Channel:  Aligning Science Across Parkinson's (ASAP)

451 Articles

GPNMB is a biomarker for lysosomal dysfunction and is secreted via LRRK2-modulated lysosomal exocytosis
Bogacki, E. C., Longmore, G., Lewis, P. A., Herbst, S.
10.1101/2025.01.01.630988 — Posted: 2025-01-01
A single Citrobacter rodentium infection in Pink1 knockout and wild type mice leads to regional blood-brain-barrier perturbation and glial activation without dopamine neuron axon terminal loss
Mukherjee, S., Grouza, V., Tchung, A., Even, A., Yaqubi, M., Tuznik, M., Cannon, T., Recinto, S. J., Gavino, C., Bourque, M.-J., McBride, H. M., Desjardins, M., Gruenheid, S., Stratton, J. A., Rudko, D. A., Trudeau, L.-E.
10.1101/2024.12.24.630165 — Posted: 2024-12-24
Neuronal alpha-Synuclein Disease stage progression over five years
Simuni, T., Gochanour, C., Nair, A. R., Brumm, M. C., Coffey, C., Poston, K. L., Chahine, L. M., Weintraub, D., Tanner, C. M., Gonzalez-Latapi, P., Kopil, C. M., Xiao, Y., Chowdhury, S., Dam, T., Pagano, G., Stephenson, D., Siderowf, A., Dunn, B., Marek, K., on behalf of the Parkinsons Progression Markers Initiative
10.1101/2024.12.17.24319172 — Posted: 2024-12-23
Anxa1+ dopamine neuron vulnerability defines prodromal Parkinson's disease bradykinesia and procedural motor learning impairment
Mantas, I., Contestabile, A., Skara, V., Loiseau, C., Santos, I., Cramb, K., Filograna, R., Wade-Martins, R., Magill, P., Meletis, K.
10.1101/2024.12.22.629963 — Posted: 2024-12-22
Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson's disease
Gaertner, Z., Oram, C., Schneeweis, A., Schonfeld, E., Bolduc, C., Chen, C., Dombeck, D. A., Parisiadou, L., Poulin, J. F., Awatramani, R.
10.1101/2024.06.06.597807 — Posted: 2024-12-22
The gut microbiome promotes mitochondrial respiration in the brain of a Parkinson's disease mouse model
Morais, L. H., Stiles, L., Freeman, M., Oguienko, A. D., Hoang, J. D., Jones, J., Quan, B., Devine, J., Bois, J. S., Chou, T.-F., Trinh, J., Picard, M., Gradinaru, V., Mazmanian, S. K.
10.1101/2024.12.18.629251 — Posted: 2024-12-21
A Vulnerable Subtype of Dopaminergic Neurons Drives Early Motor Deficits in Parkinson's Disease
Fushiki, A., Ng, D., Lewis, Z. R., Yadav, A., Saraiva, T., Hammand, L. A., Wirblich, C., Tasic, B., Menon, V., Silva, J. A. d., Costa, R. M.
10.1101/2024.12.20.629776 — Posted: 2024-12-21
Parkinson's Disease Pathogenic Variants: Cross-Ancestry Analysis and Microarray Data Validation
Hong, S., Koretsky, M. J., Lichtenberge, J., Leonard, H., Pitz, V., Global Parkinson's Genetics Program (GP2)
10.1101/2024.12.16.24319097 — Posted: 2024-12-17
The pyrethroid insecticide deltamethrin disrupts neuropeptide and monoamine signaling pathways in the gastrointestinal tract
White, A. C., Krout, I. N., Mouhi, S., Chang, J., Kelly, S. D., Caudle, W. M., Sampson, T.
10.1101/2024.12.14.628386 — Posted: 2024-12-17
Severe GBA1 variants drive the GBA-PD clinical phenotype: implications for counselling and clinical trials
Menozzi, E., Lucas Del Pozo, S., Macnaughtan, J., Mezabrovschi, R., Koletsi, S., Mitrotti, P., Gallo, L., Calabrese, R., Toffoli, M., Loefflad, N., Valzania, F., Cavallieri, F., Fioravanti, V., Yalkic, S., Limbachiya, N., Blandini, F., Avenali, M., Schapira, A. H.
10.1101/2024.12.09.24318560 — Posted: 2024-12-16

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