Channel: Aligning Science Across Parkinson's (ASAP)

521 Articles

The age at onset of LRRK2 p.Gly2019Ser Parkinson's disease across ancestries and countries of origin

Lüth, T., Laabs, B.-H., Sendel, S., König, I. R., Caliebe, A., Noyce, A. J., Screven, L. A., Bardien, S., Farrer, M., Hentati, F., Klein, C., Ben Sassi, S., Trinh, J., Global Parkinson's Genetics Program (GP2)

10.1101/2025.06.04.25327685 — Posted: 2025-06-09

Genetic modulation of immune gene co-expression in the aged mouse hippocampus by the Apbb1ip locus

Tomkins, J. E., Methi, A., Bouland, G., Doludda, B., Murphy, K., Miller, J. A., Overall, R. W., Mozhui, K.

10.1101/2025.06.04.657838 — Posted: 2025-06-08

Parkinson's disease-vulnerable and -resilient dopamine neurons display opposite responses to excitatory input

Hadjas, L. C., Kollman, G. J., Linderhof, L., Xia, M., Mansur, S., Saint-Pierre, M., Lim, B., Lee, E. B., Cicchetti, F., Awatramani, R., Hollon, N. G., Hnasko, T. S.

10.1101/2025.06.03.657460 — Posted: 2025-06-07

Bridging Pleiotropic Mechanisms in Leprosy Type-1 Reactions and Neurodegenerative diseases

Fava, V. M., Perico, J., Orlova, M., Dallmann-Sauer, M., Xu, Y. Z., Van Thuc, N., Thai, V. H., Belone, A. F., Latini, A. C. P., Schurr, E.

10.1101/2025.06.05.25329059 — Posted: 2025-06-06

RAB32-linked Parkinson's disease: Deep phenotyping, MDSGene literature review, and application of SynNeurGe criteria

Kleinz, T., Cavallieri, F., Borsche, M., Toschi, G., Valzania, F., Fioravanti, V., Valente, E. M., Mitrotti, P., Avenali, M., Zittel, S., Born, R., Matarazzo, M., Di Fonzo, A., Monfrini, E., Radefeldt, M., Santinelli, L., Griebner, N., Shambetova, C., Brand, M., Gabbert, C., Blauwendraat, C., Trinh, J., Beetz, C., Bauer, P., Brueggemann, N., Global Parkinson's Genetics Program (GP2), , Klein, C.

10.1101/2025.06.03.25328628 — Posted: 2025-06-03

Genetically Encoded and Modular SubCellular Organelle Probes (GEM-SCOPe) reveal lysosomal and mitochondrial dysfunction driven by PRKN knockout

Goldman, C., Kareva, T., Sarrafha, L., Sahasrabudhe, A., Schuldt, B. R., Ahfeldt, T., Blanchard, J. W.

10.1101/2024.05.21.594886 — Posted: 2025-06-02

Kase, D., Zimnik, A. J., Han, Y., Harsch, D. R., Bacha, S., Cox, K. M., Bostan, A. C., Richardson, R. M., Turner, R. S.

10.1101/2024.08.29.610310 — Posted: 2025-05-30

Sex-dimorphic effects of neuromelanin buildup in rodent nigral dopamine neurons: implications for sex-biased vulnerability in Parkinson's disease

D'Addario, S. L., Massaro Cenere, M., Cossa, F., Scaricamazza, S., Nesci, V., D'Ottavio, G., Caprioli, D., Ferri, A., Vila, M., Ledonne, A., Mercuri, N. B.

10.1101/2025.04.18.649338 — Posted: 2025-05-27

Genome-wide assessment identifies novel runs of homozygosity linked to Parkinson's disease etiology across diverse ancestral populations

Step, K., Hernandez, C. F., Eltaraifee, E., Hernandez-Medrano, A. J., Kung, P.-J., Ostrozovicova, M., Zirra, A., Perez-Palma, E., Mencacci, N. E., Keller Sarmiento, I. J., Morris, H., Mata, I., Global Parkinson's Genetics Program, , Acosta-Uribe, J., Fang, Z.-H., Bandres Ciga, S.

10.1101/2025.05.21.25328076 — Posted: 2025-05-22

Repetitive Levodopa Treatment Drives Cell Type-Specific Striatal Adaptations Associated With Progressive Dyskinesia in Parkinsonian Mice

Paz, R. M., Ryan, M. B., Marcott, P. F., Girasole, A. E., Faryean, J., Duong, V., Sridhar, S., Nelson, A. B.

10.1101/2025.05.16.654598 — Posted: 2025-05-21

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