Channel:  Aligning Science Across Parkinson's (ASAP)

513 Articles

Multi-omics reveal critical differentiation target for Parkinsons' Disease-vulnerable midbrain dopaminergic neurons
Garcia Swinburn, R., Lyu, G., Kreutzmann, J. C., Xiong, A., Kojima, R., Abaurre, C., Tremolanti, C., Gellhaar, S., Uhlen, P., Svenningsson, P., Castelo Branco, G., Dagliyan, O., Salto, C., Arenas, E.
10.1101/2025.06.18.660098 — Posted: 2026-01-20
Cathepsin-dependent amyloid formation drives mechanical rupture of lysosomal membranes
Li, D., Zhang, W., Medina, M., Stuke, J. F. M., Schwarz, A., Brill, J., Brenner, J., Kraus, F., Ohlerich, S., Lizarrondo, J., Pflaum, J., Grass, J. H., Soltow, L.-M., Hammerschmid, D., Weber, N., Welsch, S., Langer, J., Windbergs, M., Harper, W. J., Schuman, E., Hummer, G., Grotjahn, D. A., Wilfling, F.
10.64898/2026.01.17.700056 — Posted: 2026-01-19
In vivo Proximity & Spatial Proteomics with CRISPR Screening Identify STXBP1 as a Protective Modifier of a-synuclein Toxicity in Dopamine Neurons.
Shonai, D., Kent, J., Okafor, A., Gao, Y., Parameswaran, P., Bustamante, E., Ramani, B., Diao, Y., Kampmann, M., Soderblom, E. J., Soderling, S. H.
10.64898/2026.01.16.699530 — Posted: 2026-01-17
Genome-Wide Association and Population-Tailored Polygenic Risk for Parkinson's Disease in Taiwan
Chu, Y.-T., Su, Y.-A., Lin, C.-H., Tai, C.-H., Wu, Y.-R., Hong, C.-T., Chen, Y.-W., Tsai, M.-H., Hardy, J., Wu, R.-M. R., Mok, K.-Y., East Asian Parkinson Disease Genomics Consortium, , Global Parkinson's Genetics Program
10.64898/2026.01.14.26344088 — Posted: 2026-01-16
The Global Landscape of Genetic Variation in Parkinson's disease: Multi-Ancestry Insights into Established Disease Genes and their Translational Relevance
Lange, L. M., Fang, Z.-H., Makarious, M. B., Kuznetsov, N., Atterling Brolin, K., Ballard, S., Bardien, S., Doquenia, M. L., Heutink, P., Houlden, H., Iwaki, H., Jasaityte, S., Jones, L., Junker, J., Kaiyrzhanov, R., Koretsky, M., Kumar, K. R., the Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD), , Leonard, H., Levine, K., Lim, S.-Y., Mencacci, N. E., Mohamed, W. M. Y., Nalls, M. A., Noyce, A., Ojha, R., Okubadejo, N. U., Rehman, S. u., Screven, L., Shashkin, C., Sopromadze, S., Stafford, E. J., Tan, A. H., Tan, M., Tavadyan, Z., Trinh, J., Tserensodnom, B
10.1101/2025.07.08.25330815 — Posted: 2026-01-14
Myeloid PINK1 represses mtDNA release and immune signaling that impacts neuronal pathology in patient-derived idiopathic PD models
Recinto, S. J., MacDonald, A., Premachandran, S., Liu, L., Bayati, A., Rodriguez, L., Nguyen, M., Petit, F., Mukherjee, S., Larmanjat, J., Allot, A., Yaqubi, M., McPherson, P. S., Durcan, T. M., Gruenheid, S., Trudeau, L.-E., Drouin-Ouellet, J., McBride, H. M., Stratton, J. A.
10.64898/2026.01.07.694713 — Posted: 2026-01-08
Shared and Sex-Specific Genetic Risk for Parkinson's Disease Risk Across European Populations
The Global Parkinson's Genetics Program (GP2), , Leonard, H. L.
10.64898/2025.12.29.25343160 — Posted: 2026-01-02
Postsynaptic adaptations in direct pathway muscarinic M4-receptor signaling follow the temporal and regional pattern of dopaminergic degeneration
Nielsen, B., Ford, C.
10.1101/2025.03.03.641233 — Posted: 2025-3-10
Variants in DNAJC13 Are Not Associated with Parkinson's Disease Across Different Ancestral Backgrounds
Avila, C. L., Isayan, M., Mecheri, Y., Saffie Awad, P., Leila, M. M., Screven, L. A., Leonard, H. L., Perinan, M. T., Levine, K., Makarious, M. B., Global Parkinson's Genetics Program (GP2)
10.64898/2025.12.30.25343211 — Posted: 2025-12-31
The Global Parkinson's Disease Genetics (GP2) Genome Browser
Fang, Z.-H., Grant, R. H., Vitale, D., Hernandez, C. F., Hong, S., Leonard, H. L., Makarious, M. B., Lange, L. M., Solomonson, M., Heutink, P., Dilliott, A. A., Galvelis, K. G., Nalls, M. A., Singleton, A. B., Blauwendraat, C., Global Parkinson's Genetics Program (GP2)
10.64898/2025.12.29.25343143 — Posted: 2025-12-31

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