Channel:  Aligning Science Across Parkinson's (ASAP)

521 Articles

Programmable self-assembling system to model intracellular protein aggregation and decode neurodegenerative diseases
Fan, Y., Hoang, J., Steele, C., Benchetrit, Y., Dutta, S., Coughlin, G., Appling, N., Ding, X., Lin, C., Qu, Z., Mackey, E. D., Gradinaru, V.
10.1101/2025.03.06.641009 — Posted: 2025-10-06
Polygenic risk scores and Parkinson's disease in South Africa: Moving towards ancestry-informed disease prediction
Step, K., Ndong Sima, C. A. A., Grant, S., Kim, J. J., Waldo, E., Bardien, S., Mata, I., Global Parkinson's Genetics Program
10.1101/2025.09.29.25336747 — Posted: 2025-09-30
Fall frequency, Risk Factors, and Outcomes in Parkinson's disease: A Cross-Sectional Analysis
Vizcarra, J. A., Hefter, K., Lafontant, D.-E., Duong, M. T., Ertefaie, A., Litt, B., Bassett, D. S., Siderowf, A., The Parkinson's Progression Markers Initiative
10.1101/2025.08.05.25332959 — Posted: 2025-09-25
Faecalibacterium prausnitzii, depleted in the Parkinson's disease microbiome, improves motor deficits in α-synuclein overexpressing mice
Moiseyenko, A., Antonello, G., Schonhoff, A. M., Boktor, J. C., Long, K., Dirks, B., Oguienko, A. D., Winnett, A. V., Simpson, P., Daeizadeh, D., Ismagilov, R. F., Krajmalnik-Brown, R., Segata, N., Waldron, L. D., Mazmanian, S. K.
10.1101/2025.09.18.677192 — Posted: 2025-09-21
A molecular atlas of cell-type specific signatures in the parkinsonian striatum.
Graziano, M., Mantas, I., Masarapu, Y., Frapard, S., Garza, R., Adami, A., Fazal, S., Quaegebeur, A., Barker, R., Jakobsson, J., Giacomello, S., Meletis, K.
10.1101/2025.09.09.675138 — Posted: 2025-09-10
TDP-43 loss of function drives aberrant splicing in Parkinson's disease
Brenton, J. W., Follett, J., Nirujogi, R., Toomey, C. E., Lopez-Garcia, P., Evans, J. R., Lee, Y. J., Syed, K. M., Rocamora Perez, G., Fairbrother-Browne, A., D'Sa, K., Grant-Peters, M., Lachica, J., Hicks, A. R., Wagen, A. Z., O'Callaghan, B., Macpherson, H., Montgomery, K.-a., Busquets, O., Reynolds, R. H., Garcia Ruiz, S., Cao, T., Chen, Z., Plun-Favreau, H., Wong, P. C., Farrer, M., Lashley, T., Soldner, F., Hockemeyer, D., Alessi, D., Wood, N. W., Hardy, J., Rio, D. C., Jaunmuktane, Z., Gustavsson, E. K., Gandhi, S., Ryten, M.
10.1101/2025.09.04.673943 — Posted: 2025-09-09
Proteome-wide impact of LRRK1 and 2 inhibitors on protein interactions and phosphorylation
Jansen, J., Wendel, M., Raig, N. D., Kraus, T. V., Surridge, K. J., Mahesula, S., Richter-Muller, N., Mathea, S., Reck-Peterson, S. L., Knapp, S., Stengel, F.
10.1101/2025.09.03.674114 — Posted: 2025-09-07
The LRRK2 p.A419V variant associates with risk of Parkinson disease in the East Asian population and an evaluation on age of onset
Lim, K. S., Perinan, M. T., Chew, E. G. Y., Lee, P. S., Akcimen, F., Lim, J. L., Koretsky, M. J., Funayama, M., Yoshino, H., Hattori, N., Kaiyrzhanov, R., Houlden, H., Isayan, M., Tay, Y. W., Toh, T. S., Lit, L.-C., Khairul Anuar, A. N., Ding, H. X., Screven, L., Mohamed Ibrahim, N., Lin, C.-H., Kim, H.-J., Lee, J.-Y., Chung, S. J., Foo, J. N., Tan, E.-K., Lim, S.-Y., Tan, A. H., Bandres Ciga, S., Ahmad-Annuar, A., Global Parkinson's Genetics Program (GP2)
10.1101/2025.08.28.25333987 — Posted: 2025-09-02
Increased serum Neurofilament light chain levels in Parkinson's Disease patients carrying the p.A53T SNCA mutation: Data from the PPMI study
Papagiannakis, N., Simitsi, A. M., Koros, C., Stefanis, L., The Parkinson's Progression Markers Initiative
10.1101/2025.08.28.25334674 — Posted: 2025-08-29
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson's disease
Evans, J. R., Grant-Peters, M., Beckwith, J. S., Toomey, C. E., Popovic, R., Breiter, J. C., Brenton, J. W., Fairbrother-Browne, A., Strohbuecker, S., Lachica, J., Rodriguez-Lopez, M., Brock, E. E., Fu, B., Nahidiazar, L., Lopez-Garcia, P., Ferguson, R., Saleeb, R. S., Lucas-Clarke, H., Penverne, A., D'Sa, K., Pang, C. W., Horrocks, M. H., Vendruscolo, M., Wood, N., Lee, S. F., Ryten, M., Gandhi, S.
10.1101/2025.08.25.671921 — Posted: 2025-08-28

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