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268 Reviews — eLife — Cancer Biology

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Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS
Ilter, M., Kasmer, R., Jalalypour, F., Atilgan, C., Topcu, O., Karakas, N., Sensoy, O.
10.1101/2022.04.24.489309 — Posted: 2022-04-24 — Discussion: 2022-09-15  eLife
Cancer missense mutations in the BRC repeats of BRCA2 protein disrupt RAD51 binding and activity leading to chemotherapeutic sensitivity
Jimenez-Sainz, J., Mathew, J., Garbarino, J., Eder, J. P., Jensen, R. B.
10.1101/2021.09.24.461749 — Posted: 2021-09-25 — Discussion: 2022-09-09  eLife
Covalent Disruptor of YAP-TEAD Association Suppresses Defective Hippo Signaling
Fan, M., Lu, W., Che, J., Kwiatkowski, N. P., Gao, Y., Seo, H.-S., Ficarro, S. B., Gokhale, P. C., Liu, Y., Geffken, E. A., Lakhani, J., Song, K., Kuljanin, M., Ji, W., Jiang, J., He, Z., Tse, J., Boghossian, A. S., Rees, M. G., Ronan, M. M., Roth, J. A., Mancias, J. D., Marto, J. A., Dhe-Paganon, S., Zhang, T., Gray, N.
10.1101/2022.05.10.491316 — Posted: 2022-05-11 — Discussion: 2022-09-09  eLife
Revised International Staging System (R-ISS) stage-dependent analysis uncovers oncogenes and potential immunotherapeutic targets in multiple myeloma
Gong, B., Yuan, X., Zhang, Q., Jiang, T., Li, H., Xiao, J., Li, C., Luo, L., Shuai, P., Wang, L., Liu, Y., Yu, M., Shi, Y., Zhang, W., Zhang, Y., Zhong, L.
10.1101/2021.12.06.471423 — Posted: 2021-12-07 — Discussion: 2022-09-07  eLife
Pancreatic tumors activate arginine biosynthesis to adapt to myeloid-driven amino acid stress
Saab, J. J. A., Dzierozynski, L. N., Jonker, P. B., Zhu, Z., Chen, R. N., Oh, M., Sheehan, C., Macleod, K. F., Weber, C. R., Muir, A.
10.1101/2022.06.21.497008 — Posted: 2022-06-25 — Discussion: 2022-08-26  eLife
The CIC-ERF co-deletion underlies fusion independent activation of ETS family member, ETV1, to drive prostate cancer progression
Gupta, N., Song, H., Wu, W., Ponce, R., Lin, Y., Kim, J. W., Small, E., Feng, F., Huang, F. W., Okimoto, R.
10.1101/2022.01.26.477820 — Posted: 2022-01-28 — Discussion: 2022-08-25  eLife
Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes
Monterisi, S., Michl, J., Hill, A. E., Hulikova, A., Abdullayeva, G., Bodmer, W. F., Swietach, P.
10.1101/2022.03.15.484462 — Posted: 2022-03-16 — Discussion: 2022-08-16  eLife
eRNA profiling uncovers the enhancer landscape of oesophageal adenocarcinoma and reveals new deregulated pathways
Ahmed, I., Yang, S.-H., Ogden, S., Li, Y., Zhang, W., the OCCAMs consortium, , Sharrocks, A.
10.1101/2022.05.11.491502 — Posted: 2022-05-11 — Discussion: 2022-08-16  eLife
Therapeutic resistance to FLT3 inhibition is driven by a novel ATM/mTOR pathway regulating oxidative phosphorylation
Park, H. J., Gregory, M. A., Zaberezhnyy, V., Goodspeed, A., Jordan, C. T., Kieft, J. S., DeGregori, J.
10.1101/2022.02.14.480468 — Posted: 2022-02-16 — Discussion: 2022-08-13  eLife
GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
Cordova, R., Misra, J., Amin, P. H., Klunk, A. J., Damayanti, N. P., Carlson, K. R., Elmendorf, A. J., Hyeong-Geug, K., Mirek, E. T., Miller, M. J., Dong, X. C., Cheng, L., Anthony, T. G., Pili, R., Wek, R. C., Staschke, K. A.
10.1101/2022.06.17.496598 — Posted: 2022-06-18 — Discussion: 2022-08-12  eLife

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