Channel:  Harvard Program in Therapeutic Sciences

119 Articles

Combined inhibition of mTOR and PIKKs exploits replicative and checkpoint vulnerabilities to induce death of PI3K-activated triple-negative breast cancer cells
Chopra, S. S., Jenney, A., Palmer, A., Niepel, M., Chung, M., Mills, C., Sivakumaren, S. C., Liu, Q., Chen, J.-Y., Yapp, C., Asara, J., Gray, N. S., Sorger, P. K.
10.1101/700625 — Posted: 2019-07-12
A curative combination therapy for lymphomas achieves high fractional cell killing through low cross-resistance and drug additivity but not synergy
Palmer, A. C., Chidley, C., Sorger, P. K.
10.1101/462184 — Posted: 2019-07-12
Crosstalk and Ultrasensitivity in Protein Degradation Pathways
Mallela, A., Nariya, M. K., Deeds, E. J.
10.1101/594085 — Posted: 2019-03-30
Multi-omics profiling establishes the polypharmacology of FDA Approved CDK4/6 inhibitors and the potential for differential clinical activity
Hafner, M., Mills, C. E., Subramanian, K., Chen, C., Chung, M., Boswell, S. A., Everley, R. A., Liu, C., Walmsley, C. S., Juric, D., Sorger, P.
10.1101/211680 — Posted: 2019-03-19
Adaptation of human iPSC-derived cardiomyocytes to tyrosine kinase inhibitors reduces acute cardiotoxicity via metabolic reprogramming
Wang, H., Sheehan, R. P., Palmer, A. C., Everley, R. A., Boswell, S. A., Ron-Harel, N., Ringel, A. E., Holton, K. M., Jacobson, C. A., Erickson, A. R., Maliszewski, L., Haigis, M. C., Sorger, P. K.
10.1101/365841 — Posted: 2019-03-12
A multi-center study on factors influencing the reproducibility of in vitro drug-response studies
Niepel, M., Hafner, M., Mills, C., Subramanian, K., Williams, E. H., Chung, M., Gaudio, B., Barrette, A. M., Stern, A. D., Hu, B., Korkola, J. E., LINCS Consortium, , Gray, J. W., Birtwistle, M. R., Heiser, L. M., Sorger, P. K.
10.1101/213553 — Posted: 2019-02-05
Re-curation and Rational Enrichment of Knowledge Graphs in Biological Expression Language
Hoyt, C., Domingo-Fernandez, D., Aldisi, R., Xu, L., Kolpeja, K., Spalek, S., Wollert, E., Bachman, J., Gyori, B., Greene, P., Hofmann-Apitius, M.
10.1101/536409 — Posted: 2019-01-31
Highly multiplexed in situ protein imaging with signal amplification by Immuno-SABER
Saka, S. K., Wang, Y., Kishi, J. Y., Zhu, A., Zeng, Y., Xie, W., Kirli, K., Yapp, C., Cicconet, M., Beliveau, B. J., Lapan, S. W., Yin, S., Lin, M., Boyden, E. S., Kaeser, P. S., Pihan, G., Church, G. M., Yin, P.
10.1101/507566 — Posted: 2018-12-28
End-to-end differentiable learning of protein structure
AlQuraishi, M.
10.1101/265231 — Posted: 2018-08-29
pNeRF: Parallelized Conversion from Internal to Cartesian Coordinates
AlQuraishi, M.
10.1101/385450 — Posted: 2018-08-06

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