. T.
10.1101/2021.12.03.471086 — Posted: 2021-12-03 — Discussion: 2022-05-09  eLife
A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation
Wang, L., Boone, M., Lawrence, R. E., Frost, A., Walter, P., Schoof, M.
10.1101/2021.12.03.471181 — Posted: 2021-12-06 — Discussion: 2022-04-13  eLife
MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation
Romero-Becerra, R., Mora, A., Manieri, E., Sanz, L., Nikolic, I., Santamans, A. M., Montalvo-Romeral, V., Cruz, F. M., Rodriguez, E., Leiva-Vega, L., Bondia, V., Filgueiras-Rama, D., Jimenez-Borreguero, L. J., Jalife, J., Gonzalez-Teran, B., Sabio, G.
10.1101/2021.11.15.468612 — Posted: 2021-11-16 — Discussion: 2022-04-08  eLife
Structural basis of streptomycin off-target binding to human mitoribosome
Itoh, Y., Khawaja, A., Singh, V., Naschberger, A., Rorbach, J., Amunts, A.
10.1101/2022.02.02.478878 — Posted: 2022-02-02 — Discussion: 2022-04-01  eLife
The RNA helicase DDX39B activates FOXP3 RNA splicing to control T regulatory cell fate
Hirano, M., Galarza-Munoz, G., Schott, G., Wang, L., Nagasawa, C., Antonia, A. L., Jain, V., Yu, X., Widen, S. G., Briggs, F. B., Gregory, S. G., Ko, D. C., Fagg, W. S., Bradrick, S., Garcia-Blanco, M. A.
10.1101/2022.01.25.477795 — Posted: 2022-01-27 — Discussion: 2022-03-29  eLife
Concerted modification of nucleotides at functional centers of the ribosome revealed by single-molecule RNA modification profiling
Bailey, A. D., Talkish, J., Ding, H., Igel, H., Duran, A., Mantripragada, S., Paten, B., Ares, M.
10.1101/2021.12.16.472988 — Posted: 2021-12-17 — Discussion: 2022-03-25  eLife

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