Channel:  Harvard Program in Therapeutic Sciences

126 Articles

UnMICST: Deep learning with real augmentation for robust segmentation of highly multiplexed images of human tissues
Yapp, C., Novikov, E., Jang, W.-D., Vallius, T., Chen, Y.-A., Cicconet, M., Maliga, Z., Jacobson, C. A., Wei, D., Santagata, S., Pfister, H., Sorger, P. K.
10.1101/2021.04.02.438285 — Posted: 2022-02-25
Fides: Reliable Trust-Region Optimization for Parameter Estimation of Ordinary Differential Equation Models
Froehlich, F., Sorger, P. K.
10.1101/2021.05.20.445065 — Posted: 2022-02-22
Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance
Froehlich, F., Gerosa, L., Muhlich, J. L., Sorger, P. K.
10.1101/2022.02.17.480899 — Posted: 2022-02-18
The spatial landscape of progression and immunoediting in primary melanoma at single cell resolution
Nirmal, A. J., Maliga, Z., Vallius, T., Quattrochi, B., Chen, A. A., Jacobson, C. A., Pelletier, R. J., Yapp, C., Arias-Camison, R., Chen, Y.-A., Lian, C. G., Murphy, G. F., Santagata, S., Sorger, P. K.
10.1101/2021.05.23.445310 — Posted: 2022-02-14
Single Cell Spatial Analysis Reveals the Topology of Immunomodulatory Purinergic Signaling in Glioblastoma
Coy, S., Wang, S., Stopka, S. A., Lin, J.-R., Rashid, R., Yapp, C., Ritch, C. C., Khadka, P., Regan, M., Hwang, J., Wen, P. Y., Bandopadhayay, P., Ligon, K. L., Agar, N. Y., Sorger, P. K., Touat, M., Santagata, S.
10.1101/2022.01.12.475925 — Posted: 2022-01-12
Characterization of metabolic compartmentalization in the liver using spatially resolved metabolomics
van der Reest, J., Stopka, S. A., Abdelmoula, W. M., Ruiz, D. F., Joshi, S., Ringel, A., Haigis, M. C., Agar, N. Y. R.
10.1101/2021.12.13.472421 — Posted: 2021-12-13
Design principles to assemble drug combinations for effective tuberculosis therapy using interpretable pairwise drug response measurements
Larkins-Ford, J., Degefu, Y. N., Van, N., Sokolov, A., Aldridge, B. B.
10.1101/2021.12.05.471248 — Posted: 2021-12-06
Gilda: biomedical entity text normalization with machine-learned disambiguation as a service
Gyori, B. M., Hoyt, C. T., Steppi, A.
10.1101/2021.09.10.459803 — Posted: 2021-09-11
STonKGs: A Sophisticated Transformer Trained on Biomedical Text and Knowledge Graphs
Balabin, H., Hoyt, C. T., Birkenbihl, C., Gyori, B. M., Bachman, J. A., Tom Kodamullil, A., Ploeger, P. G., Hofmann-Apitius, M., Domingo-Fernandez, D.
10.1101/2021.08.17.456616 — Posted: 2021-08-18
Integrating multi-omics data reveals function and therapeutic potential of deubiquitinating enzymes
Doherty, L. M., Mills, C. E., Boswell, S. A., Liu, X., Hoyt, C. T., Gyori, B. M., Buhrlage, S. J., Sorger, P. K.
10.1101/2021.08.06.455458 — Posted: 2021-08-09

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