bioRxiv/medRxiv TRiP Review Activity

50 Reviews — All Partners — Pharmacology and Toxicology

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Magnesium isoglycyrrhizinate alleviates alcohol-associated liver disease through targeting HSD11B1

Xiao, L., Li, L., Wu, S., Che, Z., Du, Y., Zheng, J., Yan, J., Wang, H., Zhang, H., Li, Y., Xiao, J.

10.1101/2025.10.02.679991 — Posted: 2025-10-03 — Discussion: 2026-02-06 eLife

Efficient Recombinant Production and Functional Characterisation of Cytotoxic and Haemotoxic Snake Venom Metalloproteinases

Hall, S., Cardoso, I. A., Wilkinson, M. C., Carretero, M. M., Lingappa, S., Rand, B., Shen, D., Boldrini-Franca, J., Stenner, R., Balchin, G., Hus, K. K., Vincentelli, R., Mumford, A., Casewell, N. R., Berger, I., Schaffitzel, C.

10.1101/2025.06.27.661748 — Posted: 2025-06-30 — Discussion: 2026-01-21 eLife

Single-cell transcriptomics identifies a dampened neutrophil function and accentuated T-cell cytotoxicity in tobacco flavored e-cigarette exposed mouse lungs

Kaur, G., Lamb, T., Tjitropranoto, A., Rahman, I.

10.1101/2025.02.17.638715 — Posted: 2025-02-22 — Discussion: 2026-01-05 eLife

In search of nonlipogenic ABCA1 inducers (NLAI): precision coregulator TR-FRET identifies diverse signatures for LXR ligands

Laham, M. S., Ackerman-Berrier, M. S., Alam, F., Turner, S., Musku, G. R., Penton, C., Musku, S. R., Rana, M., Kumar, S., Annadurai, A., Sulaiman, M. I., Ma, N., Thatcher, G. R.

10.1101/2025.09.12.675753 — Posted: 2025-09-17 — Discussion: 2025-11-25 eLife

Quinolines interfere with heme-mediated activation of artemisinins

Rosenthal, M., Goldberg, D.

10.1101/2025.08.19.670585 — Posted: 2025-08-23 — Discussion: 2025-11-03 eLife

Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injury

Zhu, Y., Deng, C., Chen, B., He, J., Liu, Y., Peng, C., Shan, Z.

10.1101/2025.08.21.671501 — Posted: 2025-08-25 — Discussion: 2025-10-17 eLife

Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules

Cassell, S. J., Li, W., Krautwald, S., Khoshouei, M., Lee, Y. T., Hou, J., Guan, W., Peukert, S., Weihofen, W., Whicher, J.

10.1101/2025.05.22.655589 — Posted: 2025-05-27 — Discussion: 2025-09-10 eLife

Interleukin-4 induces CD11c+ microglia leading to amelioration of neuropathic pain in mice

Kohno, K., Shirasaka, R., Hirose, K., Masuda, T., Tsuda, M.