Channel:  Aligning Science Across Parkinson's (ASAP)

403 Articles

Lysosomal Glucocerebrosidase is needed for ciliary Hedgehog signaling: A convergent pathway to Parkinsons disease
Nair, S. V., Jaimon, E., Adhikari, A., Nikoloff, J., Pfeffer, S. R.
10.1101/2025.01.20.633968 — Posted: 2025-01-21
Distinct spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian associations
Bouabid, S., Zhang, L., Vu, M.-A. T., Tang, K., Graham, B. M., Noggle, C. A., Howe, M. W.
10.1101/2024.07.10.602947 — Posted: 2025-01-21
Large-scale genetic characterization of Parkinson's disease in the African and African admixed populations
Akcimen, F., Paquette, K., Crea, P. W., Saffie-Awad, P., Achoru, C., Taiwo, F., Ozomma, S., Onwuegbuzie, G., Khani, M., Grant, S., Owolabi, L., Okereke, C., Oshinaike, O., Iwuozo, E., Lee, P. S., Oyakhire, S., Osemwegie, N., Daida, K., Abubakar, S., Olusanya, A., Isayan, M., Traurig, R., Ogunmodede, A., Samuel, S., Makarious, M. B., Saad, F., Olanigan, R., Levine, K., Ogbimi, E. M., Vitale, D., Odiase, F., Koretsky, M. J., Ojini, F., Odeniyi, O., Fang, Z.-H., Obianozie, N., Hall, D. A., Nwazor, E., Xie, T., Nwaokorie, F., Padmanaban, M., Nwani, P., Shamim, E. A., Nnama, A., Standaert, D., Komo
10.1101/2025.01.14.25320205 — Posted: 2025-01-20
LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development
Adami, A., Garza, R., Gerdes, P., Johansson, P. A., Dorazehi, F., Koutounidou, S., Castilla-Vallmanya, L., Atacho, D. A. M., Sharma, Y., Johansson, J. G., Tam, O., Kirkeby, A., Barker, R. A., Gale Hammell, M., Douse, C. H., Jakobsson, J.
10.1101/2025.01.17.633315 — Posted: 2025-01-17
Experimental and Computational Methods for Allelic Imbalance Analysis from Single-Nucleus RNA-seq Data
Simmons, S. K., Adiconis, X., Haywood, N., Parker, J., Lin, Z., Liao, Z., Tuncali, I., Al'Khafaji, A., Shin, A., Jagadeesh, K., Gosik, K., Gatzen, M., Smith, J. T., El Kodsi, D. N., Kuras, Y., Baecher-Allan, C., Serrano, G. E., Beach, T. G., Garimella, K., Rozenblatt-Rosen, O., Regev, A., Dong, X., Scherzer, C., Levin, J. Z.
10.1101/2024.08.13.607784 — Posted: 2025-01-15
Alpha-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation
Sitron, C. S., Trinkaus, V. A., Galesic, A., Garhammer, M., Yuste Checa, P., Dransfeld, U., Feigenbutz, D., Zhang, J., Dudanova, I., Harper, J. W., Hartl, F. U.
10.1101/2025.01.13.632710 — Posted: 2025-01-15
Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease
Chou, C.-C., Vest, R., Prado, M. A., Wilson-Grady, J., Paulo, J. A., Shibuya, Y., Moran-Losada, P., Lee, T.-T., Luo, J., Gygi, S. P., Kelly, J. W., Finley, D., Wernig, M., Wyss-Coray, T., Frydman, J.
10.1101/2023.03.27.534444 — Posted: 2025-01-13
Transgenic A53T mice have astrocytic α-synuclein aggregates in dopamine and striatal regions
Peat, C., Prasad, A., Finkelstein, D. I., Sue, C., Johnston, J., Parish, C., Thompson, L., Kirik, D., Halliday, G.
10.1101/2025.01.09.632283 — Posted: 2025-01-12
State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson's disease
Zhai, S., Cui, Q., Wokosin, D., Sun, L., Tkatch, T., Crittenden, J. R., Graybiel, A. M., Surmeier, D. J.
10.1101/2025.01.02.631090 — Posted: 2025-01-07
GPNMB is a biomarker for lysosomal dysfunction and is secreted via LRRK2-modulated lysosomal exocytosis
Bogacki, E. C., Longmore, G., Lewis, P. A., Herbst, S.
10.1101/2025.01.01.630988 — Posted: 2025-01-01

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