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285 Reviews — eLife — Cancer Biology

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Nerve Injury-Induced Protein 2 Is Necessary for the Lysosome Membrane Integrity and Protects Cells from Ferroptosis
Zhang, J., Bustamante, M., Shi, Y., Nakajima, K.-i., Chen, X.
10.64898/2026.02.09.704867 — Posted: 2026-02-11 — Discussion: 2026-03-17  eLife
Intrinsic bioenergetic adaptations compensate for reduced mitochondrial content in HER2-driven mammary tumors
Frangos, S. M., Brunetta, H. S., Wang, D., Jabile, M. J. T., Ma, D. W. L., Muller, W., Khursigara, C., Fisher-Wellman, K. H., Steinberg, G., Holloway, G. P.
10.1101/2024.11.03.621754 — Posted: 2024-11-03 — Discussion: 2026-03-12  eLife
Impacts of mutation accumulation and order on tumor initiation revealed by engineered murine colorectal cancer organoids
Li, Y., Xie, X., Deng, D., Sun, Z., Huang, Z., Tang, Y., Fang, L., Chen, W., Zhu, Q.
10.64898/2026.01.05.697837 — Posted: 2026-01-06 — Discussion: 2026-02-27  eLife
Blocking SHP2 benefits FGFR2 inhibitor and overcomes its resistance in FGFR2-amplified gastric cancer
Zhang, Y., Wang, H., Wei, Y., Pan, Y., Song, X., Shi, T., Shao, J., Yu, L., Liu, B., Wang, Y., Wei, J.
10.1101/2024.11.04.621870 — Posted: 2024-11-06 — Discussion: 2026-02-19  eLife
Reduction in ETFDH expression optimizes cancer cell bioenergetics
Papadopoli, D., Palia, R., Jovanovic, P., Tabaries, S., Ciccolini, E., Sabourin, V., Igelmann, S., McLaughlan, S., Zhan, L., Kim, H., Chekkal, N., Szkop, K. J., Bertomeu, T., Zeng, J., Vassalakis, J., Afzali, F., Mzoughi, S., Guccione, E., Tyers, M., Avizonis, D., Larsson, O., Postovit, L.-M., Djuranovic, S., Ursini-Siegel, J., Siegel, P. M., Pollak, M., Topisirovic, I.
10.1101/2024.10.25.620155 — Posted: 2024-10-25 — Discussion: 2026-02-17  eLife
DBD-α4 helix of EWS::FLI is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma
Bayanjargal, A., Taslim, C., Showpnil, I. A., Selich-Anderson, J., Crow, J. C., Lessnick, S. L., Theisen, E. R.
10.1101/2024.01.31.578127 — Posted: 2024-01-31 — Discussion: 2026-02-17  eLife
A mediterranean-mimicking diet harnesses gut microbiota-derived 3-IAA to rejuvenate T cell
Yu, X., Li, W., Feng, H., Li, Z., Zheng, H., Sun, S., Li, J., Li, B., Wu, Q.
10.64898/2026.01.05.697620 — Posted: 2026-01-08 — Discussion: 2026-02-11  eLife
METTL5 Blockade Enhances Anti-Tumor Immune Response via Inducing Neoantigen Generation
Zhang, Y., Shi, X., Wang, Y., Wang, R., Cao, Y., Chen, H.
10.1101/2025.06.06.658288 — Posted: 2025-06-07 — Discussion: 2026-02-11  eLife
PTEN restrains SHH medulloblastma growth through cell autonomous and nonautonomous mechanisms
Lao, Z., El Nagar, S., Liang, Y., Stephen, D., Joyner, A. L.
10.1101/2025.07.31.667996 — Posted: 2025-08-02 — Discussion: 2026-01-28  eLife
Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1+ TAMs and CD8+ T cells
Dong, F., Zhang, S., Song, K., Jiang, L., Hu, L.-P., Li, Q., Zhang, X.-L., li, j., Feng, M., Cai, Z.-W., Yao, H.-F., Li, R.-k., Li, H., Chen, J., Hu, X., Wang, J., Jiang, C., Zhu, H. H., Wang, C., Da, L., Zhang, Z., Bao, Z., Wang, X., Jiang, S.
10.1101/2024.10.15.618536 — Posted: 2024-10-18 — Discussion: 2026-01-28  eLife

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