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215 Reviews — eLife — Genetics

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Relating pathogenic loss-of function mutations in humans to their evolutionary fitness costs
Agarwal, I., Fuller, Z. L., Myers, S., Przeworski, M.
10.1101/2022.08.11.503594 — Posted: 2022-08-12 — Discussion: 2022-11-11  eLife
Methylglyoxal-derived hydroimidazolone, MG-H1, increases food intake by altering tyramine signaling via the GATA transcription factor ELT-3 in Caenorhabditis elegans
Muthaiyan Shanmugam, M., Chaudhuri, J., Sellegounder, D., Sahu, A. K., Guha, S., Chamoli, M., Hodge, B., Roberts, C., Lithgow, G., Sarpong, R., Kapahi, P.
10.1101/2022.08.18.504374 — Posted: 2022-08-19 — Discussion: 2022-11-04  eLife
Evidence for RNA or protein transport from somatic tissues to the male reproductive tract in mouse
Rinaldi, V., Messemer, K., Desevin, K., Sun, F., Berry, B., Kukreja, S., Tapper, A., Wagers, A., Rando, O.
10.1101/2022.02.08.479624 — Posted: 2022-02-10 — Discussion: 2022-10-28  eLife
CIRKO: A chemical-induced reversible gene knockout system for studying gene function in situ
Shi, H., Jin, Q., Chen, F., Ouyang, Z., Gou, S., Liu, X., Li, L., Mu, S., Lai, C., Zhang, Q., Ye, Y., Wang, K., Lai, L.
10.1101/2022.08.31.506064 — Posted: 2022-09-03 — Discussion: 2022-10-23  eLife
Establishment and Characterization of Novel Canine Organoids with Organ-Specific Physiological Similarity
Zdyrski, C., Gabriel, V., Ospina, O. E., Wickham, H., Sahoo, D. K., Dao, K., Aguilar Meza, L. S., Bedos, L., Honold, S., Pineyro, P., Mochel, J. P., Allenspach, K.
10.1101/2022.07.15.500059 — Posted: 2022-07-16 — Discussion: 2022-10-18  eLife
A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene
Ding, Y., Lang, D., Yan, J., Bu, H., Li, H., Jiao, K., Yang, J., Le, T., Clark, K., Ekker, S. C., Cao, H., Zhang, Y., Li, Y., Glukhov, A. V., Xu, X. C.
10.1101/2022.01.25.477752 — Posted: 2022-01-26 — Discussion: 2022-10-07  eLife
Contrasting effects of Ksr2, an obesity gene, on trabecular bone volume and bone marrow adiposity
Gomez, G. A., Rundle, C., Xing, W., Kesavan, C., Pourteymoor, S., Lewis, R. E., Powell, D. R., Mohan, S.
10.1101/2022.08.21.504689 — Posted: 2022-08-21 — Discussion: 2022-09-30  eLife
Finding the strongest gene drive: Simulations reveal unexpected performance differences between Anopheles homing suppression drive candidates
Champer, S. E., Kim, I. K., Clark, A. G., Messer, P. W., Champer, J.
10.1101/2022.03.28.486009 — Posted: 2022-03-28 — Discussion: 2022-09-29  eLife
Genetic Basis of Variation in Ubiquitin-Proteasome System Activity
Collins, M. A., Mekonnen, G., Albert, F. W.
10.1101/2021.05.05.442832 — Posted: 2021-05-06 — Discussion: 2022-09-23  eLife
Gene interaction perturbation network deciphers a high-resolution taxonomy in colorectal cancer
Liu, Z., Weng, S., Dang, Q., Xu, H., Ren, Y., Guo, C., Xing, Z., Sun, Z., Han, X.
10.1101/2022.09.02.506442 — Posted: 2022-09-05 — Discussion: 2022-09-09  eLife

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