Channel:  Human Pangenome Reference Consortium (HPRC)

158 Articles

Functional genomics reveals mediators of beta cell survival in ER stress and type 2 diabetes risk
Okino, M.-L., Zhu, H., Corban, S., Benaglio, P., Djulamsah, J., OMahony, B., Vanderstel, K., Elgamal, R., Miller, M., Wang, A., Sander, M., Gaulton, K. J.
10.64898/2026.03.30.715154 — Posted: 2026-04-02
pertTF: context-aware AI modeling for genome-scale and cross-system perturbation prediction
Su, Y., Liu, D., Menon, V., Song, B., Boccara, S., Zhang, N., Zhao, H., Zhao, J. H., Wang, L., Hu, N., Nzima, M., Katz, A., Swargam, B. K., Ament, S. A., Diao, Y., Zhang, H., Chao, L., Hon, G., Huangfu, D., Li, W.
10.64898/2026.03.12.711379 — Posted: 2026-03-16
Reprogramming of neuronal genome function and phenotype by astrocytes
Li, B., Hagy, K., Safi, A., Beer, M. A., Barrera, A., Geraghty, S., Rai, R., Pederson, A. N., Reisman, S. J., Love, M. I., Sullivan, P. F., Eroglu, C., Crawford, G. E., Gersbach, C. A.
10.64898/2026.03.07.710282 — Posted: 2026-03-07
FourC: identifying significant and differential contacts in 1D chromatin conformation data
Wong, W., Kaplan, S. J., Luo, R., Pulecio Rojas, J. A., Yan, J., Huangfu, D., Leslie, C. S.
10.64898/2026.03.05.709811 — Posted: 2026-03-07
Uncertainty-aware synthetic lethality prediction with pretrained foundation models
Hua, K., Haber, E., Ma, J.
10.64898/2026.02.25.708096 — Posted: 2026-02-27
A scalable approach to resolving variants of uncertain significance
Tejura, M., Chen, Y., McEwen, A. E., Stewart, R., Sverchkov, Y., Laval, F., Woo, I., Zeiberg, D., Shen, R., Fayer, S., Stone, J., Smith, N., Casadei, S., Wang, Z. R., Snyder, M., Capodanno, B. J., Gupta, P., Benazouz, M., Jain, S., Heidl, S., Muffley, L., Dong, S., Lin, K., Hitz, B. C., Gabdank, I., Da, E. Y., Best, S., Grindstaff, S., Reinhart, D., Rodriguez-Salas, L., Seid, O., Vandi, A. J., Wenman, C., Wheelock, M. K., Pendyala, S., Holmes, D., Xu, A., Hosokai, A., Tixhon, M., Reno, C., Ewald, J. D., Spirohn-Fitzgerald, K., Teelucksingh, T., Hao, T., Chen, Z. S., Haghighi, M., Hamid, A. K.
10.64898/2026.02.14.705848 — Posted: 2026-02-23
Fully T2T pedigree assemblies reveal genetic stability and epigenetic plasticity of human centromeres across inheritance and cell-fate transitions
Dong, S., Xing, X., Cechova, M., Loucks, H., Vijayalingam, S., Neilson, A., Sentmanat, M., Macias-Velasco, J. F., Liu, T., Dong, Z., Miao, B., Zhang, W., Tomlinson, C., Schmidt, H., Belter, E. A., Hu, M., Cui, X., Stitziel, N. O., Miga, K. H., Wang, T.
10.64898/2026.02.14.705860 — Posted: 2026-02-17
MissenseHMM: state-based annotations for missense variants through joint modeling of pathogenicity scores
Li, R., Ernst, J.
10.64898/2026.01.31.703062 — Posted: 2026-02-03
Spatial mapping of RNA turnover kinetics and regulatory landscapes of mRNA stability in the mammalian brain
Qiu, Q., Zhang, H., Xia, Z., Gao, W., Leu, J., Liang, D., Li, Y., Su, Y., Feierman, E., Horn, E. V., Ming, G.-l., Korb, E., Song, H., Zhou, Z., Wu, H.
10.64898/2026.01.29.702431 — Posted: 2026-01-29
FastGxC: Fast and Powerful Context-Specific eQTL Mapping in Bulk and Single-Cell Data
Krockenberger, L., Lu, A., Thompson, M., Liu, C., Gordon, M. G., Ramste, A., Carcamo-Orive, I., Knowles, J. W., Dahl, A., Ye, C. J., Zaitlen, N., Balliu, B.
10.1101/2021.06.17.448889 — Posted: 2025-12-11

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